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dexamethasone 21-methanesulfonate
RN given refers to (11beta,16alpha)-isomer
Also Known As:
dexamethasone 21-mesylate
Networked:
10
relevant articles (
0
outcomes,
1
trials/studies)
Bio-Agent Context: Research Results
Polycyclic Compounds: 6
Fused-Ring Compounds
Steroids: 70059
Fluorinated Steroids: 32
Dexamethasone: 23151
dexamethasone 21-methanesulfonate: 10
Pregnanes: 9
Pregnadienes
Pregnadienetriols
Dexamethasone: 23151
dexamethasone 21-methanesulfonate: 10
Experts
1.
Kurihara, Takashi
: 1 article (11/2005)
2.
Saegusa, Hironao
: 1 article (11/2005)
3.
Takasaki, Ichiro
: 1 article (11/2005)
4.
Tanabe, Tsutomu
: 1 article (11/2005)
5.
Zong, Shuqin
: 1 article (11/2005)
Related Diseases
1.
Hepatocellular Carcinoma (Hepatoma)
06/01/1992 - "
Previous studies have documented that the amount of agonist activity expressed by the antiglucocorticoid dexamethasone 21-mesylate (Dex-Mes) for tyrosine aminotransferase (TAT) induction in two rat hepatoma cell lines (Fu5-5 and HTC) is greater in Fu5-5 cells and could be varied in each cell line with changes in cell density.
"
03/01/1992 - "
For example, in tyrosine aminotransferase (TAT) induction by the antiglucocorticoid dexamethasone 21-mesylate in rat hepatoma tissue culture cells, the percent agonist activity varies with the density of cultured cells.
"
07/01/1988 - "
Inverse correlation between dexamethasone 21-mesylate agonist activity and sensitivity to dexamethasone for induction of tyrosine aminotransferase in rat hepatoma cells.
"
07/15/1987 - "
Selective covalent labeling of cysteines in bovine serum albumin and in hepatoma tissue culture cell glucocorticoid receptors by dexamethasone 21-mesylate.
"
07/15/1987 - "
Recent results using proteases suggest that dexamethasone 21-mesylate (Dex-Mes) labeling of the rat hepatoma tissue culture (HTC) cell glucocorticoid receptor occurs at one or a few closely grouped cysteine residues (Simons, S.S., Jr.
"
2.
Thymoma (Thymic Carcinoma)
05/17/1988 - "
Nonactivated glucocorticoid receptors obtained from labeling intact WEHI-7 mouse thymoma cells with [3H]dexamethasone 21-mesylate were immunopurified and analyzed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis.
"
04/25/1987 - "
In order to determine the ratio of phosphates to hormone-binding sites on nonactivated (non-DNA-binding) glucocorticoid receptors in WEHI-7 mouse thymoma cells, we have extracted these receptors from cells grown to a steady state with 32P, labeled them with a saturating concentration of [3H]dexamethasone 21-mesylate, purified them using a monoclonal antibody, and analyzed them by polyacrylamide gel electrophoresis under denaturing and reducing conditions.
"
3.
Lymphoma (Lymphomas)
01/01/1987 - "
Characterization of glucocorticoid receptors in S49 mouse lymphoma cells by affinity labeling with [3H]dexamethasone 21-mesylate.
"
01/01/1987 - "
Glucocorticoid receptors in wild type and mutant S49 mouse lymphoma cells were affinity labeled with [3H]dexamethasone 21-mesylate and analyzed directly by sodium dodecyl sulfate-polyacrylamide gel electrophoresis.
"
10/01/1993 - "
Characterization of the antibody with intracellular GR (iGR) showed its ability to shift [3H]triamcinolone acetonide-labeled GR (4S protein) from two human leukemic cell lines to a higher density in sucrose gradients; Western and autoradiographic analysis of affinity-labeled ([3H]dexamethasone 21-mesylate) receptor revealed an immunoreactive and competitively labeled band of 94 kDa. CCRF-CEM cell membrane GR (mGR) resolved as a > 7S protein on density gradients and immunoselected cell surface protein labeled by whole cell biotinylation or affinity-labeling with [3H]dexamethasone 21-mesylate was approximately 145 kDa, demonstrating that mGR was larger in size than iGR, as has been shown previously for the mGR of mouse lymphoma cells.
"
4.
Hyperalgesia
11/07/2005 - "
The more selective antagonist dexamethasone 21-mesylate suppressed both mechanical allodynia and thermal hyperalgesia.
"
Related Drugs and Biologics
1.
Tyrosine Transaminase (Tyrosine Aminotransferase)
2.
Glucocorticoid Receptors (Glucocorticoid Receptor)
3.
polyacrylamide
4.
Sodium Dodecyl Sulfate (Sodium Lauryl Sulfate)
5.
Dexamethasone (Maxidex)
6.
Triamcinolone Acetonide (Azmacort)
7.
Sucrose (Saccharose)
8.
Bovine Serum Albumin
9.
Proteins (Proteins, Gene)
10.
Phosphates (Orthophosphate)