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hemoglobin G Philadelphia
Asn replaced by Lys in position 68 on alpha chain
Also Known As:
HBA2 g.324C>A; HBA2 g.324C>G; Hb G Phila; Hb G-Philadelphia; Hb alpha-G Philadelphia
Networked:
10
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Amino Acids, Peptides, and Proteins: 1
Proteins: 484843
Blood Proteins: 12459
Hemoglobins: 37188
Abnormal Hemoglobins: 120
hemoglobin G Philadelphia: 10
Hemeproteins: 194
Globins: 2716
Hemoglobins: 37188
Abnormal Hemoglobins: 120
hemoglobin G Philadelphia: 10
Related Diseases
1.
beta-Thalassemia (Cooley's Anemia)
08/01/1982 - "
Organization of alpha-chain genes among Hb G-Philadelphia heterozygotes in association with Hb S, beta-thalassemia, and alpha-thalassemia-2.
"
08/01/1978 - "
The percentage of Hb G-Philadelphia was not influenced by the simultaneous presence of a beta-thalassemai determinant, but that of Hb Rampa was descreased from 20% in the simple heterozygote to about 6% in persons with the Hb Rampa-beta-thalassemia combination.
"
08/01/1978 - "
Two unrelated families are reported in which beta-thalassemia trait occurred with a heterozygosity of Hb G-Philadelphia (alpha2 68(E17)Asn leads to Lys beta2) in one family and with Hb Rampa (alpha2 95(G2)Pro leads to Ser beta2) in the other.
"
08/01/1978 - "
Variability in the interaction of beta-thalassemia with the alpha-chain variants Hb G-Philadelphia and Hb Rampa.
"
01/01/1981 - "
The subjects included normal adults (alpha alpha/alpha alpha) with or without a beta chain variant (Hb S, Hb Leslie) or an alpha chain variant (Hb G-Georgia); alpha-thalassemia-2 heterozygotes (alpha 0 alpha/alpha alpha) with an alpha chain variant (G-Georgia or G-Philadelphia); an alpha-thalassemia-1 heterozygote (alpha 0 alpha 0/alpha alpha); alpha-thalassemia-2 homozygotes (alpha 0 alpha 0/alpha 0 alpha) with a beta chain variant (Hb S), an alpha chain variant (G-Philadelphia), a Hb S homozygosity with Hb G-Philadelphia, or a Hb G-Philadelphia homozygosity; and three black beta +-thalassemia homozygotes.
"
2.
alpha-Thalassemia
06/01/1988 - "
[Association of alpha thalassemia and Hb G Philadelphia in a Spanish family].
"
01/01/1982 - "
Homozygous alpha thalassemia/Hb G Philadelphia.
"
01/01/1980 - "
alpha Thalassemia and the expression of hemoglobin G-Philadelphia.
"
3.
Sickle Cell Anemia (Hemoglobin S Disease)
02/01/1964 - "
SICKLE CELL ANEMIA WITH TWO ADULT HEMOGLOBINS--HB S AND HB G-PHILADELPHIA/S.
"
08/01/1993 - "
We have studied three sickle cell anemia patients who also carried a heterozygosity for one of the following alpha chain abnormalities: Hb G-Philadelphia [alpha 68(E17)Asn-->Lys], Hb Montgomery [alpha 48 (CE6)Leu-->Arg], and Hb Chicago [alpha 136(H19)Leu-->Met].
"
4.
Anemia
01/01/1982 - "
Microcytic red cells from a 70 year old Negro man with mild anemia contained only hemoglobin G-Philadelphia.
"
01/01/1980 - "
A 21-year-old American black female with mild anemia was found to be triply heterozygous for alpha-thalassemia-2, hemoglobin S and hemoglobin G Philadelphia.
"
5.
Ascites
01/01/1988 - "
The ascites fluid containing the Hb G-Philadelphia Mab was added to the wells followed by goat anti-mouse IgG conjugated with horseradish peroxidase.
"
Related Drugs and Biologics
1.
Immunoglobulin G (IgG)
2.
Horseradish Peroxidase
3.
Hemoglobins (Hemoglobin)
4.
Sickle Hemoglobin
5.
leucylarginine
6.
leucylmethionine
7.
hemoglobin Chicago
8.
hemoglobin G Georgia
9.
hemoglobin Shelby
10.
hemoglobin Montgomery