ursodoxicoltaurine

Also Known As:

TUDCA; chenyl taurine sodium; tauroursodeoxycholate; tauroursodeoxycholate sodium salt; tauroursodeoxycholic acid; tauroursodeoxycholic acid, (3alpha,5alpha,7alpha)-isomer; tauroursodeoxycholic acid, monosodium salt, (3alpha,5beta,7alpha)-isomer; taurursodiol

Networked: 431 relevant articles (69 outcomes, 85 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Acyclic Hydrocarbons
    - Alkanes: 241
      - Alkanesulfonic Acids
        Taurine: 3452
        Taurocholic Acid: 1216
        Taurodeoxycholic Acid: 87
        Taurochenodeoxycholic Acid: 76
        ursodoxicoltaurine: 431
- Sulfur Compounds: 278
  - Sulfur Acids
    - Sulfonic Acids: 1605
      - Alkanesulfonic Acids
        Taurine: 3452
        Taurocholic Acid: 1216
        Taurodeoxycholic Acid: 87
        Taurochenodeoxycholic Acid: 76
        ursodoxicoltaurine: 431
Polycyclic Compounds: 6
- Fused-Ring Compounds
  - Steroids: 70059
    - Bile Acids and Salts: 11432
      - Cholic Acids: 14
        Taurocholic Acid: 1216
        Taurodeoxycholic Acid: 87
        Taurochenodeoxycholic Acid: 76
        ursodoxicoltaurine: 431
        Deoxycholic Acid: 963
        Chenodeoxycholic Acid: 877
        Taurochenodeoxycholic Acid: 76
        ursodoxicoltaurine: 431
        Taurodeoxycholic Acid: 87
        Taurochenodeoxycholic Acid: 76
        ursodoxicoltaurine: 431
    - Cholanes
      - Cholic Acids: 14
        Taurocholic Acid: 1216
        Taurodeoxycholic Acid: 87
        Taurochenodeoxycholic Acid: 76
        ursodoxicoltaurine: 431
        Deoxycholic Acid: 963
        Chenodeoxycholic Acid: 877
        Taurochenodeoxycholic Acid: 76
        ursodoxicoltaurine: 431
        Taurodeoxycholic Acid: 87
        Taurochenodeoxycholic Acid: 76
        ursodoxicoltaurine: 431

Experts

1.	Steer, Clifford J: 13 articles (05/2014 - 01/2002)
2.	Rodrigues, Cecília M P: 9 articles (05/2018 - 11/2004)
3.	Rodrigues, Cecilia M P: 7 articles (01/2016 - 01/2002)
4.	Low, Walter C: 7 articles (05/2014 - 01/2002)
5.	Boatright, Jeffrey H: 6 articles (03/2022 - 12/2006)
6.	Castro-Caldas, Margarida: 6 articles (01/2019 - 01/2017)
7.	Gama, Maria João: 6 articles (01/2019 - 01/2017)
8.	Nunes, Maria João: 6 articles (01/2019 - 01/2017)
9.	Rodrigues, Elsa: 6 articles (01/2019 - 01/2017)
10.	Lee, Jun Hee: 5 articles (01/2019 - 03/2015)

Related Diseases

1.	Cholestasis 05/01/2001 - "Tauroursodeoxycholate is reported to be effective in CyA-induced cholestasis in rats. " 01/01/1992 - "Drug-induced cholestasis in the perfused rat liver and its reversal by tauroursodeoxycholate: an ultrastructural study." 01/01/2023 - "Moreover, inhibiting CHOP-DR5-caspase-8 pathway contributed to the anti-apoptotic effect of TUDCA in cholestasis." 01/01/2023 - "Until now, TUDCA's mechanism of action toward cholestasis remains unclear. " 12/01/2017 - "Tauroursodeoxycholate (TUDC) and cAMP reverse TLC-induced cholestasis by inhibiting TLC-induced retrieval of MRP2. "
2.	Insulin Resistance 01/01/2015 - "However, the mechanism underlying how TUDCA is involved in insulin resistance is not fully understood. " 08/01/2010 - "These data demonstrate that TUDCA might be an effective pharmacological approach for treating insulin resistance. " 08/01/2010 - "Tauroursodeoxycholic Acid may improve liver and muscle but not adipose tissue insulin sensitivity in obese men and women." 01/01/2021 - "Intraperitoneal administration of TUDCA suppressed ER stress in the peripheral tissues and ameliorated the HFD-induced obesity and insulin resistance. " 01/01/2018 - "TUDCA administration attenuated HFD-induced hepatic steatosis, inflammatory responses, obesity and insulin resistance in mice. "
3.	Inflammation (Inflammations) 10/03/2022 - "The present study demonstrated that the TUDCA inhibits ocular inflammation and protects the cornea and retina from injury in an OAB mouse model. " 01/01/2022 - "A total of thirty-five pre-clinical studies were identified through PubMed/Medline, Web of Science, Embase, PsychInfo, and CINAHL databases, investigating the role of the UDCA, GUDCA and TUDCA in the regulation of brain apoptosis, oxidative stress and inflammation, in pre-clinical models of neurological, neurodegenerative and neuropsychiatric disorders. " 01/01/2022 - "Due to their beneficial actions, recent studies have started to investigate the effect of UDCA, GUDCA, TUDCA on the same mechanisms in pre-clinical models of neurological, neurodegenerative and neuropsychiatric disorders, where increased cell apoptosis, oxidative stress and inflammation in the brain are often observed. " 01/01/2023 - "An increase in inflammation and ER stress in retina coincided with an increase in TGR5 expression in diabetic tie2-TNF mice that decreased with TUDCA. " 11/01/2022 - "TUDCA also alleviated IR, and reduced oxidative stress and intestinal inflammation in ob/ob mice. "
4.	Retinal Degeneration 07/01/2011 - "Tauroursodeoxycholic acid prevents retinal degeneration in transgenic P23H rats." 12/29/2006 - "Systemic injection of TUDCA, a primary constituent of bear bile, profoundly suppressed apoptosis and preserved function and morphology of photoreceptor cells in two disparate mouse models of retinal degeneration. " 12/29/2006 - "By every measure, TUDCA greatly slowed retinal degeneration in LIRD and rd10 mice. " 01/01/2017 - "Controlled delivery of tauroursodeoxycholic acid from biodegradable microspheres slows retinal degeneration and vision loss in P23H rats." 09/21/2020 - "Our present study suggests that TUDCA can protect RPE cells against oxidative damage, inflammation, and ER stress and may benefit patients with retinal degeneration."
5.	Neurodegenerative Diseases (Neurodegenerative Disease) 01/01/2022 - "While further clinical evidence is being accumulated for the other diseases, TUDCA stands as a promising treatment for neurodegenerative diseases." 01/01/2022 - "Tauroursodeoxycholic acid: a potential therapeutic tool in neurodegenerative diseases." 10/01/2017 - "The demonstration that pharmacological up-regulation of mitophagy by TUDCA prevents neurodegeneration provides new insights for the use of TUDCA as a modulator of mitochondrial activity and turnover, with implications in neurodegenerative diseases." 11/20/2019 - "Thus, TUDCA has been demonstrated to display potential therapeutic benefits in various models of many diseases such as diabetes, obesity, and neurodegenerative diseases, mostly due to its cytoprotective effect. " 01/01/2016 - "In addition, TUDCA exhibits anti-inflammatory effects in models of neuroinflammation and attenuates neuronal loss in chronic neurodegenerative diseases. "

Related Drugs and Biologics

1.	ursodoxicoltaurine
2.	Bile Acids and Salts (Bile Acids)
3.	Glucose (Dextrose)
4.	Proteins (Proteins, Gene)
5.	Taurolithocholic Acid
6.	Ursodeoxycholic Acid (Urso)
7.	Taurine
8.	Tunicamycin
9.	Lipopolysaccharides
10.	Endoplasmic Reticulum Chaperone BiP

Related Therapies and Procedures

1.	Therapeutics
2.	Transplantation
3.	Injections
4.	Liver Transplantation
5.	Microspheres (Microsphere)