phenothiazine

12/01/2023 - "The compounds introduced in the current study work provided a cutting-edge phenothiazine hybrid scaffold with promising anti-proliferation action that may suggest their anti-cancer activity."
12/01/2023 - "A total of seventeen novel phenothiazine derivatives have been designed, synthesized, and evaluated primarily in-vitro for their ability to inhibit proliferation activity against NCI-60 cancer cell lines, including several multi-drug resistant (MDR) tumor cell lines. "
12/01/2023 - "New phenothiazine conjugates as apoptosis inducing agents: Design, synthesis, In-vitro anti-cancer screening and 131I-radiolabeling for in-vivo evaluation."
06/05/2023 - "The design and the synthetic strategies adopted, the SAR investigations and the role of reviewed phenothiazine derivatives as anti-cancer agents and multi-drug resistance (MDR) reversals are here fully described and discussed."
01/01/2020 - "A series of novel 1,3-thiazole derivatives (5a-i) with a modified phenothiazine moiety were synthesized and tested against cancer cell line MCF-7 for their cytotoxicity. "

01/01/2023 - "In this study, we screened several US FDA-approved drugs and identified phenothiazine derivatives with the ability to potently inhibit the infection of pseudotyped SARS-CoV-2 and distinct variants of concern (VOCs), including B.1.617.2 (Delta) and currently circulating Omicron sublineages XBB and BQ.1.1, as well as pseudotyped SARS-CoV and MERS-CoV. "
11/01/2021 - "The present study indicates that repurposing phenothiazine derivatives for treating recalcitrant infections by A. "
12/01/1952 - " XIX. Further studies in the use of small amounts of phenothiazine in pure infections of the nodular worm."
12/01/1950 - "Studies on bovine gastrointestinal parasites XVI. Some results of feeding small amounts of phenothiazine on pure infections of the hookworm Bunostomum phlebotomum."
01/01/2019 - "Molecules of the diphenylpiperazine, diphenylpiperidine, phenothiazine, thioxanthene, and cycloheptenepiperidine chemotypes inhibit HCV infection by interfering with membrane fusion. "

01/01/1991 - "The selective accumulation of phenothiazine derivatives in certain tissues such as brain and melanoma tumors may provide an effective treatment of such tumors. "
11/01/1976 - "Four phenothiazine derivatives containing the bis(beta-chloroethyl)aminopropyl side chain were prepared and evaluated in the murine L-1210, P-388, and B-16 melanoma intraperitoneal tumor systems. "
11/15/2016 - "The most antineoplastic agent in the current study was phenothiazine 5 displaying a GI50 of 25nM against the melanoma MDA-MB-435 cell line."
09/01/1997 - "On colon cancer lines, tumor cells from the central nervous system and on melanoma cells the same compounds were effective, however, having substituents at the 2-position of phenothiazine seems to be important. "
08/01/1989 - "The investigations concerning a targeted radiotherapy for pigmented melanoma with a radiolabeled phenothiazine derivative, 3,7-(dimethylamino)phenazathionium chloride [methylene blue (MTB)], were continued using melanotic and amelanotic sublines of B16 melanoma. "

11/01/1993 - "Two years later Sigwald et al. reported involuntary movements of the tongue, lips and facial muscles which appeared after several years of phenothiazine treatment. "
05/01/1985 - "One of the patients experienced recurrence of the dyskinesia during a challenge with phenothiazine tranquilizers. "
03/01/1981 - "Phenothiazine induced dyskinesia in children."
05/01/1971 - "[Facial dyskinesias caused by phenothiazine derivatives]."
03/01/1970 - "Treatment of persistent phenothiazine-induced oral dyskinesia."

01/01/2018 - "Various chemical scaffolds are being investigated against tuberculosis, among them the molecules containing phenothiazine nucleus are found to be more effective against both susceptible and resistant strains of M. "
01/01/2018 - "Phenothiazine: A Better Scaffold against Tuberculosis."
03/01/2003 - "tuberculosis at concentrations in the medium that are clinically relevant, we have investigated whether TZ, a phenothiazine whose negative side effects are less frequent and serious than those associated with CPZ, kills M. "
03/13/1958 - "[Complications in tuberculosis treatment with phenothiazine derivatives]."
12/01/2014 - "Thioridazine, a potent phenothiazine compound was evaluated for its chemotherapeutic efficacy against experiment model of tuberculosis. "