|1.||Rubio-Martinez, Jaime: 1 article (04/2014)|
|2.||Díaz-Moralli, Santiago: 1 article (04/2014)|
|3.||Obiol-Pardo, Cristian: 1 article (04/2014)|
|4.||Cascante, Marta: 1 article (04/2014)|
|5.||Alcarraz-Vizán, Gema: 1 article (04/2014)|
|6.||Wu, Mian: 1 article (01/2014)|
|7.||Jiang, Peng: 1 article (01/2014)|
|8.||Du, Wenjing: 1 article (01/2014)|
|9.||Lloyd, Georgina S: 1 article (04/2011)|
|10.||Lovering, Andrew L: 1 article (04/2011)|
04/01/2014 - "Recently, G6PDH was suggested as a novel target protein for cancer therapy as one of the final products of the PPP, ribose-5-phosphate, is necessary for nucleic acid synthesis and tumor progression. "
11/01/1960 - "Formation of ketopentoses, beginning with ribose-5-phosphate, in the serum of patients with cancer."
01/01/2014 - "It has become clear that the PPP plays a critical role in regulating cancer cell growth by supplying cells with not only ribose-5-phosphate but also NADPH for detoxification of intracellular reactive oxygen species, reductive biosynthesis and ribose biogenesis. "
11/01/1991 - "To obtain insight into the recruitment of precursors for these cosubstrates, the authors also tested the enzyme activity of pyrimidine nucleoside phosphorylase with inosine and ribose-5-phosphate (Rib-5-P, as precursors for Rib-1-P) and deoxyinosine (as a precursor for dRib-1-P); enzyme activities were approximately 7%, 7%, and 3%, respectively, of that with the normal substrates, both in tumors and mucosa. "
11/01/1991 - "Further evidence of a reduced NADPH and ribose-5-phosphate pool on the lowering of intracellular deoxyribonucleotide levels has been demonstrated in this paper by completely reversing the 16 alpha-fluoro-5-androsten-17-one-induced inhibition of tumor promotion by the addition of the four deoxyribonucleosides-deoxyadenosine, deoxycytidine, deoxyguanosine and thymidine--to the drinking water during the promotion period of tumorigenesis."
|2.||Renal Insufficiency (Renal Failure)
01/01/1986 - "Storage of glutamyl ribose-5-phosphate was identified at autopsy in the brain and kidney of an 8-year-old male who had presented clinically with progressive renal failure and neurological deterioration. "
07/19/1984 - "Progressive neurologic deterioration and renal failure due to storage of glutamyl ribose-5-phosphate."
10/10/2008 - "tuberculosis enzyme, both co-crystallized with the substrate ribose-5-phosphate, shed additional light on the reaction mechanism of RpiBs generally."
04/01/2011 - "tuberculosis, a single pRpp synthetase enzyme (Mt-PrsA) is solely responsible for the generation of pRpp, by catalyzing the transfer of pyrophosphate from ATP to the C1 hydroxyl position of ribose-5-phosphate. "
|4.||beta-Thalassemia (Cooley's Anemia)
|1.||Ribose-Phosphate Pyrophosphokinase (Phosphoribosyl Pyrophosphate Synthetase)
|3.||Adenosine Triphosphate (ATP)
|6.||Glutamic Acid (Glutamate)
|8.||Reactive Oxygen Species (Oxygen Radicals)