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polyethylene glycol-uricase

uricase covalently attached to polyethylene glycol, modifying 71% of amino groups & retaining 11% of activity without eliciting antibody response in mice or man; used for lowering serum uric acid
Also Known As:
PEG-uricase; Pegloticase; Puricase; methoxypolyethylene glycol uricase
Networked: 62 relevant articles (14 outcomes, 19 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1. Sundy, John S: 11 articles (12/2014 - 01/2006)
2. Baraf, Herbert S B: 8 articles (12/2014 - 09/2008)
3. Becker, Michael A: 6 articles (12/2014 - 09/2008)
4. Yood, Robert A: 5 articles (12/2014 - 08/2011)
5. Ottery, Faith D: 4 articles (12/2014 - 01/2013)
6. Ganson, Nancy J: 4 articles (01/2014 - 01/2006)
7. Hershfield, Michael S: 4 articles (01/2014 - 01/2006)
8. Kelly, Susan J: 4 articles (01/2014 - 01/2006)
9. Edwards, N Lawrence: 4 articles (07/2012 - 08/2011)
10. Huang, William: 4 articles (08/2011 - 03/2007)

Related Diseases

1. Gout
2. Hyperuricemia
3. Pain (Aches)
4. Renal Insufficiency (Renal Failure)
5. Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)

Related Drugs and Biologics

1. Uric Acid (Urate)
2. Urate Oxidase (Uricase)
3. Polyethylene Glycols (Polyethylene Glycol)
4. febuxostat
5. Antibodies
6. monomethoxypolyethylene glycol (MPEG)
7. Venoms
8. pegaspargase (Oncaspar)
9. Interleukin-1 (Interleukin 1)
10. Ethylene Glycol (Monoethylene Glycol)

Related Therapies and Procedures

1. Transplants (Transplant)
2. Therapeutics
3. Subcutaneous Injections
4. Renal Dialysis (Hemodialysis)
5. Wheelchairs (Wheel Chair)