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chalepin

furanocoumarin isolated from West African medicinal plant Clausena anisata; RN given refers to cpd without isomeric designation

Also Known As:

chalepin, (+-)-isomer

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrans: 130
    - Benzopyrans: 195
      - Coumarins: 826
        Furocoumarins: 490
        chalepin: 4
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzopyrans: 195
      - Coumarins: 826
        Furocoumarins: 490
        chalepin: 4
  - 3-Ring Heterocyclic Compounds
    - Furocoumarins: 490
      - chalepin: 4

Experts

1.	Abd Malek, Sri Nurestri: 2 articles (03/2019 - 10/2017)
2.	Fakai, Musa Isah: 1 article (03/2019)
3.	Karsani, Saiful Anuar: 1 article (03/2019)
4.	Aminudin, Norhaniza: 1 article (10/2017)
5.	Richardson, Jaime Stella Moses: 1 article (10/2017)
6.	Castilho, Marcelo S: 1 article (05/2003)
7.	Lopes, Julio C D: 1 article (05/2003)
8.	Menezes, Irwin R A: 1 article (05/2003)
9.	Montanari, Carlos A: 1 article (05/2003)
10.	Oliva, Glaucius: 1 article (05/2003)

Related Diseases

1.	Chagas Disease (American Trypanosomiasis) 05/01/2003 - "The compound with the highest binding affinity was the coumarin chalepin, isolated from Rutaceae species, with an IC50 value of 55.5 microM towards the enzyme glyceraldehyde-3-phosphate dehydrogenase (gGAPDH) from glycosomes of the parasite Trypanosoma cruzi, the causative agent of Chagas' disease. "
2.	Neoplasms (Cancer) 03/01/2019 - "From our recent findings, chalepin was able to induced apoptosis in MCF7 cells and therefore, could be evaluated further as a potential source of anticancer agent for cancer treatment such as breast cancer."
3.	Necrosis 01/01/1981 - "Liver lesions were observed in chalepin treated animals and were characterized by very mild necrosis of hepatocytes. "
4.	Carcinoma (Carcinomatosis) 10/01/2017 - "A dihydrofuranocoumarin named chalepin, which was isolated from the chloroform extract of the plant, was tested on its ability to inhibit molecular pathways of human lung carcinoma (A549) cells. "
5.	Breast Neoplasms (Breast Cancer) 03/01/2019 - "Induction of apoptosis by chalepin through phosphatidylserine externalisations and DNA fragmentation in breast cancer cells (MCF7)." 03/01/2019 - "From our recent findings, chalepin was able to induced apoptosis in MCF7 cells and therefore, could be evaluated further as a potential source of anticancer agent for cancer treatment such as breast cancer."

Related Drugs and Biologics

1.	Phosphatidylserines
2.	Glyceraldehyde-3-Phosphate Dehydrogenases (GAPD)
3.	Enzymes
4.	Chloroform (Trichloromethane)
5.	Antineoplastic Agents (Antineoplastics)
6.	coumarin