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4-O-methylascochlorin

causes unusual concentration of urine & prevents polydipsia in DOCA hypertensive rats; structure given in first source

Networked: 4 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - 4-O-methylascochlorin: 4

Experts

1.	Chang, Young-Chae: 4 articles (10/2020 - 03/2011)
2.	Magae, Junji: 4 articles (10/2020 - 03/2011)
3.	Jeong, Yun-Jeong: 2 articles (10/2020 - 12/2019)
4.	Bae, Young-Seuk: 1 article (10/2020)
5.	Han, Si-Yoon: 1 article (10/2020)
6.	Hwang, Soon-Kyung: 1 article (10/2020)
7.	Furukawa, Chiharu: 1 article (12/2019)
8.	Kuwahara, Shigefumi: 1 article (12/2019)
9.	Nakajima, Hiroo: 1 article (12/2019)
10.	Ito, Akihiro: 1 article (01/2019)

Related Diseases

1.	Leukemia 10/01/2020 - "A prior study identified that 4-O-methylascochlorin (MAC), a methylated derivative of ascochlorin (ASC) from the fungus Ascochyta viciae, activates autophagy in leukemia cells by suppressing c-Myc phosphorylation. "
2.	Hypoxia (Hypoxemia) 01/01/2019 - "4-O-Methylascochlorin inhibits the prolyl hydroxylation of hypoxia-inducible factor-1α, which is attenuated by ascorbate." 03/18/2011 - "We also examined a regulatory mechanism for hypoxia-inducible factor-1α (HIF-1α) stabilization in response to 4-O-methylascochlorin (MAC). " 01/01/2019 - "4-O-Methylascochlorin (MAC), a methylated derivative of ascochlorin, was previously shown to promote the accumulation of hypoxia-inducible factor (HIF)-1α in human breast adenocarcinoma MCF-7 cells. " 12/01/2019 - "4-O-methylascochlorin stabilizes hypoxia-inducible factor-1 in a manner different from hydroxylase inhibition by iron chelating or substrate competition."
3.	Osteosarcoma (Osteogenic Sarcoma) 12/01/2019 - "Here, we quantified protein level of HIF-1α in human osteosarcoma U2OS cells treated with ascochlorin-related compounds and typical HIF-1α stabilizers to characterize properties of HIF-1α stabilization by 4-O-methylascochlorin. "
4.	Glioblastoma (Glioblastoma Multiforme) 10/01/2020 - "4-O-methylascochlorin activates autophagy by activating AMPK and suppressing c-Myc in glioblastoma."
5.	Adenocarcinoma 01/01/2019 - "4-O-Methylascochlorin (MAC), a methylated derivative of ascochlorin, was previously shown to promote the accumulation of hypoxia-inducible factor (HIF)-1α in human breast adenocarcinoma MCF-7 cells. "

Related Drugs and Biologics

1.	ascochlorin
2.	Proteins (Proteins, Gene)
3.	Iron
4.	Mixed Function Oxygenases (Monooxygenases)