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ICI 109,081

inhibits maturation of follicular oocytes in presence of gonadotropins without affecting ovulation in mice

Also Known As:

6-(4'-aminophenyl)-4,5-dihydro-5-methylpyridazin-3-one

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyridazines: 11
    - ICI 109,081: 1

Related Diseases

1.	Polyploidy 05/01/1988 - "In contrast, the majority of aberrations induced by ICI 109,081 were observed in females dosed 12 h PO where 10% of the embryos were polyploid and 3% were aneuploid." 05/01/1988 - "Colcemid and ICI 109,081 induced both polyploid and aneuploid embryos; with colcemid these aberrations were only observed in the embryos derived from oocytes of females dosed 3 h PO. "
2.	Aneuploidy (Aneuploid) 05/01/1988 - "In contrast, the majority of aberrations induced by ICI 109,081 were observed in females dosed 12 h PO where 10% of the embryos were polyploid and 3% were aneuploid." 05/01/1988 - "Colcemid and ICI 109,081 induced both polyploid and aneuploid embryos; with colcemid these aberrations were only observed in the embryos derived from oocytes of females dosed 3 h PO. "

Related Drugs and Biologics

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