4-aminodiphenylamine (Semidine)

RN given refers to parent cpd

Also Known As:

Semidine; 4-aminodiphenylamine monohydrochloride; 4-aminodiphenylamine sulfate; 4-aminodiphenylamine sulfate (2:1); N-phenyl-1,4-benzenediamine; N-phenyl-p-phenylenediamine; p-aminodiphenylamine; p-anilinoaniline; para-aminodiphenylamine

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amines: 4871
  - Polyamines: 3918
    - Diamines: 518
      - Phenylenediamines: 6
        4-aminodiphenylamine: 5
  - Aniline Compounds: 46
    - Phenylenediamines: 6
      - 4-aminodiphenylamine: 5

Experts

1.	Bruze, Magnus: 2 articles (07/2013 - 09/2012)
2.	Isaksson, Marlene: 2 articles (07/2013 - 09/2012)
3.	Malinauskiene, Laura: 2 articles (07/2013 - 09/2012)
4.	Ryberg, Kristina: 2 articles (07/2013 - 09/2012)
5.	Zimerson, Erik: 2 articles (07/2013 - 09/2012)

Related Diseases

1.	Hypersensitivity (Allergy) 09/01/2012 - "We show that it is possible that the major sensitizers in contact allergy to DO1 and DY3 are their metabolites, p-aminodiphenylamine and 2-amino-p-cresol, respectively, which might be formed by the azoreductase pathway of skin bacteria." 07/01/2013 - "Simultaneous contact allergies to Disperse Orange 1, 4-nitroaniline and p-aminodiphenylamine (PADPA), as well as to other disperse azo dyes and to p-phenylenediamine (PPD), have been reported. "
2.	Carcinogenesis 01/01/2022 - "We have recently reported that o-Tol and o-Ans are metabolically converted in vitro and in vivo to cytotoxic and mutagenic p-semidine-type dimers, namely 2-methyl-N4-(2-methylphenyl) benzene-1,4-diamine (MMBD) and 2-methoxy-N4-(2-methoxyphenyl) benzene-1,4-diamine (MxMxBD), respectively, suggesting their roles in urinary bladder carcinogenesis. "
3.	Neoplasms (Cancer) 01/01/1978 - "Sufficient numbers of rats and mice of each sex were at risk for the development of late-appearing tumors; however, the shortened period used for administering N-phenyl-p-phenylenediamine to the mice may not have been adequate for determining the carcinogenic potential of the test chemical in this species. "
4.	Body Weight (Weight, Body) 02/01/1992 - "Intraperitoneal administration of p-aminodiphenylamine (p-ADPA), an aromatic amine of wide industrial applications, / 42.5 mg/kg body weight for 180 days significantly decreased the activities of testicular lactate dehydrogenase and hyaluronidase and lactic acid content indicating arrest of spermatogenesis. "
5.	Arrest of spermatogenesis 02/01/1992 - "Intraperitoneal administration of p-aminodiphenylamine (p-ADPA), an aromatic amine of wide industrial applications, / 42.5 mg/kg body weight for 180 days significantly decreased the activities of testicular lactate dehydrogenase and hyaluronidase and lactic acid content indicating arrest of spermatogenesis. "

Related Drugs and Biologics

1.	Lactic Acid (Lactate)
2.	Tuberculin (PPD)
3.	L-Lactate Dehydrogenase (Lactate Dehydrogenase)
4.	Hyaluronoglucosaminidase (Hyaluronidase)
5.	Azo Compounds
6.	Amines
7.	Disperse Orange 1
8.	2-amino-4-methylphenol
9.	N(3)-(bromoacetyl)-2,3-diaminopropanoic acid
10.	4-phenylenediamine (p-phenylenediamine)