octanoic acid (caprylic acid)

RN given refers to parent cpd; structure in Merck Index, 9th ed, #1764

Also Known As:

caprylic acid; octanoate; caprylic acid, 14C-labeled; caprylic acid, aluminum salt; caprylic acid, ammonia salt; caprylic acid, barium salt; caprylic acid, cadmium salt; caprylic acid, calcium salt; caprylic acid, cesium salt; caprylic acid, chromium(+2) salt; caprylic acid, cobalt salt; caprylic acid, copper salt; caprylic acid, copper(+2) salt; caprylic acid, iridum(+3) salt; caprylic acid, iron(+3) salt; caprylic acid, lanthanum(+3) salt; caprylic acid, lead(+2) salt; caprylic acid, lithium salt; caprylic acid, manganese salt; caprylic acid, nickel(+2) salt; caprylic acid, potassium salt; caprylic acid, ruthenium(+3) salt; caprylic acid, sodium salt; caprylic acid, sodium salt, 11C-labeled; caprylic acid, tin salt; caprylic acid, tin(+2) salt; caprylic acid, zinc salt; caprylic acid, zirconium salt; caprylic acid, zirconium(+4) salt; lithium octanoate; sodium caprylate; sodium octanoate

Networked: 257 relevant articles (16 outcomes, 37 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	León, Guillermo: 4 articles (01/2021 - 12/2006)
2.	Hallett, Mark: 4 articles (01/2018 - 07/2012)
3.	Haubenberger, Dietrich: 4 articles (01/2018 - 07/2012)
4.	Xu, Qing: 3 articles (02/2022 - 01/2017)
5.	Zhang, Yong: 3 articles (02/2022 - 01/2017)
6.	Tack, Jan: 3 articles (01/2022 - 09/2007)
7.	Herrera, María: 3 articles (01/2021 - 11/2010)
8.	Williams, Robin S B: 3 articles (01/2021 - 01/2015)
9.	Gutiérrez, José María: 3 articles (02/2012 - 12/2006)
10.	Carbone, Florencia: 2 articles (01/2022 - 01/2019)

Related Diseases

1.	Inflammation (Inflammations) 02/20/2022 - "This study aimed to investigate the effects of caprylic acid (C8:0) on lipid metabolism and inflammation, and examine the mechanisms underlying these effects in mice and cells. " 01/01/2023 - "Octanoic acid (OA), a lipid oil that is mainly metabolized in the astrocytes of the brain, is a promising treatment for this type of injury owing to its potential functions against oxidative stress, apoptosis, inflammation, and ability to stabilize mitochondria. " 06/01/2021 - "Caprylic acid ameliorates rotenone induced inflammation and oxidative stress in the gut-brain axis in Zebrafish." 03/06/2023 - "Our previous studies have found that caprylic acid (C8:0) can improve blood lipids and reduce inflammation levels and may be related to the upregulation of the p-JAK2/p-STAT3 pathway by ABCA1. " 06/01/2021 - "In this study, we aimed to evaluate the effects of caprylic acid, in neurotoxin exposed zebrafish focusing on the relationship between intestinal and brain oxidative stress and inflammation. "
2.	Infections 01/03/2020 - "Contents of methyl ester increased significantly after infection, but that of other esters, especially octanoic acid decyl ester/OADE, decreased on the 5th day after infection. " 01/01/2018 - "Growth of the X. campestris pv. campestris ΔfabG1 strain overexpressing fabG2 required fabH for growth with octanoic acid, indicating that octanoyl coenzyme A is elongated by X. campestris pv. campestrisfabH Deletion of fabG2 reduced DSF family signal production, whereas overproduction of either FabG1 or FabG2 in the ΔfabG2 strain restored DSF family signal levels.IMPORTANCE Quorum sensing mediated by DSF signaling molecules regulates pathogenesis in several different phytopathogenic bacteria, including Xanthomonas campestris pv. campestris DSF signaling also plays a key role in infection by the human pathogen Burkholderia cepacia The acyl chains of the DSF molecules are diverted and remodeled from a key intermediate of the fatty acid synthesis pathway. " 01/01/2011 - "Caprylic acid in the effective treatment of intractable medical problems of frequent urination, incontinence, chronic upper respiratory infection, root canalled tooth infection, ALS, etc., caused by asbestos & mixed infections of Candida albicans, Helicobacter pylori & cytomegalovirus with or without other microorganisms & mercury." 01/01/2011 - "Thus, Caprylic acid is superior to & less expensive than Diflucan, & has potential application for anti-cancer, anti-aging, anti-Alzheimer's disease, anti-Autism, anti-infection, & general circulatory improvement." 08/05/2016 - "In conclusion, the combined application of caprylic acid, organic iron and mannan oligosaccharide can significantly affect the evolution of infection with S. "
3.	Essential Tremor (Essential Tremors) 03/05/2013 - "To assess safety and efficacy of an oral, single, low dose of octanoic acid (OA) in subjects with alcohol-responsive essential tremor (ET). " 04/01/2016 - "Dose-escalation study of octanoic acid in patients with essential tremor." 03/05/2013 - "Octanoic acid in alcohol-responsive essential tremor: a randomized controlled study." 01/01/2018 - "To investigate the effect of octanoic acid (OA) on the peripheral component of tremor, as well as OA's differential effects on the central and peripheral tremor component in essential tremor (ET) patients. " 01/01/2018 - "The response of the central and peripheral tremor component to octanoic acid in patients with essential tremor."
4.	Neoplasms (Cancer) 09/01/2019 - "[Synthesis and anti-tumor activity of ginsenoside Rh_2 caprylic acid monoester]." 08/15/2010 - "Furthermore, both ioxynil and its derivative ioxynil octanoate have been reported to induce tumors in animal bioassays. " 06/01/1998 - "Plagiochiline-A-15-yl octanoate and 14-hydroxyplagiochiline-A-15-yl 2E,4E-dodecadienoate showed significant cytotoxicity against P-388 murine leukemia tumor cells, both compounds exhibiting an ID50 of 0.05 microgram/ml. Plagiochiline A also showed cytotoxic activity. " 09/01/2019 - "Therefore,to improve stronger anti-tumor activity and attenuate toxicity,it was essential to design and optimize chemical structure of ginsenoside Rh_2. Through n-octanoylchloride modifications,a novel ester derivative of ginsenoside Rh_2 named caprylic acid monoester of Rh_2( C-Rh_2) was designed and synthesized. " 04/05/2019 - "This work describes the synthesis and some biological properties of a "triple-action" prodrug that releases in cancer cells cisplatin and two different epigenetically acting moieties, octanoate and phenylbutyrate. "
5.	Ischemia 12/23/2021 - "Here, we examined the effect of different carbon sources that are involved in the major metabolic pathways of acetyl-CoA synthesis on myocardial infarction and found that elevation of acetyl-CoA by sodium octanoate (8C) significantly improved heart function in ischemia reperfusion (I/R) rats. " 05/01/2013 - "This study employed Langendorff perfused hearts to investigate the impact of cardiac injury modeled by ischemia/reperfusion and, in a separate set of perfusions, the effects of elevated lipid (typically observed in obesity and type II diabetes) by perfusing with increased fatty acid concentrations (1mM octanoate). " 05/01/2005 - "Rat cardiomyocytes were submitted to a 2.5 h simulated ischemia followed by a 2 h reoxygenation without substrate (control), or with either glucose, octanoic acid, oleic acid, or elaidic acid. " 07/01/2000 - "Hearts isolated from fasted or fed rats were submitted to no-flow ischemia followed by reperfusion with buffer containing 8 mM glucose and either 0.4 mM palmitate or 0.8 mM octanoate. "

Related Drugs and Biologics

1.	Fatty Acids (Saturated Fatty Acids)
2.	Lipids
3.	Acetates (Acetic Acid Esters)
4.	Volatile Fatty Acids
5.	monooctanoin (Moctanin)
6.	Monoglycerides
7.	Anti-Bacterial Agents (Antibiotics)
8.	Thymol
9.	Volatile Oils (Essential Oils)
10.	linalyl acetate

Related Therapies and Procedures

1.	Cardiopulmonary Resuscitation (CPR)
2.	Drug Therapy (Chemotherapy)
3.	Ketogenic Diet
4.	Intraperitoneal Injections
5.	Fundoplication