pepstatin (pepstatin A)

01/17/2019 - "The nanoparticles were loaded with pepstatin A, and then the nanoparticles were incubated with cancer cells. "
07/01/1989 - "Evaluation of antitumor and antimetastatic activity of pepstatin A in some experimental tumor models."
07/01/1979 - "In MM46, CCM and NTF tumor strains there was also a decrease in the tumor cell numbers following pepstatin treatment. "
07/01/1977 - "The effect of pepstatin on the kinetics of ascitic fluid accumulation in L1210 tumor-bearing mice (DBA/2) was observed. "
03/01/1994 - "Pepstatin induced a marked decrease in the number of spontaneous metastasis in MCa or M5076 tumor bearing mice. "

02/01/2006 - "In the present study, we examined the effect of pepstatin, a specific inhibitor of pepsin, on acid reflux esophagitis. "
02/01/2006 - "These results suggest that pepstatin is highly effective against acid reflux esophagitis, without influencing acid secretion, while L-glutamine aggravated these lesions by increasing the pepsin activity by shifting the intraluminal pH to the optimal pH range for proteolytic action. "
02/01/2006 - "Acid reflux esophagitis was induced in rats by ligating both the pylorus and the forestomach for 3 or 4 hr. Pepstatin, ecabet Na (the anti-ulcer drug), and L-glutamine were administered intragastrically after the ligation. "

05/01/1975 - "The treatment of cells with pepstatin at various times possibly retards the early stage of infection with murine sarcoma virus."
01/01/1990 - "In mice with M5076 sarcoma the combination of pepstatin A and adriamycin resulted in antimetastatic activity significantly greater than that observed with each agent alone. "
03/01/1994 - "The effects of E-64 (Cathepsin B and L inhibitor) and Pepstatin A (Cathepsin D inhibitor) on spontaneous and experimental metastasis formation were investigated in mice with MCa mammary carcinoma, M5076 ovarian sarcoma and L1210 leukemia. "

03/01/1994 - "Pepstatin induced a marked decrease in the number of spontaneous metastasis in MCa or M5076 tumor bearing mice. "
03/01/1994 - "However, other pharmacological activities which may account for the discrepant effects of E-64 or Pepstatin on experimental and spontaneous metastasis cannot be ruled out."
03/01/1994 - "On the other hand, both these agents were unable to prevent the formation of experimental metastasis in mice injected i.v. with L1210, MCa or M5076 tumor cells or with tumor cells in which Cathepsin B, L and D activities were inhibited by a 24 hour continuous exposure to high non-cytotoxic concentrations of E-64 and/or Pepstatin. "
03/01/1994 - "Effects of E-64 (cysteine-proteinase inhibitor) and pepstatin (aspartyl-proteinase inhibitor) on metastasis formation in mice with mammary and ovarian tumors."
03/01/1994 - "The effects of E-64 (Cathepsin B and L inhibitor) and Pepstatin A (Cathepsin D inhibitor) on spontaneous and experimental metastasis formation were investigated in mice with MCa mammary carcinoma, M5076 ovarian sarcoma and L1210 leukemia. "

04/01/2000 - "In the present study the activity of a newly discovered acidic lysosomal pepstatin-insensitive proteinase (CLN2p) was measured in breast tissues by the most sensitive and highly specific assay that we had developed for the diagnosis of late-infantile neuronal ceroid lipofuscinosis (LINCL) (2). "
04/02/1999 - "A recent study has shown mutations in CLN2 gene, that encodes a novel lysosomal pepstatin-insensitive proteinase (LPIP), in the pathophysiology of late-infantile neuronal ceroid lipofuscinosis (LINCL). "
07/01/2001 - "Diagnosis of late-infantile neuronal ceroid lipofuscinosis: a new sensitive method to assay lysosomal pepstatin-insensitive proteinase activity in human and animal specimens by capillary electrophoresis."
01/01/2000 - "A lysosomal pepstatin-insensitive proteinase (CLN2p) deficiency is the underlying defect in the classical late-infantile neuronal ceroid lipofuscinosis (LINCL, CLN2). "
01/01/2000 - "Purification and characterization of bovine brain lysosomal pepstatin-insensitive proteinase, the gene product deficient in the human late-infantile neuronal ceroid lipofuscinosis."