stigmast-7-enol

RN given refers to (3beta)-isomer; structure in first source

Also Known As:

22,23-dihydrospinasterol; delta(7)-stigmastenol; schottenol; stigmast-7-en-3-ol; stigmast-7-enol, (3beta,5alpha)-isomer; stigmast-7-enol, (3beta,5alpha,24S)-isomer

Networked: 3 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Related Diseases

1.	Inflammation (Inflammations) 01/11/2023 - "In this study, we explored the effects of two major argan oil (AO) phytosterols, Schottenol (Schot) and Spinasterol (Spina), on oxidative stress, inflammation, and peroxisomal dysfunction in two murine microglial BV-2 cell lines, wild-ype (Wt) and Acyl-CoA oxidase 1 (Acox1)-deficient cells challenged with LPS treatment. "
2.	Diabetes Complications 01/01/2022 - "The top 10 enrichment items of BP annotations included response to lipopolysaccharide, response to molecule of bacterial origin, response to extracellular stimulus, etc. CC was mainly enriched in membrane raft, membrane microdomain, plasma membrane raft, etc. The MF of LTD analysis on DKD was predominately involved in nuclear receptor activity, ligand-activated transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor binding, etc. The involvement signaling pathway of LTD in the treatment of DKD included AGE-RAGE signaling pathway in diabetic complications, IL-17 signaling pathway, insulin resistance, TNF signaling pathway, etc. Molecular docking results showed that kaempferol, triptolide, nobiletin, and schottenol had a strong binding ability to PTGS2 and RELA. "
3.	Insulin Resistance 01/01/2022 - "The top 10 enrichment items of BP annotations included response to lipopolysaccharide, response to molecule of bacterial origin, response to extracellular stimulus, etc. CC was mainly enriched in membrane raft, membrane microdomain, plasma membrane raft, etc. The MF of LTD analysis on DKD was predominately involved in nuclear receptor activity, ligand-activated transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor binding, etc. The involvement signaling pathway of LTD in the treatment of DKD included AGE-RAGE signaling pathway in diabetic complications, IL-17 signaling pathway, insulin resistance, TNF signaling pathway, etc. Molecular docking results showed that kaempferol, triptolide, nobiletin, and schottenol had a strong binding ability to PTGS2 and RELA. "
4.	Breast Neoplasms (Breast Cancer) 01/01/2023 - "Five substances, 2,3-Diphenyl quinoxaline, 17-Acetoxy pregnolone, Benzyl-d-glucoside, Ergostenol acetate, and Stigmast-7-en-3-ol, shown higher binding affinity than Tamoxifen, signaling their potential use in breast cancer treatment."

Related Drugs and Biologics

1.	Acyl-CoA Oxidase
2.	Phytosterols (Plant Sterols)
3.	argan oil
4.	spinasterol
5.	Cyclooxygenase 2 (Cyclooxygenase-2)
6.	Interleukin-17 (Interleukin 17)
7.	Cytoplasmic and Nuclear Receptors (Nuclear Receptors)
8.	Transcription Factors (Transcription Factor)
9.	Tamoxifen
10.	RNA Polymerase II (RNA Polymerase B)