2-amino-7-phosphonoheptanoic acid

(D)-isomer active as an antagonist of N-methyl-D-aspartate excitation of central neurons; (L)-isomer inactive; RN given refers to cpd without isomeric designation

Also Known As:

(+--)-2-amino-7-phosphonoheptanoic acid; 2-amino-7-phosphoheptanoic acid; 2-amino-7-phosphonoheptanoic acid, (+-)-isomer; 2-amino-7-phosphonoheptanoic acid, (R)-isomer; 2-amino-7-phosphonoheptanoic acid, (S)-isomer; AP-7; AP-7 compound; D-AP7; Heptanoic acid, 2-amino-7-phosphono-, (+-)-

Networked: 42 relevant articles (1 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Amino Acids: 30675
  - Branched-Chain Amino Acids: 2289
    - Valine: 1999
      - 2-Amino-5-phosphonovalerate: 94
        2-amino-7-phosphonoheptanoic acid: 42
  - Phosphoamino Acids: 1
    - 2-Amino-5-phosphonovalerate: 94
      - 2-amino-7-phosphonoheptanoic acid: 42

Experts

1.	Fornai, Francesco: 2 articles (01/2005 - 06/2003)
2.	Fernandes, Gabriel Gripp: 1 article (01/2019)
3.	Frias, Alana Tercino: 1 article (01/2019)
4.	Pinheiro, Lucas C: 1 article (01/2019)
5.	Spiacci, Ailton: 1 article (01/2019)
6.	Tanus-Santos, José Eduardo: 1 article (01/2019)
7.	Zangrossi, Hélio: 1 article (01/2019)
8.	Eidi, Akram: 1 article (05/2012)
9.	Haeri-Rohani, Ali: 1 article (05/2012)
10.	Khakpai, Fatemeh: 1 article (05/2012)

Related Diseases

1.	Seizures (Absence Seizure) 09/24/1982 - "Protection against chemically induced seizures by 2-amino-7-phosphonoheptanoic acid." 02/28/1986 - "2-Amino-7-phosphonoheptanoic acid (2-APH) infusion into entopeduncular nucleus protects against limbic seizures in rats." 01/01/2002 - "[Inhibition of metaphit-induced audiogenic seizures by 2-amino-7-phosphonoheptanoic acid]." 12/01/2001 - "We examined the effects of regional infusions of 2-amino-7-phosphonoheptanoic acid (AP7) into the substantia nigra pars reticulata (SNR) in adult male rats on flurothyl-induced clonic seizures. " 11/01/1998 - "In contrast, focal pretreatment of MD with a competitive antagonist of the NMDA receptor 2-amino-7-phosphonoheptanoic acid (500 pmol) did not attenuate seizures. "
2.	Epilepsy (Aura) 12/01/1997 - "The effect of the competitive antagonist of the N-methyl-D-aspartate (NMDA) receptor, (+/-)2-amino-7-phosphonoheptanoic acid (APH) on electrocorticographic (ECoG) activity and behavior was studied in the model of epilepsy induced by systemic application of metaphit (1-(1-(3-isothiocyanatophenyl)-cyclohexyl)-piperidine). " 01/01/2002 - "The anticonvulsant potency of the competitive antagonist of the N-methyl-D-aspartate (NMDA) receptor, 2-amino-7-phosphonoheptanoic acid (APH) was investigated in the model of epilepsy induced by systemic administration of metaphit (1-(1-(3-isothiocyanatophenyl)-cyclohexyl)-piperidine). " 05/01/1999 - "The present study evaluated this possibility in genetically-epilepsy prone rats (GEPR-9s) by examining the effects of bilateral focal microinjection of a competitive NMDA receptor antagonist (DL-2-amino-7-phosphonoheptanoic acid (AP7), 1 and 5 nmol/side), a GABA(A) agonist (gaboxedol (THIP), 10 and 15 nmol) or an opioid peptide receptor antagonist (naloxone, 5 nmol) into PAG, based on the proposed role of these receptors in PAG neurotransmission. "
3.	Hypothermia 06/01/1998 - "The present study evaluated whether serotonergic (methysergide: 5-10 microg) or competitive [AP7 (2-amino-7-phosphonoheptanoic acid): 0.01-0.1 microg] or non-competitive [MK-801 (dizocilipine maleate): 0.3-3 microg] NMDA antagonists in the RVM altered CCWS and ICWS analgesia and hypothermia as well as basal nociceptive latencies. "
4.	Hyperalgesia 09/01/1997 - "AP-7 (an NMDA antagonist) on strychnine allodynia. " 09/01/1997 - "Comparable dose-dependent inhibition of AP-7 sensitive strychnine-induced allodynia and paw pinch-induced nociception by mexiletine in the rat." 06/01/2001 - "Pretreatment with either the EP(1)- receptor antagonist, SC-51322, the cyclooxygenase (COX)-2 selective inhibitor, NS-398, or the NMDA-receptor antagonist, AP-7, inhibited BIC-allodynia in a dose-dependent manner. " 04/18/1997 - "Subsequent intra-articular injection of either an NMDA or a non-NMDA glutamate receptor antagonist ((+/-)-2-amino-7-phosphonoheptanoic acid (AP7), 0.2 mM) or 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX), 0.1 mM) attenuated the thermal hyperalgesia and the mechanical allodynia produced by glutamate/aspartate/arginine. "
5.	Tremor (Tremors) 07/27/1984 - "2-Amino-7-phosphonoheptanoic acid raises the onset pressure for all three phases of HPNS in fed rats, but only for tremor and convulsions in fasted rats. " 07/27/1984 - "tremor, myoclonus and convulsions, successively appear, have been studied in fed and fasted rats with and without pretreatment with 2-amino-7-phosphonoheptanoic acid (180 mg/kg). " 10/15/1984 - "These and earlier data with 2-amino-7-phosphonoheptanoic acid suggest that excitation at the N-methyl-D-aspartate receptor is important in HPNS tremor, and that excitation at the quisqualate receptor contributes to HPNS convulsions."

Related Drugs and Biologics

1.	N-Methylaspartate (NMDA)
2.	Dizocilpine Maleate (Dizocilpine)
3.	N-Methyl-D-Aspartate Receptors (NMDA Receptors)
4.	gamma-Aminobutyric Acid (GABA)
5.	Opioid Peptides (Opioid Peptide)
6.	Naloxone (Narcan)
7.	Methysergide (Sansert)
8.	maleic acid (maleate)
9.	gaboxadol (THIP)
10.	Excitatory Amino Acid Antagonists

Related Therapies and Procedures

1.	Analgesia
2.	Injections
3.	Vagotomy
4.	Intra-Articular Injections