|1.||Takei, Mineo: 5 articles (03/2015 - 09/2003)|
|2.||Yoshinaga, Koji: 5 articles (03/2015 - 01/2002)|
|3.||Emori, Yutaka: 4 articles (09/2004 - 01/2002)|
|4.||Oka, Hideki: 3 articles (01/2004 - 01/2002)|
|5.||Sasaki, Hidetaka: 3 articles (01/2004 - 01/2002)|
|6.||Shiraishi, Yumiko: 3 articles (01/2004 - 01/2002)|
|7.||Ohira, Yuta: 2 articles (03/2015 - 01/2014)|
|8.||Tanaka, Takao: 2 articles (03/2015 - 01/2014)|
|9.||Katsunuma, Kokichi: 2 articles (03/2015 - 01/2014)|
|10.||Seto, Koichi: 2 articles (03/2015 - 01/2014)|
11/01/1999 - "This regulatory effect of Z-100 was eliminated by depletion of adherent cells from splenocytes derived from tumor bearing mice, and by the treatment with 2-ClAdo (a macrophage inhibitor). "
09/01/2006 - "Randomized phase II study of immunomodulator Z-100 in patients with stage IIIB cervical cancer with radiation therapy."
01/20/1989 - "[Experimental study of the antitumor effect of Z-100 in the treatment of MM46 tumor transplanted in C3H/He mice. "
10/20/1988 - "[Experimental study of the antitumor effect of Z-100 in the treatment of MM 46 tumor transplanted in C3H/He mice. "
05/01/2014 - "Z-100 showed a trend of improvement on OS in locally advanced cervical cancer, although the statistical power was less than anticipated because survival rates were unexpectedly higher than expected for both arms. "
06/01/1990 - "These results suggested that Z-100 is clinically useful for the treatment of leukopenia caused by radiotherapy."
06/01/1990 - "[An early clinical study of Z-100 in leukopenia caused by radiotherapy]."
06/01/1990 - "The clinical efficacy of Z-100 for the treatment of leukopenia caused by radiotherapy for malignant tumors was evaluated in an early clinical study using three doses, 2, 10 and 20 micrograms. "
08/25/1990 - "[Clinical efficacy of Z-100 for the treatment of leukopenia caused by radiotherapy--a multi-center double-blind comparative study with L-cysteine]."
08/25/1990 - "[Clinical efficacy of Z-100 for the treatment of leukopenia caused by radiotherapy--a multi-center double-blind comparative study with inosine]."
|3.||Melanoma (Melanoma, Malignant)
09/01/2003 - "The administration of Z-100 (10 mg/kg i.p.) in C57BL/6 mice bearing B16F10 melanoma improved the balance of Th1/Th2 cell responses from the Th2-dominant state to the normal state. "
01/01/2004 - "In this study, the effects of combination therapy consisting of X-ray irradiation and Z-100 on the survival time of C57BL/6 mice inoculated with B16F10 melanoma were investigated. "
01/01/2014 - "C57BL/6N mice injected subcutaneously with B16-BL6 melanoma cells in the right hind footpad were administered Z-100 subcutaneously in the right inguinal region on a daily basis. "
01/01/2004 - "Survival time was significantly prolonged in B16F10 melanoma-bearing mice treated with the X-ray irradiation (5 Gy) and Z-100 (10 mg/kg s.c.) combination therapy compared with mice irradiated with X-rays alone. "
01/01/2014 - "Z-100, an immunomodulatory extract of Mycobacterium tuberculosis strain Aoyama B, prevents spontaneous lymphatic metastasis of B16-BL6 melanoma."
|4.||Neoplasm Metastasis (Metastasis)
01/01/2002 - "The suppressive effects of Z-100 on pulmonary metastasis and restoration of Th1/Th2 cell responses were eliminated by the administration of anti-IFN-gamma mAb. Moreover, the suppressive effects of Z-100 on glucocorticoid-genesis were eliminated by the administration of anti-IFN-gamma-mAb. These results suggest that Z-100 restores the balance of Th1/Th2 cell responses via the suppression of glucocorticoid-genesis by Z-100-induced IFN-gamma. "
01/01/2014 - "The combination of low dose Z-100 and irradiation also inhibited spontaneous lymph node metastases. "
01/01/2014 - "Results showed that Z-100 reduced number of animals with metastasis, with respective metastasis rates of 85.7%, 42.9%, 7.1% and 0.0% in saline, 0.1 mg/kg Z-100, 1 mg/kg Z-100 and 10 mg/kg Z-100 group. "
01/01/1996 - "However, splenocytes from 3LL-bearing mice treated with Z-100 did not affect the development of pulmonary metastasis. "
01/01/1996 - "In the present study, anti-metastatic effect of Z-100 on the spontaneous pulmonary metastases of Lewis lung carcinoma (3LL) was examined in an attempt to regulate suppressor T cells. "
09/01/2004 - "These findings suggest that Z-100 might be a useful immunomodulator for control of HIV-1 infection."
09/01/2004 - "Z-100 was found to inhibit HIV-1 expression, even when added 24 h after infection. "
06/01/1994 - "However, the increased susceptibility of TI mice to infection was effectively counteracted to the levels observed in N mice when treated with Z-100 (10 mg/kg i.p.; 1, 3 and 5 days after thermal injury). "
01/01/1990 - "We investigated the effect of Z-100, a polysaccharide-rich extract from Mycobacterium tuberculosis strain Aoyama B, on the protection of immunocompromised mice against infection with Pseudomonas aeruginosa. "
01/01/1990 - "It was suggested that Z-100 is effective in the restoration of impaired resistance of immuno-compromised mice to bacterial infection possibly through a stimulation of phagocyte accumulation into the site of infection."
|3.||Interleukin-12 Subunit p40
|7.||antineoplaston A10 (A 10)
|8.||Interleukin-12 (IL 12)
|10.||Interleukin-4 (Interleukin 4)