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succinyl-alanyl-alanyl-prolyl-valine chloromethyl ketone
Also Known As:
SAAPVC; Suc-Ala-Ala-Pro-Val-chloromethyl ketone; L-Prolinamide, N-(3-carboxy-1-oxopropyl)-L-alanyl-L-alanyl-N-(3-chloro-1-(1-methylethyl)-2-oxopropyl)-, (S)-
Networked:
4
relevant articles (
0
outcomes,
1
trials/studies)
Bio-Agent Context: Research Results
Amino Acids, Peptides, and Proteins: 1
Amino Acids: 30675
Amino Acid Chloromethyl Ketones
succinyl-alanyl-alanyl-prolyl-valine chloromethyl ketone: 4
Related Diseases
1.
Emphysema
05/01/1989 - "
A study was undertaken to determine whether emphysema, induced in hamsters by intratracheal treatment with human neutrophil elastase (HNE), could be ameliorated by intratracheal instillation of succinyl-alanyl-alanyl-prolyl-valine-chloromethyl ketone (CMK).
"
07/01/1982 - "
Intratracheal administration of an elastase inhibitor (Succinyl alanyl alanyl prolyl valine chloromethyl ketone) into hamsters 20 days after induction of emphysema by porcine pancreatic elastase did not affect the lesion seen at 120 days.
"
07/01/1981 - "
The capacity of the synthetic elastase inhibitor, succinyl alanyl alanyl prolyl valine chloromethyl ketone (CMK), to moderate elastase-induced emphysema in hamsters was examined using morphometric and physiologic measurements.
"
07/01/1981 - "
The moderation of elastase-induced emphysema in the hamster by intratracheal pretreatment or post-treatment with succinyl alanyl alanyl prolyl valine chloromethyl ketone.
"
01/01/1984 - "
Neither EXT nor EXT treated with the elastase inhibitor suc-ala-ala-pro-val chloromethyl ketone (EXT + CMK), which had a residual elastolytic activity equivalent to 15 micrograms of HNE, produced emphysema; both preparations caused bronchial secretory cell metaplasia 21 days after treatment.
"
2.
Metaplasia
01/01/1984 - "
Neither EXT nor EXT treated with the elastase inhibitor suc-ala-ala-pro-val chloromethyl ketone (EXT + CMK), which had a residual elastolytic activity equivalent to 15 micrograms of HNE, produced emphysema; both preparations caused bronchial secretory cell metaplasia 21 days after treatment.
"
Related Drugs and Biologics
1.
Leukocyte Elastase (Neutrophil Elastase)
2.
Pancreatic Elastase (Elastase)
Related Therapies and Procedures
1.
Aftercare (After-Treatment)