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crotononitrile

RN given refers to cpd without isomeric designation

Also Known As:

2-butenenitrile; crotononitrile, (E)-isomer; crotononitrile, (Z)-isomer

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Nitriles: 227
  - crotononitrile: 3

Experts

1.	Llorens, Jordi: 2 articles (12/2005 - 03/2003)
2.	Boadas-Vaello, Pere: 1 article (12/2005)
3.	Riera, Judith: 1 article (12/2005)
4.	Balbuena, Eduardo: 1 article (03/2003)

Related Diseases

1.	Dyskinesias (Dyskinesia) 01/01/1990 - "The effect of crotononitrile (4.22 mmol/kg, CRN) or 2-pentenenitrile (2.00 mmol/kg, 2-PN), which exhibit long-term dyskinesia, was examined on the metabolism of serotonin (5-HT) and dopamine (DA) in five brain regions of mice 1, 5, 12 and 35 days after dosing with CRN or 2-PN or vehicle (0.1 ml/25 g). " 01/01/1990 - "Alterations in the metabolism of serotonin and dopamine in the central nervous system of mice displaying a persistent dyskinesia due to crotononitrile or 2-pentenenitrile."
2.	Gliosis 03/01/2003 - "In a dose-dependent manner, cis-crotononitrile induced vestibular dysfunction, corneal opacity, and hair cell loss in both vestibular epithelia and organ of Corti, and gliosis in retina, olfactory bulb, superior colliculus, inferior colliculus, hypothalamus, hippocampus, and cingulate cortex, but not in cerebellum or striatum. " 03/01/2003 - "Concentrations in retina and brain regions of glial fibrillary acidic protein, a marker for reactive gliosis, were also determined in rats exposed to cis-crotononitrile. "
3.	Corneal Opacity 03/01/2003 - "In contrast, trans-crotononitrile triggered rearing deficits but not vestibular dysfunction, hair cell loss, or corneal opacity. " 03/01/2003 - "In a dose-dependent manner, cis-crotononitrile induced vestibular dysfunction, corneal opacity, and hair cell loss in both vestibular epithelia and organ of Corti, and gliosis in retina, olfactory bulb, superior colliculus, inferior colliculus, hypothalamus, hippocampus, and cingulate cortex, but not in cerebellum or striatum. "
4.	Chorea (Rheumatic Chorea) 12/01/2005 - "Rats treated with IDPN, allylnitrile, and cis-crotononitrile developed the ECC (excitation with circling and choreiform movements) syndrome, whereas those treated with trans-crotononitrile and hexadienenitrile exhibited a different syndrome, characterized by faltering movements. "

Related Drugs and Biologics

1.	Serotonin (5 Hydroxytryptamine)
2.	Glial Fibrillary Acidic Protein
3.	Dopamine (Intropin)
4.	2-pentenenitrile
5.	allyl cyanide