neplanocin A

neplanocins are antitumor antibiotics & carbocyclic analogs of purine nucleosides from Ampullarilla regularis A11079; see also neplanocin B, neplanocin C, neplanocin D & neplanocin F; structure in first source; a potent inhibitor of S-adenosylhomocysteine hydrolase
Also Known As:
halo-neplanocin A; neplanocin A, hydrochloride, (1S-(1alpha,2alpha,5beta))
Networked: 19 relevant articles (3 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results


1. Johnson, Peter W M: 1 article (05/2011)
2. Crabb, Simon J: 1 article (05/2011)
3. Packham, Graham: 1 article (05/2011)
4. Hayden, Annette: 1 article (05/2011)
5. Lee, Kang Man: 1 article (11/2004)
6. Lee, Sang Kook: 1 article (11/2004)
7. Kim, Kyung Ran: 1 article (11/2004)
8. Lee, Hyun Joo: 1 article (11/2004)
9. Chun, Moon Woo: 1 article (11/2004)
10. Moon, Hyung Ryong: 1 article (11/2004)

Related Diseases

1. Vesicular Stomatitis
08/01/1989 - "Their selectivity was greater than that of neplanocin A, particularly against vesicular stomatitis virus and rotavirus. "
07/01/1985 - "In vivo, neplanocin A afforded only marginal protection against a lethal infection of mice with vesicular stomatitis virus."
05/31/1985 - "For a series of adenosine analogues a close correlation (r = 0.986) was found between their antiviral potency (against vesicular stomatitis virus) and their inhibitory effects (Ki/Km) on S-adenosylhomocysteine (AdoHcy) hydrolase; thus, in order of increasing inhibitory potency for both virus replication and AdoHcy hydrolase activity: (S)-9-(2,3-dihydroxypropyl)adenine less than (RS)-3-adenin-9-yl-2-hydroxypropanoic acid (isobutyl ester) less than carbocyclic 3-deazaadenosine less than neplanocin A. "
06/01/1989 - "(S)-9-(2,3-dihydroxypropyl)adenine, (RS)-3-adenin-9-yl-2-hydroxypropanoic acid, carbocyclic 3-deazaadenosine and neplanocin A, which have been previously recognized as specific inhibitors of S-adenosyl-L-homocysteine (SAH) hydrolase, gained a marked increase in their cytostatic activity (against tumor cells) and antiviral activity (against vaccinia and vesicular stomatitis virus) in the presence of L-homocysteine (10(-3) M). "
07/01/1985 - "Of a series of carbocyclic analogs of adenosine, in which the ribose moiety was replaced by a cyclopentenyl ring, neplanocin A, or (-)-9-[trans-2, trans-3-dihydroxy-4-(hydroxymethyl)cyclopent-4-enyl]adenine proved particularly effective in inhibiting the multiplication of DNA viruses (i.e., vaccinia), (-)RNA viruses (i.e., parainfluenza, measles, and vesicular stomatitis), and double-stranded RNA viruses (i.e., reo) in vitro in cell culture. "
2. Leukemia
3. Vaccinia
4. Paramyxoviridae Infections (Parainfluenza)
5. Measles

Related Drugs and Biologics

1. Adenosine
2. Adenine
3. Homocysteine
4. Adenosine Kinase
5. Double-Stranded RNA (RNA, Double Stranded)
6. Ribose (D-Ribose)
7. cyclodrine
8. 9-(2,3-dihydroxypropyl)adenine
9. beta-apocarotenoid-14',13'-dioxygenase (ADO)
10. Tubercidin

Related Therapies and Procedures

1. Life Support Care