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polyhemoglobin-pyridoxal-5-phosphate
artificial oxygen carrier model
Also Known As:
PLP-Hb; SFH-PLP; SFHB-PP; p-polyHb; poly Hb-PLP; poly SFH-P; polymerized pyridoxylated hemoglobin; pyridoxal phosphate modified hemoglobin; pyridoxalated polymerized hemoglobin; pyridoxalated polymerized stroma-free hemoglobin
Networked:
10
relevant articles (
2
outcomes,
2
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Amino Acids, Peptides, and Proteins: 1
Proteins: 484843
Blood Proteins: 12459
Hemoglobins: 37188
polyhemoglobin-pyridoxal-5-phosphate: 10
Hemeproteins: 194
Globins: 2716
Hemoglobins: 37188
polyhemoglobin-pyridoxal-5-phosphate: 10
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Pyridines: 88
Picolines: 14
Vitamin B 6: 1882
Pyridoxal: 372
Pyridoxal Phosphate: 308
polyhemoglobin-pyridoxal-5-phosphate: 10
Enzymes and Coenzymes: 1
Coenzymes: 558
Pyridoxal Phosphate: 308
polyhemoglobin-pyridoxal-5-phosphate: 10
Related Diseases
1.
Wounds and Injuries (Trauma)
11/01/1996 - "
Clinical trials have been completed successfully in volunteers and are now under way to assess the safety and efficacy of Poly SFH-P as a clinically useful red blood cell substitute for treatment of acute blood loss in the setting of trauma and surgery.
"
08/01/1997 - "
Thirty-nine patients received 1 (n = 14), 2 (n = 2), 3 (n = 15), or 6 (n = 8) units of Poly SFH-P instead of red cells as part of their blood replacement after trauma and urgent surgery.
"
03/01/1995 - "
Clinical trials have been completed successfully in volunteers, and are now underway to assess the safety and efficacy of Poly SFH-P as a clinically useful red cell substitute in the treatment of acute blood loss in the setting of trauma and surgery.
"
2.
Hemorrhagic Shock
12/01/1991 - "
Hemorrhagic shock (80% of blood volume, rat) gave definitive survival for 8 of the 14 animals tested with MPOE-PLP-Hb (57%) but only 3 of the 8 animals tested with POLY-PLP-Hb (38%).
"
05/01/1987 - "
Pyridoxalated polymerized stroma-free hemoglobin solution (SFHS-PP) as an oxygen-carrying fluid replacement for hemorrhagic shock in dogs.
"
3.
HTLV-I Infections (HTLV-I Infection)
01/01/1988 - "
Since transmission of HTLV-I occurs by cell to cell contact and is rare in cell-Free condition, it is unlikely that the PLP-Hb prepared from HTLV-I positive blood which is deprived of leukocytes transmits HTLV-I infection.
"
4.
Hemorrhage
11/01/1990 - "
Pyridoxalated polymerized hemoglobin (PPHG) has promise as a blood substitute for transfusing patients with hemorrhage.
"
5.
Hematuria
01/01/1989 - "
We attribute poly-PLP-Hb associated hematuria and high oxygen affinity to rapid elimination of these unpolymerized Hb species, leaving in the circulation the polymerized, less-highly pyridoxylated species with excessive oxygen-binding affinity.
"
01/01/1989 - "
However, hematuria and excessive oxygen-binding affinity have been associated with poly-PLP-Hb after transfusion.
"
Related Drugs and Biologics
1.
Blood Substitutes (Artificial Blood)
2.
Oxygen (Dioxygen)
3.
Tyrosine (L-Tyrosine)
4.
Solutions
5.
Oxalates
6.
Cystathionine