01/01/1985 - "The number of tumor-bearing animals and the time between the first injection and the tumor appearance were closely related to the dose of R 7000 injected. "
01/01/1985 - "In those to whom R 7000 was administered tumors began to appear at the site of the injection after the third month. "
01/01/1985 - "In animals which did not receive R 7000, no malignant tumor was observed. "
09/01/1986 - "R 7000 is a weak carcinogen at the concentration employed here, when compared to some nitrosamines used in the development of forestomach cancer in rodents. "
|2.||Squamous Cell Carcinoma (Epidermoid Carcinoma)
09/01/1986 - "7-methoxy-2-nitro-naphtho[2,1-b] furan (R 7000), known as a very potent mutagen and a very active in vivo carcinogen was employed here to develop squamous cell carcinoma in the rat. "
01/01/1986 - "Subcutaneous injections of 7-methoxy 2-nitro naphtho [2,1-b] furan (R 7000) in C3H mice induce subcutaneous fibrosarcomas at the site of injection and squamous cell carcinomas of the stomach."
|3.||Sarcoma (Soft Tissue Sarcoma)