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terminase

involved in assembly of lambda phage; cleaves vegetative concotemeric DNA to generate unit lambda chromosomes; terL encodes large subunit; terS encodes small subunit
Also Known As:
lambda DNA terminase
Networked: 37 relevant articles (1 outcomes, 1 trials/studies)

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Bio-Agent Context: Research Results

Experts

1. Cho, Carolyn R: 5 articles (01/2022 - 01/2018)
2. McCrea, Jacqueline B: 4 articles (01/2022 - 01/2018)
3. Menzel, Karsten: 4 articles (10/2019 - 01/2018)
4. Iwamoto, Marian: 3 articles (01/2022 - 01/2018)
5. Macha, Sreeraj: 3 articles (01/2022 - 01/2018)
6. Erb-Zohar, Katharina: 2 articles (01/2022 - 01/2022)
7. Fancourt, Craig: 2 articles (01/2022 - 01/2022)
8. Kropeit, Dirk: 2 articles (01/2022 - 01/2022)
9. Leavitt, Randi: 2 articles (01/2022 - 01/2020)
10. McCormick, David: 2 articles (01/2022 - 01/2022)

Related Diseases

1. Infections
04/01/2020 - "[The terminase complex, a relevant target for the treatment of HCMV infection]."
01/01/2016 - "To better understand the pervasiveness of EEDV (carrier or latent state of infection) in domesticated and wild Lake Trout populations, we developed a sensitive TaqMan quantitative PCR (qPCR) assay to detect the presence of the EEDV terminase gene in Lake Trout tissues. "
11/23/2020 - "Biochemical and structural studies of these mutants demonstrated that (i) four of the helices in the CVSC helix bundle can be attributed to two copies each of pUL36 and pUL25, (ii) pUL17 and pUL6 are required for capsid binding of the terminase complex in the nucleus, (iii) pUL17 is important for determining the site of the first cleavage reaction generating replicated genomes with termini derived from the long-arm component of the herpes simplex virus 1 (HSV-1) genome, (iv) pUL36 serves no direct role in cleavage/packaging, (v) cleavage and stable packaging of the viral genome involve an ordered interaction of the terminase complex and pUL25 with pUL17 at the portal vertex, and (vi) packaging of the viral genome results in a dramatic displacement of the portal.IMPORTANCE Herpes simplex virus 1 (HSV-1) is the causative agent of several pathologies ranging in severity from the common cold sore to life-threatening encephalitic infection. "
04/07/1995 - "Mutations in the gene 16 recombination sequence (3GA and 15TG) that eliminated Hp17 formation in T4 phage increased the synthesis of the large terminase subunit, gp17 in T4 infections, suggesting gp16 interaction with this site. "
01/01/2022 - "Letermovir is a human cytomegalovirus (CMV) terminase inhibitor approved in the United States, Canada, Japan, and the European Union for prophylaxis of CMV infection and disease in CMV-seropositive, allogeneic, hematopoietic stem-cell transplant recipients. "
2. Common Cold
3. Cytomegalovirus Infections (Inclusion Disease)
4. Virus Diseases (Viral Diseases)
5. Kaposi Sarcoma (Kaposi's Sarcoma)

Related Drugs and Biologics

1. HP17
2. letermovir
3. DNA (Deoxyribonucleic Acid)
4. Proteins (Proteins, Gene)
5. Viral DNA
6. Concatenated DNA
7. Member 1 Subfamily B ATP Binding Cassette Transporter
8. Holoenzymes
9. Glucuronosyltransferase (UDP Glucuronosyltransferase)
10. Ribonucleosides

Related Therapies and Procedures

1. Hematopoietic Stem Cell Transplantation
2. Cell Transplantation