adenosine 5'-O-(2-thiodiphosphate) (ADP-S)

partial agonist toward platelet aggregation; see also record for 1-thiodiphosphate cpd

Also Known As:

ADP-S; (32S)adenosine 5'-O-(2-thiodiphosphate); 5'-ADPS; 5'-adenosine diphosphate beta-S; ADP beta S; ADP beta-S; ADPbetaS; adenosine 5'-O-(2-thiodiphosphate), trilithium salt; adenosine-5'-O-(2-thiodiphosphate); beta-thio-ADP

Networked: 4 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	He, Li: 1 article (09/2017)
2.	Huang, Dujuan: 1 article (09/2017)
3.	Liu, XiaoHong: 1 article (09/2017)
4.	Niu, Juan: 1 article (09/2017)
5.	Tian, Hong: 1 article (09/2017)
6.	Xu, Tao: 1 article (09/2017)
7.	Yang, Junna: 1 article (09/2017)
8.	Yue, MingXia: 1 article (09/2017)
9.	Zeng, Junwei: 1 article (09/2017)
10.	Zhou, Rui: 1 article (09/2017)

Related Diseases

1.	Glomerulonephritis 12/01/1996 - "5. In previous studies of experimental mesangioproliferative glomerulonephritis, exogenously given ADP beta S and ATP gamma S have been shown to aggravate the course of the disease, while 2-chloroadenosine had beneficial effects. "
2.	Gliosis 08/01/2009 - "Therefore, the aim of the present study was to identify the role of the phosphoinositide 3 kinase (PI3-K/Akt) and the mitogen-activated protein kinase/extracellular signal regulated protein kinase (MAPK/ERK) pathways in P2Y receptor-mediated astrogliosis after traumatic injury and after microinfusion of ADP beta S (P2Y(1,12,13) receptor agonist) into the rat nucleus accumbens (NAc). "
3.	Pain (Aches) 09/12/2017 - "Moreover, intrathecal injection of AM1241 alleviates pain response and reduces the elevated expression of P2Y12 and P2Y13 receptors, p-p38MAPK, and NF-κBp65 in the dorsal spinal cord of ADPbetaS-treated rats. "
4.	Neuralgia (Stump Neuralgia) 09/12/2017 - "Chronic constriction injury (CCI) and intrathecal ADPbetaS injection were performed in rats to induce neuropathic pain. "
5.	Hypoxia (Hypoxemia) 08/01/2006 - "ATP released after hypotonic stress (200 mOsm/L) as well as P2YR agonists prevented hepatocyte killing by hypoxia with efficiency ranking UTP > ATPgammaS > ADPbetaS, whereas the P2XR agonist, methylene-adenosine-5'-triphosphate, was ineffective. "

Related Drugs and Biologics

1.	adenosine 5'-O-(3-thiotriphosphate)
2.	Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)
3.	Mitogen-Activated Protein Kinases
4.	2-Chloroadenosine (2 Chloroadenosine)
5.	Protein Kinases (Protein Kinase)
6.	Uridine Triphosphate (UTP)
7.	Adenosine Triphosphate (ATP)
8.	AM 1241

Related Therapies and Procedures

1.	Spinal Injections