|1.||Zhu, Hua: 2 articles (02/2012 - 12/2006)|
|2.||Thibodeaux, Brett A: 2 articles (02/2005 - 01/2005)|
|3.||O'Callaghan, Richard J: 2 articles (02/2005 - 01/2005)|
|4.||Willcox, Mark D P: 1 article (02/2012)|
|5.||Conibear, Tim C R: 1 article (02/2012)|
|6.||Flanagan, Judith L: 1 article (02/2012)|
|7.||Manos, Jim: 1 article (12/2006)|
|8.||Smith, Lucas: 1 article (12/2006)|
|9.||Rose, Barbara: 1 article (12/2006)|
|10.||Elkins, Mark: 1 article (12/2006)|
02/01/2012 - "aeruginosa strains isolated from ocular infections or inflammatory events produce very low levels of protease IV. The aim of the present study was to characterize, genetically and phenotypically, the presence and expression of the protease IV gene in a group of clinical isolates that cause adverse ocular events of varying degrees, and to elucidate the possible control mechanisms of expression associated with this virulence factor. "
02/01/2012 - "Expression of protease IV by Pseudomonas aeruginosa during ocular infections contributes significantly to tissue damage. "
07/03/1998 - "Comparisons of virulence between a Pseudomonas parent strain and an isogenic mutant devoid of protease IV have demonstrated a significant role for this enzyme during infection. "
03/01/1998 - "The effects of protease IV on the corneal virulence of the protease-IV-deficient strain, PA103-29::Tn9, were determined by injecting eyes with 1000 CFU of log phase bacteria plus either 200 ng active purified protease IV or 200 ng heat-inactivated protease IV. Changes in ocular disease, determined by slit-lamp examination, were measured at 3, 16, 22, and 27 hours after infection. "
07/01/1997 - "In the mouse model, eyes inoculated with the protease IV-producing parent strain had significant corneal damage as early as 24 hours after infection, whereas the protease IV-deficient mutant strain produced no significant corneal damage during 6 days of infection. "
07/01/1997 - "The protease IV-deficient strain PA103-29::Tn9 had significantly reduced corneal virulence relative to its parent strain PA103-29 in both a rabbit intrastromal model and a mouse topical model of infection. "
03/01/1996 - "Protease IV was found to be a novel Pseudomonas protease contributing to corneal virulence in rabbits and mice when infections were initiated at the corneal surface. "
03/01/1998 - "A Pseudomonas mutant deficient in protease IV has significantly reduced virulence in experimental keratitis. "
07/01/1997 - "Protease IV appears to mediate corneal virulence and should be considered as a target in the development of medications designed to minimize corneal damage during Pseudomonas keratitis."
07/01/1997 - "The role of protease IV in the pathogenesis of Pseudomonas aeruginosa keratitis was investigated by comparing a mutant strain completely deficient in protease IV activity with its protease IV activity-producing parent. "
03/01/1996 - "Furthermore, production of protease IV in low quantities was sufficient for virulence when the topical stages of keratitis were bypassed by an intrastromal injection of Pseudomonas."
02/01/2004 - "Pseudomonas keratitis: protease IV gene conservation, distribution, and production relative to virulence and other Pseudomonas proteases."
|4.||Demyelinating Diseases (Demyelinating Disease)
01/15/2005 - "Infection with wild-type Theiler's murine encephalomyelitis virus induces a late-onset, progressive T cell-mediated demyelinating disease, similar to MS. To determine the potential of virus-induced autoimmunity by molecular mimicry, a nonpathogenic neurotropic Theiler's murine encephalomyelitis virus variant was engineered to encode a mimic peptide from protease IV of Haemophilus influenzae (HI), sharing 6 of 13 aa with the dominant encephalitogenic proteolipid protein (PLP) epitope PLP(139-151). "
01/01/2005 - "SJL mice infected with TMEV containing PLP139-151 or a mimic of PLP139-151 expressed by the protease IV protein of Haemophilus influenzae, sharing only 6/13 amino acids with the native epitope, developed an early-onset demyelinating disease associated with activation of CD4+ T cells reactive with PLP139-151. "
|5.||Acute Lung Injury
|2.||Peptide Hydrolases (Proteases)
|3.||Pancreatic Elastase (Elastase)