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2-mercaptobenzimidazole

purine synthesis antimetabolite; RN given refers to parent cpd

Also Known As:

2-mercaptobenzimidazole, monosodium salt; 2-mercaptobenzimidazole, zinc (2:1) salt

Networked: 9 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzimidazoles: 245
      - 2-mercaptobenzimidazole: 9

Experts

1.	Durnev, A D: 2 articles (11/2000 - 03/2000)
2.	Zhanataev, A K: 2 articles (11/2000 - 03/2000)
3.	Abbas, Muzaffar: 1 article (05/2021)
4.	Imran, Muhammad: 1 article (05/2021)
5.	Javed, Ibrahim: 1 article (05/2021)
6.	Khan, Arif-Ullah: 1 article (05/2021)
7.	Malik, Nadia Shamshad: 1 article (05/2021)
8.	Munir, Muhammad Usman: 1 article (05/2021)
9.	Nadeem, Humaira: 1 article (05/2021)
10.	Rizwan, Muhammad: 1 article (05/2021)

Related Diseases

1.	Hyperlipidemias (Hyperlipidemia) 11/08/2022 - "Amino Acid Conjugates of 2-Mercaptobenzimidazole Ameliorates High-Fat Diet-Induced Hyperlipidemia in Rats via Attenuation of HMGCR, APOB, and PCSK9."
2.	Chromosome Aberrations (Chromosome Abnormalities) 03/01/2000 - "The chromosome aberration assay in the bone marrow cells of C57B1/6 mice showed that the new 2-mercaptobenzimidazole derivative afobazole(1-100 mg/kg) prevented manifestations of the clastogenic effects of dioxidine (100 mg/kg, i.p.) over a period of 24 h and reduced by 44-75% the cytogenetic effect of dioxidine (300 mg/kg, i.p.). " 11/01/2000 - "The influence of a new 2-mercaptobenzimidazole derivative afobazole on cytogenetic effects of dioxidine and cyclophosphamide was studied by counting chromosome aberrations in bone marrow cells of C57Bl/6 mice. "
3.	Bradycardia 05/01/1997 - "Experiments on anesthetized cats and rats showed that 2-mercaptobenzimidazole derivatives, known as SM-266 and SM-345, induced marked and long-term bradycardia, increased the stroke output, and reduced the requirements of the heart of oxygen. " 01/01/2009 - "Experiments in narcotized rats showed the new selective anxiolytic afobazole, a derivative of 2-mercaptobenzimidazole, to cause a small bradycardia with almost no effect on the important parameters of heart hemodynamics and cardiac performance such as the arterial pressure, cardiac output, and mean aorta blood flow acceleration. "
4.	Stroke (Strokes) 05/01/1997 - "Experiments on anesthetized cats and rats showed that 2-mercaptobenzimidazole derivatives, known as SM-266 and SM-345, induced marked and long-term bradycardia, increased the stroke output, and reduced the requirements of the heart of oxygen. "
5.	Inflammation (Inflammations) 05/01/2021 - "Together, our findings suggested that these synthetic 2-mercaptobenzimidazole derivatives are safer therapeutic candidates for inflammation."

Related Drugs and Biologics

1.	Apolipoproteins B (ApoB)
2.	Amino Acids
3.	2- ((2- morpholino)ethylthio)- 5- ethoxybenzimidazole
4.	Anti-Anxiety Agents (Anxiolytics)
5.	dioxidine
6.	Oxygen (Dioxygen)
7.	Cyclophosphamide (Cytoxan)