methylazoxymethanol

a neuroteratogen; reacts with guanine residues of DNA & RNA forming 7-methylguanine adduct products; carcinogenicity probably related to biological decomposition into methyldiazonium ion, the ultimate methylating agent; structure in first source

Also Known As:

Networked: 113 relevant articles (1 outcomes, 15 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Maćkowiak, Marzena: 5 articles (08/2021 - 02/2014)
2.	Micale, Vincenzo: 5 articles (01/2021 - 01/2017)
3.	Krebs, Marie-Odile: 5 articles (06/2011 - 06/2006)
4.	Le Pen, Gwenaëlle: 5 articles (06/2011 - 06/2006)
5.	Latusz, Joachim: 4 articles (01/2021 - 02/2014)
6.	Ruda-Kucerova, Jana: 4 articles (01/2021 - 01/2017)
7.	Babinska, Zuzana: 4 articles (11/2020 - 01/2017)
8.	Stark, Tibor: 4 articles (11/2020 - 01/2017)
9.	Colciaghi, Francesca: 4 articles (01/2020 - 09/2013)
10.	Nobili, Paola: 4 articles (01/2020 - 09/2013)

Related Diseases

1.	Neoplasms (Cancer) 02/26/1997 - "Because the incidence of colonic tumors induced by methylazoxymethanol (MAM) in rats was shown to be enhanced by X-irradiation, we immunohistochemically analyzed these colonic carcinomas for the presence of p53 gene mutations. " 01/01/1988 - "Primary colon tumors of different sizes and malignancy, chemically induced by methylazoxymethanol in outbred CF-1 mice, were used to investigate the antitumor effects of 5-Fluorouracil (5FU) and cis-diammine-dichloroplatinum (DDP), given weekly i.v. as single agents or in combination. " 08/01/1982 - "Selenium inhibits the development of 2-acetylaminofluorene-induced hepatic tumors and methylazoxymethanol-induced colon tumors. " 05/01/1982 - "Methylazoxymethanol is a potent carcinogen and induces tumors predominantly of the small intestine and colon following a single injection. " 05/01/1982 - "Inhibition of methylazoxymethanol-induced intestinal tumors in the rat by pyrazole with paradoxical effects on skin and kidney."
2.	Schizophrenia (Dementia Praecox) 01/01/2019 - "Methylazoxymethanol (MAM)-treated pregnant rat at gestation day (GD) 17 has been shown to be a valuable developmental animal model for schizophrenia. " 11/01/2018 - "To gain insight into this factor, we assessed the postnatal developmental trajectory of CB1R expression in the methylazoxymethanol (MAM) model of schizophrenia. " 01/01/2017 - "Reactivity to addictive drugs in the methylazoxymethanol (MAM) model of schizophrenia in male and female rats." 11/01/2015 - "Gestational day 17 methylazoxymethanol (MAM) treatment has been shown to reproduce, in rodents, some of the alterations in cortical and mesolimbic circuitries thought to contribute to schizophrenia. " 06/01/2011 - "Exposure to methylazoxymethanol (MAM) at embryonic day 17 (E17) in the rat has been proposed to be a promising model for schizophrenia that mimics behavioural abnormalities and deficits in prefrontal cortex (PFC) networks. "
3.	Body Weight (Weight, Body) 03/01/2007 - "Methylazoxymethanol (15 mg/kg body weight, day 43) was examined for comparison and caused similar hypoplasia of the guinea pig cerebellum, but did also induce a reduction in body weight. " 02/01/1994 - "In this study, daily body weights (postnatal days 1 to 60) were compared among the offspring of the following groups of Long Evans rats: dams fed liquid diet containing 35% EtOH-derived calories; their pair-fed and chow-fed controls; and dams exposed to methylazoxymethanol (MAM) in two previous studies, in which offspring exhibited reduced numbers of growth hormone releasing factor (GRF) neurons. " 01/01/1997 - "Intraperitoneal administration of methylazoxymethanol (MAM) acetate (0.05 microl/g of body weight) in male Sprague-Dawley rats aged 3 days produced cell death in the external granule layer of the cerebellum which peaked at 48 hours (h) and was followed by removal of cellular debris at 72 h. " 12/01/1986 - "Weanling male Sprague-Dawley rats were injected via the tail vein with methylazoxymethanol (MAM) acetate at a dose of 70 mg/kg body weight. " 04/01/1986 - "Methylazoxymethanol (MAM) acetate, at a weekly dose of 0.2 mg/10 g body weight, was given to germfree mice and to mice monocontaminated with either L. "
4.	Carcinogenesis 02/01/1984 - "Inhibition of intestinal tumorigenesis in methylazoxymethanol-treated rats by dietary restriction." 08/01/1986 - "The effect of cholecystectomy on colon carcinogenesis induced by methylazoxymethanol (MAM) acetate was examined in four groups of Syrian golden hamsters. " 01/01/1982 - "Congenital malformations of the central nervous system and transplacental carcinogenesis: modification of ethylnitrosourea-induced brain tumors in rats by pretreatment with methylazoxymethanol." 02/01/1991 - "The synergistic potential of 1-hydroxyanthraquinone (1-HA) on methylazoxymethanol (MAM) acetate-induced carcinogenesis was investigated in rats. " 01/01/1991 - "Effects of ethanol or saké on intestinal carcinogenesis by methylazoxymethanol (MAM) acetate were examined in two experiments. "
5.	Microcephaly 03/01/1990 - "Methylazoxymethanol-lesioned animals with mild cortical hypoplasia remained measurably hyperactive and may serve as a model for the study of neurotransmitter and neuropathologic abnormalities associated with hyperactivity in children with microcephaly." 01/26/1998 - "Injection of the antimitotic drug methylazoxymethanol (MAM) in the pregnant rat at E14 leads in the offsprings to a severe malformation with microcephaly and cortical heterotopiae in the white matter and in the CA1 field of the hippocampus. " 01/26/1998 - "Injection of the antimitotic drug methylazoxymethanol (MAM) in the pregnant rat at E14 leads in the offsprings to a severe malformation with microcephaly and cortical heterotopiae in the white matter and in the CA1 field of the hippocampus. " 01/01/1998 - "Abnormal development of serotonin nerve fibers in the visual cortex in rats with methylazoxymethanol-induced microcephaly." 01/01/1992 - "Developmental alteration of serotonin neurons in the raphe nucleus of rats with methylazoxymethanol-induced microcephaly."

Related Drugs and Biologics

1.	Carcinogens
2.	2-Acetylaminofluorene (2 Acetylaminofluorene)
3.	Azoxymethane
4.	Nitrosamines
5.	Methylcholanthrene
6.	Dimethylhydrazines
7.	Diethylnitrosamine (N-Nitrosodiethylamine)
8.	Aflatoxins
9.	anthracene
10.	Histones (Histone)

Related Therapies and Procedures

1.	Self Administration (Administration, Self)
2.	Intraperitoneal Injections
3.	Intravenous Injections
4.	Subcutaneous Injections
5.	Injections