hippuric acid

RN given refers to parent cpd; structure in Merck Index, 9th ed, #4591

Also Known As:

ammonium hippurate; benzamidoacetic acid; benzoylglycine; hippurate; hippuric acid, (14)C-labeled; hippuric acid, monoammonium salt; hippuric acid, monopotassium salt; hippuric acid, monosodium salt

Networked: 299 relevant articles (15 outcomes, 21 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Holmes, Elaine: 7 articles (01/2019 - 04/2008)
2.	Utzinger, Jürg: 5 articles (09/2011 - 04/2008)
3.	Hwang, Geum-Sook: 4 articles (01/2018 - 01/2010)
4.	Ryu, Do Hyun: 4 articles (01/2018 - 01/2010)
5.	Wang, Yulan: 4 articles (09/2011 - 04/2008)
6.	Cox, I Jane: 3 articles (01/2017 - 09/2010)
7.	Taylor-Robinson, Simon D: 3 articles (01/2017 - 09/2010)
8.	Li, Jia V: 3 articles (09/2011 - 04/2008)
9.	Saric, Jasmina: 3 articles (09/2011 - 04/2008)
10.	Singer, Burton H: 3 articles (05/2010 - 04/2008)

Related Diseases

1.	Body Weight (Weight, Body) 11/01/2004 - "Body weights were reduced in mice exposed to 2100 ppm and in rats and mice exposed to 4100 ppm. In rats, hippuric acid excretion was dose proportional indicating that absorption, metabolism, and excretion were not saturated. " 01/01/1980 - "m2 or 2.48 ml/min/100 g body weight) corresponds in its extent with the clearance after a single injection of unlabelled hippuric acid and is higher (20%) than the clearance after a single injection of 131I-hippuran. " 02/01/2018 - "Therefore, the relationships were investigated between renal energy, nitrogen (N) and hippuric acid excretion of four adult ponies (230-384 kg body weight (BW)) consuming diets based on fresh grass, grass silage, grass cobs (heat-dried, finely chopped, pressed grass), alfalfa hay, straw, extruded straw and soybean meal. " 02/01/1997 - "Benzoate metabolism was also studied in vivo by monitoring the urinary hippurate excretion after intraperitoneal administration of benzoate (100 micromol/100 g of body weight). " 01/01/1994 - "The influence of not occupational factors (smoking, alcohol, coffee, drugs, sport, sex, age and body weight) on hippuric acid excretion was analyzed in two groups of healthy male subjects. "
2.	Ischemia 05/01/1983 - "Furosemide prolonged the clearance of hippurate and increased kidney ischemia in alcohol intoxication. " 01/01/1987 - "The intravenous infusion of hum-SOD and bov-SOD, started concomitantly with the kidney reperfusion after a 60-min (or 30-min) period of ischemia, significantly improved the renal function (inulin and p-amino-hippuric acid clearance rates) as compared to the vehicle-treated control group. "
3.	Infections 11/22/2005 - "The initial studies that looked at the effects of cranberries on urine showed that the excretion of hippuric acid from the berries helped the urine to remain acidic, which could explain why they could be used to treat and prevent infection (Harkin, 2000). " 02/01/2021 - "Hippurate, a metabolite which concentration is intimately modulated by the gut microbiota, was found to be highly correlated to infection intensity. " 04/22/2008 - "Metabolic disturbance of gut microbiotal activity was associated with infection, as indicated by changes in the urinary concentrations of the microbial co-metabolites, including hippurate. " 01/01/2005 - "Neither hippurate-negative Brachyspira pilosicoli nor Brachyspira pilosicoli type strain caused diarrhoea in early-weaned pigs by experimental infection." 04/01/2008 - "pylori infection modifies the gut microbiota as highlighted by a range of microbial-related metabolites such as indoxyl sulfate and hippurate. "
4.	Hypertension (High Blood Pressure) 08/01/1991 - "The study was to test the hypothesis that patients with disturbance of renal hippurate transport (pathologic renogram) induced by exercise would have stabilized hypertension and would continue to be hypertensive after operation. " 08/01/1991 - "An exercise-mediated disturbance of renal hippurate transport was recently described, and has been implicated as having a role in nephrogenic fixed hypertension. " 08/01/1988 - "On follow-up examination a mean of over 14 months after angioplasty 51.7% of the patients had normal blood pressure or less pronounced hypertension, while in 60.9% the total hippuric acid clearance had increased." 02/01/1983 - "We investigated the influence that posture and exercise have on hippurate kinetics in patients with hypertension. " 07/01/1981 - "Hippurate function scintiscans were obtained in prone and standing positions in a group of 76 patients with concurrent hypertension and nephroptosis. "
5.	Urinary Tract Infections (Urinary Tract Infection) 11/01/1979 - "Methenamine mandelate and hippurate are effective in the prevention of recurrent urinary tract infections except in patients with Foley catheters or who require intermittent catheterization." 11/01/2016 - "No significant differences in prophylactic antibiotic treatment with nitrofurantoin and norfloxacin, trimethoprim, sulfamethoxazole/trimethoprim, methamine hippurate, estriol, or cefaclor were found in clinical or microbiological cure in adult nonpregnant women with recurrent urinary tract infections (9 randomized control trials, 673 patients, relative risk ratio, 1.06; 95% confidence interval, 0.89-1.27; I2, 65%; and 12 randomized control trials, 1063 patients, relative risk ratio, 1.06; 95% confidence interval, 0.90-1.26; I2, 76%, respectively). "

Related Drugs and Biologics

1.	Inulin
2.	Urea (Carbamide)
3.	Biomarkers (Surrogate Marker)
4.	Creatinine
5.	Succinic Acid (Succinate)
6.	Benzoic Acid (Potassium Benzoate)
7.	Pyruvic Acid (Pyruvate)
8.	Taurine
9.	Acetone
10.	Betaine (C.B.B.)

Related Therapies and Procedures

1.	Intravenous Infusions
2.	Catheters
3.	Therapeutics
4.	Renal Dialysis (Hemodialysis)
5.	Surgical Instruments (Clip)