HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

1,2-cyclohexanediamine (dach)

RN given refers to cpd without isomeric designation
Also Known As:
dach; 1,2-DACH; 1,2-cyclohexanediamine, (1R,2R)-; 1,2-cyclohexanediamine, (1R-trans)-; 1,2-cyclohexanediamine, (1S,2S)-; 1,2-cyclohexanediamine, (1S-trans)-; 1,2-cyclohexanediamine, (cis)-isomer; 1,2-cyclohexanediamine, (trans)-(R)-isomer; 1,2-cyclohexanediamine, (trans)-(S)-isomer; 1,2-cyclohexanediamine, (trans)-isomer; 1,2-diaminocyclohexane; 1,2-diaminocyclohexane, (+)-; 1,2-diaminocyclohexane, (-)-; 1,2-diaminocyclohexane, cis-; 1,2-diaminocyclohexane, trans-; cyclohexane-1,2-diamine; meso-1,2-diaminocyclohexane; trans-1,2-cyclohexanediamine; trans-1,2-diaminocyclohexane
Networked: 138 relevant articles (7 outcomes, 19 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Margiotta, Nicola: 5 articles (06/2022 - 04/2008)
2. Natile, Giovanni: 5 articles (06/2022 - 04/2008)
3. Cervelli, Manuela: 4 articles (01/2022 - 03/2016)
4. Marcoli, Manuela: 4 articles (01/2022 - 03/2016)
5. Mariottini, Paolo: 4 articles (01/2022 - 03/2016)
6. Wu, Kongming: 4 articles (01/2020 - 01/2015)
7. Ho, Yee-Ping: 4 articles (06/2014 - 03/2006)
8. Pang, Siu-Kwong: 4 articles (06/2014 - 03/2006)
9. Bednarski, Patrick J: 4 articles (08/2009 - 12/2004)
10. Hoeschele, James D: 3 articles (06/2022 - 08/2012)

Related Diseases

1. Neoplasms (Cancer)
2. Carcinoma (Carcinomatosis)
01/01/1997 - "Three human ovarian carcinoma cell lines (41 M, 41 McisR and SKOV-3) showed no (or inconsistent) chiral discrimination in their sensitivity to Pt(DACH) enantiomers, whereas two cell lines (CH-1 and CH-1cisR) showed modest enantiomeric selectivity favouring the R,R isomer (more active). "
01/01/2014 - "The most promising drug candidate, 4b (Pt(DACH)(mal)2), demonstrated low in vivo toxicity but profound anticancer activity against both the L1210 leukemia and CT-26 colon carcinoma models."
06/01/1995 - "At the cellular level, the dach carrier ligand appears to affect Pt accumulation in Pt resistant mouse L1210 cells, but has little effect on either Pt uptake or efflux in Pt-resistant human ovarian and colon carcinoma cell lines. "
01/01/1998 - "Based on consideration of both in vitro cytotoxicity in human colon carcinoma cells (HT-29) and concentrations following oxaliplatin administration in vivo, our data suggest that the efficacy of oxaliplatin is primarily determined by the plasma levels of the parent drug, with the biotransformation products Pt(dach)Cl2, Pt(dach)(H2O)Cl, and Pt(dach)(H2O)2 making only minor contributions. "
10/14/2020 - "In the present study, cytotoxic effects of recently synthesized ruthenium(II) terpyridine complexes [Ru(Cl-tpy)(en)Cl][Cl] (en = ethylenediamine, tpy = terpyridine, Ru-1) and [Ru(Cl-tpy)(dach)Cl][Cl] (dach = 1,2-diaminocyclohexane, Ru-2) towards human and murine colon carcinoma cells were tested in vitro and in vivo and compared with oxaliplatin, the most commonly used chemotherapeutic agent against colorectal carcinoma. "
3. Urinary Bladder Neoplasms (Bladder Cancer)
4. Colorectal Neoplasms (Colorectal Cancer)
5. Leukemia L1210

Related Drugs and Biologics

1. Platinum
2. 1,2-cyclohexanediamine (dach)
3. Oxaliplatin (Eloxatin)
4. Cisplatin (Platino)
5. Ligands
6. DNA (Deoxyribonucleic Acid)
7. DNA Adducts
8. tesmilifene (DPPE)
9. dichloro-1,2-diaminocyclohexane platinum complex (Pt 155)
10. Nitrogen

Related Therapies and Procedures

1. Drug Therapy (Chemotherapy)
2. Therapeutics
3. Aftercare (After-Treatment)
4. Hyperthermic Intraperitoneal Chemotherapy