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beta-D-galactoside alpha 2-6-sialyltransferase

catalyzes the reaction of CMP-N-acetylneuraminate & galactosylglycoprotein to yield CMP & N-acetylneuraminylgalactosylglycoprotein; CD75 and CD75w antigen were removed as SYs - it is not equivalent to the enzyme - see Cell 1992 Mar 20;68(6):1003
Also Known As:
CMP-N-acetylneuraminate-D-galactosyl-glycoprotein N-acetylneuraminyltransferase; CMP-N-acetylneuraminate-beta-galactoside alpha-2,6-sialyltransferase; CMP-N-acetylneuraminate-galactosylglycoprotein sialyltransferase; CMP-N-acetylneuraminic acid-lactose sialytransferase; CMP-NeuAc-galactoside (alpha 2-6)-sialyltransferase; CMP-acetylneuraminate galactoside (alpha 2-6)-sialyltransferase; CMP-sialic acid-N-acetyllactosaminide alpha (2-6)-sialyltransferase; Gal-1-4-GlcNAc alpha(2-6)-sialyltransferase; Gal-GlcNAc(2-6)-sialyltransferase; HST6N-1; SIAT-1; ST6(N); ST6Gal I; ST6Gal-1; alpha 2-6-sialyltransferase; alpha-2,8-sialyltransferase; alpha2,6(N) sialyltransferase; alpha6-sialyltransferase; beta-galactoside alpha2,6-sialyltransferase; beta-galactosyl(1-4)N-acetylglucosaminide alpha(2-6)-sialyltransferase; hST6Gal I
Networked: 65 relevant articles (0 outcomes, 15 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Li, Hong: 4 articles (03/2007 - 01/2007)
2. Lee, Minyoung: 3 articles (01/2012 - 08/2008)
3. Lee, Yun-Sil: 3 articles (01/2012 - 08/2008)
4. Taniguchi, Naoyuki: 3 articles (09/2010 - 03/2005)
5. Wang, Peng-Hui: 3 articles (04/2007 - 07/2002)
6. Yuan, Chiou-Chung: 3 articles (04/2007 - 07/2002)
7. Chiricolo, Mariella: 3 articles (02/2006 - 01/2004)
8. Dall'Olio, Fabio: 3 articles (02/2006 - 01/2004)
9. Vallejo-Ruiz, Verónica: 2 articles (06/2012 - 03/2009)
10. Reyes-Leyva, Julio: 2 articles (06/2012 - 03/2009)

Related Diseases

1. Carcinoma (Carcinomatosis)
2. Colonic Neoplasms (Colon Cancer)
3. Squamous Cell Carcinoma (Epidermoid Carcinoma)
06/01/2003 - "Enhanced expression of alpha 2,6-sialyltransferase ST6Gal I in cervical squamous cell carcinoma."
03/01/2009 - "Increased mRNA expression of STs (ST6Gal I, ST3Gal III) has been detected in invasive cervical squamous cell carcinoma. "
10/01/2001 - "ST6Gal I expression was enhanced in squamous cell carcinoma of the cervix (P = 0.026, Mann-Whitney U test), but mRNA expression from the other three STs (ST3Gal I, ST3Gal III, and ST3Gal IV) was significantly down-expressed in squamous cell carcinoma of the cervix compared to the normal cervix (P = 0.003, P < 0.001, and P = 0.001, respectively). "
01/01/2013 - "In summary, our results showed that the high expression of ST3Gal I and ST6Gal I, in skin tumors, is associated with tumors with greater potential for invasion and metastasis, as in the case of squamous cell carcinoma, and this may be related to their behavior."
01/01/2013 - "The expression of ST3Gal I was observed in actinic keratosis (53%), keratoacanthoma (78%), squamous cell carcinoma (73%) and basal cell carcinoma (32%) with statistic differences between basal cell carcinoma and keratoacanthoma (P=0.0239) and basal cell carcinoma and squamous cell carcinoma (P=0.0096); for ST6Gal I, cytoplasmic expression was noted in actinic keratosis (40%), heterogeneous and cytoplasmic expression was noted in keratoacanthoma (67%), squamous cell carcinoma (41%) and basal cell carcinoma (7%) with statistic differences between basal cell carcinoma and squamous cell carcinoma (P=0.0061) and basal cell carcinoma and keratoacanthoma (P=0.0008). "
4. Colorectal Neoplasms (Colorectal Cancer)
5. Neoplasms (Cancer)

Related Drugs and Biologics

1. beta-galactoside alpha-2,3-sialyltransferase
2. Small Interfering RNA (siRNA)
3. Messenger RNA (mRNA)
4. Sialyltransferases
5. beta-D-galactoside alpha 2-6-sialyltransferase
6. N-Acetylneuraminic Acid (Sialic Acid)
7. Complementary DNA (cDNA)
8. Antisense Oligonucleotides
9. RNA (Ribonucleic Acid)
10. Cytidine Monophosphate (CMP)

Related Therapies and Procedures

1. Subcutaneous Injections