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indole

RN given refers to parent cpd; structure in Merck Index, 9th ed, #4840
Also Known As:
indole hydrochloride; indole, 14C-labeled
Networked: 728 relevant articles (37 outcomes, 74 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Firestone, Gary L: 12 articles (11/2013 - 08/2002)
2. Bjeldanes, Leonard F: 12 articles (11/2013 - 08/2002)
3. Louis, Elan D: 10 articles (09/2014 - 01/2008)
4. Zheng, Wei: 9 articles (09/2014 - 03/2008)
5. Factor-Litvak, Pam: 9 articles (09/2014 - 01/2008)
6. Jiang, Wendy: 8 articles (09/2014 - 03/2008)
7. Reiter, Russel J: 7 articles (04/2010 - 10/2003)
8. Preobrazhenskaya, Maria N: 5 articles (08/2010 - 03/2005)
9. Yao, Ching-Fa: 4 articles (11/2015 - 08/2008)
10. Singh, Palwinder: 4 articles (03/2014 - 03/2007)

Related Diseases

1. Neoplasms (Cancer)
2. Infection
3. Ischemia
4. Urinary Tract Infections (Urinary Tract Infection)
5. Seizures (Seizure)
09/24/1998 - "Affinity was restricted to the derivatives unsubstituted in the 5 position of the indole nucleus (1, 6, 9, 12, 15, 18, 23, and 26), with Ki values ranging from 510 to 11 nM. The most active compounds (6, 9, 23, and 29) proved to be effective in antagonizing pentylenetetrazole-induced seizures. "
03/14/1997 - "This indole derivative inhibited convulsions induced by NMDA in mice, when administered by both iv and po routes (ED50 = 0.06 and 6 mg/kg, respectively). "
10/16/1998 - "The 5-HT2C/2B receptor-preferring agonist 1-(m-chlorophenyl)-piperazine (mCPP; 2.5-7 mg/kg i.p.) weakly elevated seizure threshold in the mouse (but not the rat) electroshock test and also provided appreciable protection against pentylenetetrazol-induced myoclonic and/or tonic seizures in mice and rats, an action that was inhibited by the 5-HT2C/2B receptor antagonist 5-methyl-1-(3-pyridylcarbomoyl)-1,2,3,5-tetrahydropyrrolo[2, 3-f]indole (SB-206553; 10-20 mg/kg p.o.). "
03/14/1997 - "A series of indole-2-carboxylates bearing suitable chains at the C-3 position of the indole nucleus was synthesized and evaluated in terms of in vitro affinity using [3H]glycine binding assay and in vivo potency by inhibition of convulsions induced by N-methyl-D-aspartate (NMDA) in mice. "
01/01/1998 - "In chronically vehicle-treated mice, the potent and selective MDR agonist FGIN-1-27 (N,N-di-n-hexyl 2-(4-fluorophenyl)indole-3-acetamide: 30 microg/mouse, i.c.v.) markedly increased the threshold for pentylenetetrazole (PTZ)-induced seizure. "

Related Drugs and Biologics

1. Melatonin
2. Hormones
3. Pentylenetetrazole (Metrazol)
4. Neurotransmitter Agents (Neurotransmitter)
5. Interleukin-2 (IL2)
6. Amines
7. N-Methylaspartate (NMDA)
8. Carbon
9. pyrimidine
10. Carboxylic Acids

Related Therapies and Procedures

1. Immunotherapy
2. Heterologous Transplantation (Xenotransplantation)
3. Lasers (Laser)
4. Electrocoagulation (Electrocautery)
5. Drug Therapy (Chemotherapy)