|1.||Firestone, Gary L: 12 articles (11/2013 - 08/2002)|
|2.||Bjeldanes, Leonard F: 12 articles (11/2013 - 08/2002)|
|3.||Louis, Elan D: 10 articles (09/2014 - 01/2008)|
|4.||Zheng, Wei: 9 articles (09/2014 - 03/2008)|
|5.||Factor-Litvak, Pam: 9 articles (09/2014 - 01/2008)|
|6.||Jiang, Wendy: 8 articles (09/2014 - 03/2008)|
|7.||Reiter, Russel J: 7 articles (04/2010 - 10/2003)|
|8.||Preobrazhenskaya, Maria N: 5 articles (08/2010 - 03/2005)|
|9.||Yao, Ching-Fa: 4 articles (11/2015 - 08/2008)|
|10.||Singh, Palwinder: 4 articles (03/2014 - 03/2007)|
12/22/2005 - "Indole alkaloid marine natural products: an established source of cancer drug leads with considerable promise for the control of parasitic, neurological and other diseases."
07/01/2006 - "We therefore tested the hypothesis that 5-methoxy-1,2-dimethyl-3-[(4-nitrophenoxy)methyl]indole-4,7-dione (ES936), a specific mechanism-based inhibitor of NQO1, would be an effective agent for the treatment of pancreatic tumors. "
09/27/2013 - "The combination of these results provides evidence that the indole-based phosphate prodrug 33 (OXi8007) functions as a vascular disrupting agent that may prove useful for the treatment of cancer."
06/15/2008 - "We are now employing 2.30a as a new lead compound in our efforts to discover improved indole-based cancer chemotherapeutics."
03/03/2014 - "Structural optimization of indole based compounds for highly promising anti-cancer activities: structure activity relationship studies and identification of lead molecules."
01/01/2015 - "Melanization occurs both in vitro, in the presence of catecholamine and indole compounds, and in vivo during the infection. "
09/01/2014 - "In addition to its role in promoting sleep and circadian rhythms regulation, it has important immunomodulatory, antioxidant, and neuroprotective effects suggesting that this indole must be considered as a therapeutic alternative against infections. "
05/01/2014 - "A dihydro-pyrido-indole potently inhibits HSV-1 infection by interfering the viral immediate early transcriptional events."
09/01/2012 - "albicans infection (P = 0.0188 and P < 0.0001 for indole and IAN, respectively, compared to worms exposed to C. "
11/05/2007 - "Indole derivatives (1H-indole, 4-methylindole and 1-ethylindole) were suggested to be the key factors contributing to the pepper infection caused by Colletotrichum spp. We conclude that SFSI in combination with GC is a suitable approach for distinguishing between healthy and diseased peppers by the investigation of their volatile compounds. "
09/23/2010 - "Synthesis and characterization of novel indole derivatives reveal improved therapeutic agents for treatment of ischemia/reperfusion (I/R) injury."
01/01/2015 - "Evaluation of tumor ischemia in response to an indole-based vascular disrupting agent using BLI and (19)F MRI."
01/01/1999 - "The paper presents an overview of indole derived compounds in which protective action has been demonstrated in the NS in situations in which ROS are excessively generated, such as chemically induced oxidative stress, hypoxia/reoxygenation, ischemia/reperfusion. "
10/25/2004 - "The protective effects of the Na+-H+ exchange (NHE) inhibitors SM-198110 (2-[[(aminoiminomethyl) amino] carbonyl]-4-chloro-1H-indole-1-propanesulfonic acid monohydrate) and SM-197378 (N-(aminoiminomethyl)-1-methyl-7-(sulfooxy)-4-(trifluoromethyl)-1H-indole-2-carboxamide monohydrate) were investigated in perfused Langendorff guinea-pig hearts subjected to ischemia (40 min) and reperfusion (40 min). "
06/01/1995 - "In the present study, a newly synthetized lipid peroxidation inhibitor H290/51 [cis-7methyl-9-methoxy-5,5a,b,10b- tetrahydroindeno(2,1-6 indole)] was evaluated for its effects on myocardial functional recovery during reperfusion after 30-min global ischemia in isolated cold-arrested rat hearts. "
|4.||Urinary Tract Infections (Urinary Tract Infection)
04/30/1982 - "The incidence of nosocomial urinary tract infections and the species of organisms involved have been favourably influenced by a new antibiotic regimen, as well as improved hygienic measures in the Urological Department of the Allgemeine Poliklinik der Stadt Wien (reduction in the mean postoperative infection rate following adenomectomy from 90 to 40%; decrease in typical hospital organisms such as Pseudomonas aeruginosa from over 50 to below 10% and in indole-positive Proteus strains from 25 to below 5%)."
01/01/1979 - "Ten patients with spinal cord injuries who had urinary tract infections due to Serratia or indole-positive Proteus were treated, and all 10 were cured. "
05/28/1976 - "coli and Citrobacter, 45% of enterobacter, 40% of Proteus mirabilis and enterococci, 35% of the indole-positive Proteus strains and 30% of Pseudomonas aeruginosa would have been successfully attacked by Terizidon in the case or urinary tract infections. "
12/01/1994 - "Rapid identification of micro-organisms from urinary tract infections by beta-glucuronidase, phenylalanine deaminase, cytochrome oxidase and indole tests on isolation media."
03/01/2008 - "Tryptophan is converted to indole and indigo-producing bacteria have indoxyl phosphatase or sulfatase that can produce indigo (blue) and/or indirubin (red) in patients with urinary tract infection. "
09/24/1998 - "Affinity was restricted to the derivatives unsubstituted in the 5 position of the indole nucleus (1, 6, 9, 12, 15, 18, 23, and 26), with Ki values ranging from 510 to 11 nM. The most active compounds (6, 9, 23, and 29) proved to be effective in antagonizing pentylenetetrazole-induced seizures. "
03/14/1997 - "This indole derivative inhibited convulsions induced by NMDA in mice, when administered by both iv and po routes (ED50 = 0.06 and 6 mg/kg, respectively). "
10/16/1998 - "The 5-HT2C/2B receptor-preferring agonist 1-(m-chlorophenyl)-piperazine (mCPP; 2.5-7 mg/kg i.p.) weakly elevated seizure threshold in the mouse (but not the rat) electroshock test and also provided appreciable protection against pentylenetetrazol-induced myoclonic and/or tonic seizures in mice and rats, an action that was inhibited by the 5-HT2C/2B receptor antagonist 5-methyl-1-(3-pyridylcarbomoyl)-1,2,3,5-tetrahydropyrrolo[2, 3-f]indole (SB-206553; 10-20 mg/kg p.o.). "
03/14/1997 - "A series of indole-2-carboxylates bearing suitable chains at the C-3 position of the indole nucleus was synthesized and evaluated in terms of in vitro affinity using [3H]glycine binding assay and in vivo potency by inhibition of convulsions induced by N-methyl-D-aspartate (NMDA) in mice. "
01/01/1998 - "In chronically vehicle-treated mice, the potent and selective MDR agonist FGIN-1-27 (N,N-di-n-hexyl 2-(4-fluorophenyl)indole-3-acetamide: 30 microg/mouse, i.c.v.) markedly increased the threshold for pentylenetetrazole (PTZ)-induced seizure. "
|4.||Neurotransmitter Agents (Neurotransmitter)
|2.||Heterologous Transplantation (Xenotransplantation)
|5.||Drug Therapy (Chemotherapy)