|1.||Odin, Elisabeth: 3 articles (10/2015 - 04/2013)|
|2.||Iacopetta, Barry: 3 articles (12/2008 - 12/2003)|
|3.||Kawakami, Kazuyuki: 3 articles (12/2008 - 12/2003)|
|4.||Derwinger, Kristoffer: 2 articles (10/2015 - 12/2014)|
|5.||Carlsson, Göran: 2 articles (10/2015 - 04/2013)|
|6.||Gustavsson, Bengt: 2 articles (10/2015 - 04/2013)|
|7.||Wettergren, Yvonne: 2 articles (12/2014 - 04/2013)|
|8.||Kabra, Madhulika: 2 articles (10/2008 - 03/2008)|
|9.||Moore, James: 2 articles (11/2006 - 12/2003)|
|10.||Ruszkiewicz, Andrew: 2 articles (11/2006 - 12/2003)|
|1.||Colorectal Neoplasms (Colorectal Cancer)
07/01/2012 - "Colorectal mucosa from colorectal cancer subjects had lower 5-methyltetrahydrofolate and higher tetrahydrofolate and formyltetrahydrofolate levels than blood from the same individual. "
12/01/2003 - "The concentrations of two major intracellular FIs, 5,10-methylenetetrahydrofolate and tetrahydrofolate (FH4), were measured in 103 surgically resected colorectal cancers. "
01/01/1993 - "The combination of leucovorin [(6d,l)-5-formyl-tetrahydrofolate] and 5-fluorouracil (5-FU) has increased efficacy compared to 5-FU alone as treatment of advanced colorectal cancer. "
10/01/2015 - "Modufolin® ([6R]-5,10-methylene tetrahydrofolate; [6R]-MTHF) is an endogenous biomodulator that is being developed as an alternative to leucovorin, a folate prodrug used in the treatment of colorectal cancer. "
12/01/2014 - "The aim was to determine the levels of tetrahydrofolate (THF), 5,10-methylenetetrahydrofolate (methyleneTHF), and 5-methyltetrahydrofolate (methylTHF) in tumour and mucosa of colorectal cancer patients who received different dosages of leucovorin intravenously at time of surgery. "
10/01/1980 - "Treatment of monkeys with repetitive doses of either sodium folate (48, 24, 12, and 4 hr prior to methanol) or 5-formyl tetrahydrofolic acid (2 mg/kg at 0, 4, 8, 12, and 18 hr after methanol) resulted in a marked decrease in the levels of blood formate and an absence of both metabolic acidosis and depletion of blood bicarbonate following methanol administration. "
04/03/1992 - "The resulting tetrahydrofolate analogues could serve as cofactors for the thymidylate synthase cycle of murine leukemia L1210 cells in situ. "
03/01/1989 - "These studies demonstrate very weak inhibition of L1210 leukemia cell growth and purine, pyrimidine and tetrahydrofolate synthesis by the polyglutamyl congeners of 7-OH-MTX. "
08/08/1991 - "Failure to interconvert tetrahydrofolate cofactors to dihydrofolate in mitochondria of L1210 leukemia cells treated with trimetrexate."
03/25/1991 - "Rate and extent of interconversion of tetrahydrofolate cofactors to dihydrofolate after cessation of dihydrofolate reductase activity in stationary versus log phase L1210 leukemia cells."
06/15/1990 - "In L1210 leukemia cells grown in tritiated folic acid (1 microM), most of the endogenous radiolabeled folates were present as formyl-substituted tetrahydrofolates (60-73%, including 10- and 5-formyl and 5,10-methenyl tetrahydrofolate), with lower levels of tetrahydrofolate (including 5,10-methylene tetrahydrofolate), 5-methyl tetrahydrofolate, and non-metabolized folic acid. "
11/01/1983 - "These results indicate that hepatic methionine synthetase is important in the regulation of tetrahydrofolate-dependent metabolism in the monkey and that the generation of tetrahydrofolate by this enzyme is a major factor in determining the sensitivity of a species to methanol poisoning."
10/27/1977 - "Poisoning with methanol is to be treated with ethanol trisbuffer and tetrahydrofolic acid (Folsan). "
05/01/1987 - "Since the rate of formate oxidation is related to hepatic tetrahydrofolate (H4folate) content and the activities of folate-dependent enzymes, studies were designed to determine hepatic concentrations of H4folate and activities of folate-dependent enzymes of human liver and livers of species considered insensitive to methanol poisoning. "
04/01/1981 - "These studies support the concept of a key role of methionine synthetase in supplying the tetrahydrofolate required for the folate-dependent oxidation of formate to carbon dioxide as well as the importance of this pathway in determining the sensitivity of a species to methanol poisoning."
01/07/2014 - "Inhibition of the biosynthesis of tetrahydrofolate (THF) has long been a focus in the treatment of both cancer and infectious diseases. "
12/01/2008 - "Elevated concentrations of 5-10-methylene tetrahydrofolate (CH(2)FH(4)) occur in CIMP+ tumors and are probably due to low expression levels for gamma-glutamyl hydrolase (GGH). "
03/01/1993 - "Leucovorin, given usually by i.v. injection or orally changes to 5, 10-methylene tetrahydrofolate in tumor as well as normal cells. "
07/01/1992 - "Leucovorin (LV), given intravenously the orally becomes 5, 10-methylene tetrahydrofolate in both cancer and normal cells. "
01/01/1998 - "The in vitro stability and plasma pharmacokinetics of 5,10-methylenetetrahydrofolic acid (CH2FH4), tetrahydrofolic acid (FH4), 5-methyltetrahydrofolic acid (CH3FH4), and 5-formyltetrahydrofolic acid (5-CHOFH4) were studied in view of their potential usefulness in cancer chemotherapy. "
|1.||Folic Acid (Vitamin M)
|3.||formic acid (formate)
|4.||Leucovorin (Folinic Acid)
|4.||Drug Therapy (Chemotherapy)