anthrax toxin (anthrax lethal factor)

133  relevant articles (11 outcomes, 8 trials/studies) found for this Bio-Agent

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Bio-Agent Context: Research Results

Experts

1.	Leppla, Stephen H: 6 articles (06/2008 - 02/2003)
2.	Liu, Shihui: 5 articles (04/2007 - 02/2003)
3.	Collier, R John: 4 articles (10/2007 - 05/2002)
4.	Frankel, Arthur E: 3 articles (06/2008 - 10/2006)
5.	Bugge, Thomas H: 3 articles (04/2007 - 06/2005)
6.	Leppla, S H: 3 articles (05/2001 - 11/2000)
7.	Duesbery, Nicholas S: 2 articles (06/2008 - 03/2002)
8.	Li, Han: 2 articles (11/2007 - 10/2004)
9.	Quinn, Conrad P: 2 articles (11/2007 - 10/2004)
10.	Flick-Smith, Helen C: 2 articles (11/2007 - 04/2002)

Related Diseases

1.	Anthrax 05/28/2004 - "The high affinity of the VWA domain for PA supports its potency in neutralizing anthrax toxin, demonstrating its potential utility as a novel therapeutic for anthrax." 02/01/1992 - "The protective efficacy of immunization against anthrax with Bacillus anthracis protective antigen (PA) combined with different adjuvants was tested in Hartley guinea pigs and CBA/J and A/J mice. " 12/01/1995 - "The efficacy of several human anthrax vaccine candidates comprised of different adjuvants together with Bacillus anthracis protective antigen (PA) was evaluated in guinea pigs challenged by an aerosol of virulent B. " 11/01/1994 - "Bacillus anthracis protective antigen, expressed in Salmonella typhimurium SL 3261, affords protection against anthrax spore challenge." 02/26/2009 - "Anthrax lethal factor (LF) is a critical virulence factor in the pathogenesis of anthrax. " Order ALL the reference details at left...
2.	Infection 09/01/2006 - "Anthrax toxin and capsule, determinants for successful infection by Bacillus anthracis, are encoded on the virulence plasmids pXO1 and pXO2, respectively. " 06/01/2006 - "Although the action of the tripartite anthrax toxin has been extensively studied in vitro, relatively little is known about the presence of toxins during an infection in vivo. " 06/01/2006 - "Several strategies that target anthrax toxin are being developed as therapies for infection by Bacillus anthracis. " 04/01/2006 - "The model is inspired by recent experimental work on the blocking of the PA(63) channel, involved in the anthrax toxin infection, by a highly charged drug [Karginov PNAS 102, 15075 (2005)]. " 02/01/2004 - "The understanding of the molecular events induced by anthrax toxin in different target cells at each stage of infection will aid in deciphering the pathogenesis of this bacterium and developing therapies." Order ALL the reference details at left...
3.	Neoplasms (Cancer) 10/17/2007 - "Tumor endothelial marker 8 (TEM8) was discovered as a cell membrane protein that is predominantly expressed in tumor endothelium and identified as a receptor for anthrax toxin. " 11/25/2005 - "The pH requirement for pore formation was receptor-specific as membrane insertion occurs at significantly different pH values when measured in cells specifically expressing tumor endothelial marker 8 (TEM8) or capillary morphogenesis protein 2 (CMG2), the two known cellular receptors for anthrax toxin. " 06/01/2005 - "Intermolecular complementation achieves high-specificity tumor targeting by anthrax toxin." 02/01/2004 - "Tumor endothelial marker (TEM)8 was uncovered as a gene expressed predominantly in tumor endothelium, and its protein product was recently identified as the receptor for anthrax toxin. " 02/14/2003 - "Cell surface tumor endothelium marker 8 cytoplasmic tail-independent anthrax toxin binding, proteolytic processing, oligomer formation, and internalization." Order ALL the reference details at left...
4.	Poisoning 08/07/2009 - "To our knowledge, this is the first report to illustrate that an anti-CMG2 antibody could inhibit the PA-CMG2 interaction and therefore interfere with the intoxication of anthrax toxin." 01/01/2003 - "Neutralizing monoclonal antibody against anthrax lethal factor inhibits intoxication in a mouse model." 01/01/2003 - "anthracis, we will focus on the latest findings that concern two aspects of anthrax toxin research: the environmental signals and the molecular mechanisms that regulate toxin synthesis, and the mechanisms of intoxication. " 03/01/1989 - "Anthrax toxin introduced subcutaneously into white rats Fisher-344 caused specific intoxication accompanied by characteristic pathomorphological changes and, when studied by the immunoperoxidase method in histological sections, could be detected in the blood stream (in plasma) and in the cytoplasm of macrophages (in the lungs and the spleen). " 01/01/2008 - "Previous studies showed that LRP6 was important for efficient intoxication of human M2182 prostate carcinoma cells but other studies performed with cells from gene-knockout mice demonstrated no role for either LRP6 or the related LRP5 protein in anthrax toxin entry. " Order ALL the reference details at left...
5.	Liver Failure 09/01/2003 - "A comprehensive study of the effects of anthrax toxin in mice demonstrates that toxin-induced death is mediated not by cytokine release, as previously thought, but by hypoxia-induced liver failure. " Order ALL the reference details at left...

Related Drugs and Biologics

1.	Antigens
2.	Antibodies
3.	anthrax toxin (anthrax lethal factor)
4.	edema factor
5.	Vaccines
6.	A-Form DNA (A-DNA)
7.	Anthrax Vaccines
8.	Anti-Bacterial Agents (Antibiotics)
9.	Matrix Metalloproteinases
10.	Glutamic Acid (Glutamate)

Related Therapies and Procedures

1.	Oral Administration
2.	Therapeutics
3.	Microspheres (Microsphere)
4.	Immunotherapy