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anthrax toxin (anthrax lethal factor)

consists of 3 separate proteins: PA (protective antigen/factor), EF (edema factor) & LF (lethal factor); these three are nontoxic proteins that associate in binary or ternary combinations to form toxic complexes at the surface of mammalian cells; Bacillus anthracis calmodulin-dependent adenylate cyclase is component of EF protein, is a zinc-dependent metalloprotease; PA63 is a proteolytic fragment of PA83
Also Known As:
anthrax lethal factor; 63 kDa anthrax protective antigen, Bacillus anthracis; 83 kDa anthrax protective antigen, Bacillus anthracis; Bacillus anthracis calmodulin-dependent adenylate cyclase; Bacillus anthracis, protective antigen; LF protein, Bacillus anthracis; LeTx toxin, B anthracis; PA antigen, Bacillus anthracis; PA63 protective antigen, Bacillus anthracis; PA63 protein, Bacillus anthracis; PA83 protective antigen, Bacillus anthracis; anthrax edema factor; anthrax protective antigen; anthrax toxin EF; anthrax toxin LF; anthrax toxin PA; anthrax toxins translocating protein, Bacillus anthracis; cya protein, Bacillus anthracis; edema factor exotoxin; edema factor, Bacillus anthracis; edema factor, anthrax toxin; edema toxin, Bacillus anthracis; lef protein, Bacillus anthracis; lethal factor, anthrax; lethal toxin, Bacillus anthracis; pag protein, Bacillus anthracis; pagA protein, Bacillus anthracis
Networked: 233 relevant articles (18 outcomes, 15 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Leppla, Stephen H: 29 articles (10/2015 - 02/2002)
2. Liu, Shihui: 16 articles (10/2015 - 02/2002)
3. Moayeri, Mahtab: 12 articles (03/2015 - 02/2002)
4. Collier, R John: 11 articles (06/2013 - 01/2002)
5. Quinn, Conrad P: 7 articles (05/2015 - 05/2006)
6. Chen, Wei: 7 articles (05/2015 - 03/2006)
7. Crown, Devorah: 7 articles (03/2015 - 01/2008)
8. Duesbery, Nicholas S: 6 articles (01/2011 - 03/2002)
9. Frankel, Arthur E: 6 articles (06/2008 - 08/2002)
10. Young, John A T: 6 articles (01/2008 - 02/2003)

Related Diseases

1. Anthrax
2. Infection
3. Neoplasms (Cancer)
4. Human Influenza (Influenza)
5. Liver Failure

Related Drugs and Biologics

1. Antigens
2. Neutralizing Antibodies
3. anthrax toxin (anthrax lethal factor)
4. edema factor
5. Vaccines
6. Antibodies
7. Exotoxins
8. Peptides
9. Immunoglobulin G (IgG)
10. Anthrax Vaccines

Related Therapies and Procedures

1. Oral Administration
2. Therapeutics
3. Microspheres (Microsphere)
4. Immunotherapy