|1.||Holler, Eggehard: 6 articles (12/2013 - 03/2006)|
|2.||Black, Keith L: 6 articles (12/2013 - 03/2006)|
|3.||Ljubimova, Julia Y: 6 articles (12/2013 - 03/2006)|
|4.||Ding, Hui: 5 articles (12/2013 - 10/2007)|
|5.||Patil, Rameshwar: 5 articles (12/2013 - 10/2007)|
|6.||Inoue, Satoshi: 4 articles (12/2013 - 10/2010)|
|7.||Konda, Bindu: 4 articles (12/2013 - 10/2010)|
|8.||Brindle, Kevin M: 4 articles (02/2012 - 11/2009)|
|9.||Wawrowsky, Kolja A: 4 articles (11/2010 - 03/2006)|
|10.||Zhao, Ting: 3 articles (11/2015 - 07/2015)|
02/01/2014 - "Healthy cells are impermeable to fumarate, so conversion of this metabolite to malate as detected by (13)C-magnetic resonance spectroscopy (MRS) has been suggested as one marker for cell death and treatment response in tumors. "
11/24/2009 - "Therefore, the formation of hyperpolarized (13)C-labeled malate from [1,4-(13)C(2)]fumarate appears to be a sensitive marker of tumor cell death in vivo and could be used to detect the early response of tumors to treatment. "
02/15/2012 - "Despite the minimal response of these tumors to treatment, with only a minor increase in necrosis observed histologically, production of [1,4-(13)C(2)]malate from hyperpolarized [1,4-(13)C(2)]fumarate in therapy-resistant tumors also increased. "
02/15/2012 - "Production of [1,4-(13)C(2)]malate from hyperpolarized [1,4-(13)C(2)]fumarate increased in parallel with tumor cell necrosis, preceding any change in tumor ADC. "
11/24/2009 - "We have used this method to image the conversion of fumarate to malate in a murine lymphoma tumor in vivo after i.v. injection of hyperpolarized [1,4-(13)C(2)]fumarate. "
12/01/2014 - "The aim of this study was to evaluate the clinical efficacy of a topical sialogogue spray containing 1% malic acid for elderly people affected by xerostomia. "
12/01/2014 - "A topical sialogogue spray containing 1% malic acid improved xerostomia in an elderly population and increased unstimulated and stimulated salivary flows rates."
12/01/2014 - "Evaluation of the efficacy of a topical sialogogue spray containing malic acid 1% in elderly people with xerostomia: a double-blind, randomized clinical trial."
01/01/2013 - "Malic acid 1% spray improved antihypertensive-induced xerostomia and stimulated the production of saliva."
12/01/2014 - "Forty-one individuals (mean age: 78.7 years) with xerostomia were divided into two groups: for the first 'intervention group' (21 subjects) a topical sialogogue spray (1% malic acid) was applied, while for the second 'control group' (20 subjects), a placebo spray was applied; for both groups, the sprays were applied on demand during 2 weeks. "
07/01/1972 - "[Study of malic acid and malate dehydrogenase cytochemically detectable during human leukemia]."
11/01/1986 - "Oxidation of reduced cytosolic nicotinamide adenine dinucleotide by the malate-aspartate shuttle in the K-562 human leukemia cell line."
09/01/1985 - "A selected set of 14 V(V) complexes was tested for toxicity and antitumor activity against L1210 murine leukemia, to examine the biological properties of peroxoheteroligand vanadates(V) of the formula (NH4)4[O(VO(O2)2)2], M3I[VO(O2)2C2O4], and MI[VO(O2)L], L = malate, citrate, iminodiacetate, nitrilotriacetate, and EDTA. "
05/01/2006 - "The isotopomer analysis of the lactate, alanine, glutamate, proline, serine, glycine, malate and ribose-5-phosphate moiety of nucleotides has allowed original integrated information regarding the pentose phosphate pathway, TCA cycle, and amino acid metabolism in proliferating human leukemia T cells to be obtained. "
03/01/2008 - "Since clinical trials with amonafide, a unique ATP-independent Topo II inhibitor, in combination with cytarabine, have shown significant efficacy for remission induction in patients with sAML, we compared the cytotoxic effect of amonafide (amonafide l-malate, Xanafide) to the classical Topo II inhibitors (daunorubicin, doxorubicin, idarubicin, etoposide, and mitoxantrone) in K562 leukemia cells and in the MDR subline, K562/DOX. "
04/01/1999 - "Collectively, these results suggest that feeding DL-malate to cattle consuming high-grain diets alleviates subclinical acidosis, and it improved animal performance in two finishing studies."
12/01/1998 - "These results suggest that the incorporation of forage varieties that are high in malate may include malate economically into the diet and reduce losses associated with ruminal acidosis."
01/01/1980 - "The malate/2-oxoglutarate transporter in mitochondria from rat kidney cortex: increased acitivity in metabolic acidosis."
01/01/1978 - "The phosphate concentration required for half-maximal rates of malate exit from renal mitochondria of normal rats was 1.0 mM. This value was not decreased in renal cortex mitochondria from rats with chronic metabolic acidosis. "
09/01/2011 - "acetate, lactate or malate) as bicarbonate precursors to prevent hyperchloraemic acidosis. "
|5.||Myocardial Ischemia (Ischemic Heart Diseases)
09/21/2008 - "Role of the malate-aspartate shuttle on the metabolic response to myocardial ischemia."
05/01/1986 - "The experiments on cats under the conditions of acute myocardial ischemia showed that malate (20 and 100 mg/kg) and NAD (0.2 and 2 mg/kg) are able of increasing the coronary blood flow against the background of insignificantly increased oxygen consumption by the heart. "
01/01/2013 - "These results suggest that both citric acid and L-malic acid have protective effects on myocardial ischemia/reperfusion injury; the underlying mechanism may be related to their anti-inflammatory, antiplatelet aggregation and direct cardiomyocyte protective effects. "
01/01/2013 - "The cardioprotective effects of citric Acid and L-malic Acid on myocardial ischemia/reperfusion injury."
01/01/2013 - "In in vivo rat model of myocardial ischemia/reperfusion injury, we found that treatments with citric acid and L-malic acid significantly reduced myocardial infarct size, serum levels of TNF-α, and platelet aggregation. "
|1.||Adenosine Triphosphate (ATP)
|2.||Aspartic Acid (Aspartate)
|6.||Citric Acid (Citrate)
|8.||Etoposide (VP 16)
|9.||Idarubicin (4 Demethoxydaunorubicin)