benextramine

RN given refers to parent cpd

Also Known As:

N,N''-(dithiodi-2,1-ethanediyl)bis(N'-(2-methoxyphenylmethyl)-1,6-hexanediamine) tetrahydrochloride; N,N'-BMBAC; N,N'-bis(o-methoxybenzylaminohexyl)cystamine; N,N'-bis-(O-methoxybenzylaminohexyl)-cystamine; benextramine tetrahydrochloride

Networked: 6 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amines: 4871
  - Ethylamines: 5
    - Cystamine: 222
      - benextramine: 6

Experts

1.	Cozza, Giorgio: 1 article (12/2019)
2.	Di Paolo, Maria Luisa: 1 article (12/2019)
3.	Milelli, Andrea: 1 article (12/2019)
4.	Minarini, Anna: 1 article (12/2019)
5.	Minniti, Elirosa: 1 article (12/2019)
6.	Rosini, Michela: 1 article (12/2019)
7.	Sarno, Stefania: 1 article (12/2019)
8.	Ursini, Fulvio: 1 article (12/2019)
9.	Zonta, Francesca: 1 article (12/2019)
10.	Bodenstein, Johannes: 1 article (08/2005)

Related Diseases

1.	Neuroblastoma 12/01/2019 - "The effectiveness of benextramine in inactivating MAOs was demonstrated in SH-SY5Y neuroblastoma cell line. " 08/01/2005 - "We studied noncompetitive antagonism by phenoxybenzamine and benextramine at alpha(2A)-adrenoceptors in stably transfected Chinese hamster ovary cells, benextramine and 4-diphenylacetoxy-N-[2-chloroethyl]piperidine hydrochloride (4-DAMP mustard) at endogenous muscarinic acetylcholine (mACh) receptors in human neuroblastoma SH-SY5Y cells, and benextramine at serotonin 5-HT(2A) receptors in stably transfected SH-SY5Y cells. "
2.	Neurodegenerative Diseases (Neurodegenerative Disease) 12/01/2019 - "These results demonstrated for the first time that benextramine and its derivatives can inactivate human MAOs exploiting a mechanism different from that of the classical MAO inhibitors and could be a starting point for the development of pharmacological tools in neurodegenerative diseases."
3.	Tachycardia (Tachyarrhythmias) 02/10/1984 - "The presence of benextramine also caused a small tachycardia in both rabbit and guinea pig right atria which was probably due to the release of endogenous noradrenaline. "
4.	Lordosis 11/01/1992 - "Benextramine treatment attenuated the inhibitory effects of progesterone on receptivity (lordosis quotients and percent of responding animals) without affecting either proceptive or rejection behaviors. "
5.	Hyperglycemia 09/01/1988 - "The hyperglycemia induced by submaximal doses of UK 14.304 was antagonized by the centrally and peripherally acting alpha-2 adrenoceptor antagonists rauwolscine, yohimbine, idazoxan and phentolamine, by the peripheral antagonist benextramine but not by prazosin (alpha-1 selective) or propranolol (beta adrenergic). "

Related Drugs and Biologics

1.	Acetylcholine (Acetylcholine Chloride)
2.	Idazoxan
3.	Cholinergic Agents (Cholinergics)
4.	Adrenergic Agents (Adrenergic Drugs)
5.	Yohimbine (Yocon)
6.	Serotonin (5 Hydroxytryptamine)
7.	Adrenergic Receptors (Adrenergic Receptor)
8.	Propranolol (Inderal)
9.	Progesterone
10.	Prazosin (Minipress)