nidogen (entactin)

basal lamina-associated sulfated glycoprotein; GenBank AJ224450 (rat); RefSeq NM_010917 (mouse); NM_002508 (human)

Also Known As:

entactin; NID1 protein, human; Nid protein, rat; Nid1 protein, mouse; Nid1 protein, rat; entactin protein, human; entactin protein, rat; entactin-1 protein, mouse; nidogen 1; nidogen 1 protein, human; nidogen 1 protein, mouse; nidogen protein, rat; nidogen-1

Networked: 175 relevant articles (1 outcomes, 13 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Nischt, Roswitha: 6 articles (11/2014 - 12/2006)
2.	Smyth, Neil: 4 articles (01/2014 - 12/2006)
3.	Miosge, Nicolai: 3 articles (04/2012 - 05/2008)
4.	Mokkapati, Sharada: 3 articles (04/2012 - 03/2007)
5.	Lee, Hyun Kyoung: 3 articles (08/2009 - 04/2006)
6.	Park, Hwan Tae: 3 articles (08/2009 - 04/2006)
7.	Seo, In Ae: 3 articles (08/2009 - 04/2006)
8.	Schenke-Layland, Katja: 2 articles (01/2022 - 02/2021)
9.	Pihlajaniemi, Taina: 2 articles (04/2019 - 05/2007)
10.	Zhang, Ying: 2 articles (05/2017 - 02/2015)

Related Diseases

1.	Infections 01/01/2023 - "HCMV Infection Reduces Nidogen-1 Expression, Contributing to Impaired Neural Rosette Development in Brain Organoids." 01/01/2021 - "While potentially beneficial for virus dissemination, HCMV-induced elimination of NID1 may underlie negative ramifications to the infected fetus.IMPORTANCE We have found that HCMV infection promotes the elimination of the developmentally important basement membrane protein nidogen 1 (NID1) from its host. " 01/01/1988 - "Absorption of highly reactive G alpha G antibodies with purified murine laminin and nidogen, two basement membrane proteins, almost abolished G alpha G reactivity, suggesting the identity of anti-G alpha G with laminin and nidogen antibodies previously reported as elevated in Kinetoplastida infections. "
2.	Neoplasms (Cancer) 11/15/2013 - "Our studies also reveal that the cleavage of nidogen-1 and -2 is partially inhibited in human tumor samples. " 04/15/2022 - "The knockdown of Nidogen-1, but not that of Hspg2, led to reduced susceptibility of the tumor cells to neutrophil cytotoxicity. " 04/15/2022 - "Both Nidogen-1 and Hspg2 were found to be expressed on the tumor cell surface. " 04/04/2019 - "The identification of nidogen-1 as an endothelial-derived inhibitor of migration of distinct cancer cell types reveals a novel mechanism of endothelial control over cancer progression." 11/15/2013 - "The increased expression of ADAMTS1 was accompanied by increased proteolysis of nidogen-1 and -2 and their almost complete removal from vascular structures, together with major morphological alterations of tumor blood vessels and a decreased vessel density. "
3.	Neoplasm Metastasis (Metastasis) 01/01/2022 - "This study aimed to investigate the potential role of nidogen 1 (NID1), a basement membrane component, in the growth and metastasis of salivary gland adenoid cystic carcinoma (SACC) and the underlying molecular mechanism. " 11/07/2023 - "Nidogen-1/NID1 Function and Regulation during Progression and Metastasis of Colorectal Cancer." 11/01/2020 - "Here, it is found that nidogen 1 (NID1) in metastatic HCC cell-derived extracellular vesicles (EVs) promotes pre-metastatic niche formation in the lung by enhancing angiogenesis and pulmonary endothelial permeability to facilitate colonization of tumor cells and extrahepatic metastasis. " 04/01/2012 - "Taken together, these results suggest that absence of nidogen 2 might result in subtle changes of endothelial BMs in the lung, which would allow faster passage of tumor cells through these BMs, leading to a higher metastasis rate and more larger tumors." 02/28/2007 - "Loss of nidogen expression may favor invasion and metastasis of cancer cells by loosening cell interaction with basal membrane and by weakening the strength of the basement membrane itself, first barrier from the connective vascularized matrix."
4.	Carcinoma (Carcinomatosis) 02/01/2015 - "Receiver operating characteristic curve analysis for nidogen-1 showed that it could discriminate patients with ovarian serous carcinomas from healthy controls [areas under the curve (AUC): 0. " 03/01/1999 - "The results show that nidogen is produced by human carcinoma cells both in vitro and in vivo." 03/01/1999 - "There was strong immunoreactivity for nidogen in tumour stroma, BM of carcinoma cell nests, and endothelial basal lamina, but no conclusions could be drawn regarding histological grade and immunostaining patterns, because stromal production could not be ruled out. " 09/15/1992 - "We report here the isolation and identification of the plasma membrane receptor for entactin from PC-3 human prostate carcinoma cells which attach and spread on entactin. " 02/01/2015 - "This study aimed to examine the plasma levels of nidogen-1 in a large patient population to evaluate its effectiveness in ovarian serous carcinoma and expression in tumor tissues. "
5.	Ovarian Neoplasms (Ovarian Cancer) 05/16/2017 - "Nidogen-1 (NID1) has been identified as a novel candidate diagnostic biomarker of ovarian cancer in our previous study. " 02/01/2015 - "Our study previously showed that basement membrane protein, nidogen-1 plasma level was significantly increased in ovarian cancer patients. " 03/01/2010 - "Nidogen-2: a new serum biomarker for ovarian cancer."

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Laminin (Merosin)
3.	Biomarkers (Surrogate Marker)
4.	Collagen
5.	nidogen (entactin)
6.	Collagen Type IV (Type IV Collagen)
7.	Antibodies
8.	Messenger RNA (mRNA)
9.	Protein Isoforms (Isoforms)
10.	Monoclonal Antibodies

Related Therapies and Procedures

1.	Neoadjuvant Therapy
2.	Axotomy
3.	Nephrectomy