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DN 1417
RN given refers to parent cpd
Also Known As:
DN 1417 citrate (1:1); DN 1417, (S)-isomer; DN-1417; gamma-butyrolactone-gamma-carbonyl-His-ProNH2; gamma-butyrolactone-gamma-carbonyl-histidyl-prolinamide citrate; L-Prolinamide, N-((tetrahydro-5-oxo-2-furanyl)carbonyl)-L-histidyl-
Networked:
16
relevant articles (
3
outcomes,
1
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Hormones, Hormone Substitutes, and Hormone Antagonists
Hormones: 80400
Peptide Hormones: 1347
Hypothalamic Hormones: 68
Pituitary Hormone-Releasing Hormones: 39
Thyrotropin-Releasing Hormone: 1449
DN 1417: 16
Amino Acids, Peptides, and Proteins: 1
Proteins: 484843
Nerve Tissue Proteins: 2
Neuropeptides: 6772
Thyrotropin-Releasing Hormone: 1449
DN 1417: 16
Hypothalamic Hormones: 68
Pituitary Hormone-Releasing Hormones: 39
Thyrotropin-Releasing Hormone: 1449
DN 1417: 16
Peptides: 82426
Neuropeptides: 6772
Hypothalamic Hormones: 68
Pituitary Hormone-Releasing Hormones: 39
Thyrotropin-Releasing Hormone: 1449
DN 1417: 16
Peptide Hormones: 1347
Hypothalamic Hormones: 68
Pituitary Hormone-Releasing Hormones: 39
Thyrotropin-Releasing Hormone: 1449
DN 1417: 16
Oligopeptides: 519
Thyrotropin-Releasing Hormone: 1449
DN 1417: 16
Related Diseases
1.
Drug Resistant Epilepsy
07/01/1989 - "
Clinical study of oral administration of DN-1417, a TRH analog, in patients with intractable epilepsy.
"
01/01/1983 - "
In 1981, Inanaga et al reported on the efficacy of DN-1417 (a TRH analog) in the treatment of degenerative myoclonus epilepsy and other forms of intractable epilepsy.
"
2.
Schizophrenia (Dementia Praecox)
10/01/1986 - "
These results suggest that the positive symptoms of schizophrenia are improved by DN-1417 treatment, and that the alterations in BPRS scores coincide with changes in the frontal EEG.
"
3.
Myoclonic Epilepsies (Myoclonic Encephalopathy)
01/01/1983 - "
In 1981, Inanaga et al reported on the efficacy of DN-1417 (a TRH analog) in the treatment of degenerative myoclonus epilepsy and other forms of intractable epilepsy.
"
01/01/1983 - "
Following this report, we studied the efficacy and safety of DN-1417 treatment in 10 intractable epileptic children ranging in age from 6 months to 11 years (mean 4 years), including 7 with Lennox syndrome (LS), 2 with West syndrome (WS) and 1 with degenerative myoclonus epilepsy (DME).
"
4.
Brain Ischemia (Cerebral Ischemia)
03/01/1985 - "
We investigated the ameliorating effects of DN-1417 (a TRH analog) on the changes of behavior, EEG, neurochemical parameters and regional cerebral blood flow (rCBF) in rats with global cerebral ischemia.
"
03/01/1985 - "
As a result, it is identified that DN-1417 ameliorates the disturbance of consciousness supposedly caused by behavioral and EEG abnormalities during recirculation following the temporary cerebral ischemia, and the effect of DN-1417 seems to be mediated by normalizing of alterations in the brain monoaminergic and cholinergic systems, as well as rCBF, and the effectiveness for disturbance of consciousness in clinical situations would be expected.
"
03/01/1985 - "
DN-1417 shortened significantly the recovery times of righting reflex (RR) and spontaneous movement (SM) at 2.5 mg/kg and higher doses, and it recovered effectively the EEG activity at 10 mg/kg during recirculation after 10-min cerebral ischemia.
"
5.
Hyperglycemia
07/05/1988 - "
To study the role of the pituitary in mediating this action, we have evaluated the effect of TRH analogs lacking hypophysiotropic activity, acid-TRH and DN 1417, in blocking glucagon-induced hyperglycemia in mice.
"
07/05/1988 - "
It was found that central injection of acid-TRH or DN 1417 (0.1-10 micrograms) fully mimics TRH in blocking glucagon (5 micrograms)-stimulated hyperglycemia.
"
Related Drugs and Biologics
1.
Cholinergic Agents (Cholinergics)
2.
Glucagon (Glukagon)
3.
Acids
4.
Thyrotropin-Releasing Hormone (Protirelin)
5.
Cycloheximide (Cicloheximide)
6.
Anticonvulsants (Antiepileptic Drugs)
7.
Citric Acid (Citrate)
8.
Protein Synthesis Inhibitors
9.
Physostigmine
10.
Pentobarbital (Nembutal)
Related Therapies and Procedures
1.
Oral Administration