|1.||Schofield, Christopher J: 11 articles (09/2014 - 08/2003)|
|2.||Bhattacharya, R: 7 articles (03/2011 - 11/2001)|
|3.||Vijayaraghavan, R: 6 articles (03/2011 - 11/2001)|
|4.||Kurhaliuk, N M: 5 articles (01/2003 - 01/2000)|
|5.||McDonough, Michael A: 4 articles (09/2014 - 02/2007)|
|6.||Ge, Wei: 4 articles (09/2014 - 02/2010)|
|7.||Flashman, Emily: 4 articles (03/2014 - 10/2005)|
|8.||Ratcliffe, Peter J: 4 articles (03/2014 - 08/2003)|
|9.||Loenarz, Christoph: 4 articles (03/2014 - 02/2010)|
|10.||Hewitson, Kirsty S: 4 articles (10/2010 - 08/2003)|
01/01/1990 - "Efficacy of alpha-ketoglutaric acid as an effective antidote in cyanide poisoning in dogs."
11/01/2001 - "Acute toxicity studies of alpha-ketoglutarate: a promising antidote for cyanide poisoning."
05/01/2011 - "Development of nano alpha-ketoglutarate nebulization formulation and its pharmacokinetic and safety evaluation in healthy human volunteers for cyanide poisoning."
03/01/2011 - "Effect of alpha-ketoglutarate on neurobehavioral, neurochemical and oxidative changes caused by sub-chronic cyanide poisoning in rats."
01/01/2011 - "Oral treatment of alpha-ketoglutarate (A-KG) is known to antagonise experimental cyanide poisoning in rodents. "
03/01/2009 - "In this study, we show that alpha-ketoglutarate (KG) mitigates the Al-mediated nuclear accumulation of hypoxia inducible factor-1alpha (HIF-1alpha) in cultured human hepatocytes (HepG2). "
01/11/2007 - "Thus, this study demonstrates that the regulation of ATF3 under anoxia is independent of 2-oxoglutarate dioxygenase, HIF-1 and p53, presumably involving multiple regulatory pathways."
08/04/2015 - "A New Hydroxy Metabolite of 2-Oxoglutarate Regulates Metabolism in Hypoxia."
01/01/2011 - "Human AlkB homologue 5 is a nuclear 2-oxoglutarate dependent oxygenase and a direct target of hypoxia-inducible factor 1α (HIF-1α)."
10/15/2010 - "Structural basis for binding of cyclic 2-oxoglutarate analogues to factor-inhibiting hypoxia-inducible factor."
04/01/2011 - "Treatment with 2-oxoglutarate (2.28 g/l drinking water) for between 7 and 21 days attenuated the neuronal death and reactive astrogliosis in this model of experimental ischemia by 20-50%. "
04/01/2011 - "The neuroprotective effect of 2-oxoglutarate in the experimental ischemia of hippocampus."
06/01/2002 - "The inhibitory effect of the reaction product 2-oxoglutarate was higher under normal conditions than in ischemia (the Ki values were 0.22 and 0.75 mM, respectively). "
05/01/2002 - "IP and CP protection is expressed through better energetic status and by higher recovery of the TCA cycle activity or enhanced mitochondria-cytosol transport of alpha-ketoglutarate on reperfusion in addition to metabolic changes during ischemia. "
02/01/1981 - "Mitochondrial respiratory control indices (RCI) were assayed in a second group of seven dogs prior to ischemia, at contracture initiation, and at contracture completion and were, respectively, 11.5 +/- 1.18, 3.1 +/- 0.43 and 1.76 +/- 0.29 (alpha ketoglutarate as substrate). "
|4.||Wounds and Injuries (Trauma)
03/24/1990 - "alpha-ketoglutarate supplementation may improve recovery after trauma."
09/01/1996 - "We have evaluated the relative metabolic efficacy of four isonitrogenous diets with or without the addition of alpha-ketoglutarate (alpha KG) or ornithine (ORN), in a rat trauma (bilateral femur fracture) model. "
01/01/1999 - "The recent literature suggests that the administration of alpha-ketoglutarate in combination with ornithine improves gut morphology and functions, counteracts trauma-induced dysimmunity and exerts anabolic/anticatabolic actions on protein metabolism."
09/01/1995 - "The aim of this study was to characterize a human trauma model using patients undergoing total hip replacement, and furthermore to investigate whether glutamine or alpha-ketoglutarate alone without TPN can prevent the postoperative decrease in muscle free glutamine. "
02/01/1995 - "Ornithine (Orn; alpha-ketoglutarate (alpha KG) salt) and arginine (Arg) supplementation of enteral diets has been advocated in the treatment of hypercatabolism of trauma patients, but both compounds are subject to extensive hepatic metabolism. "
|5.||Chronic Kidney Failure (Chronic Renal Failure)
02/01/1974 - "[Single injection clearance of alpha-ketoglutarate in chronic renal failure (author's transl)]."
01/01/1991 - "Chronic renal failure (CRF) is associated with impaired oxidation of alpha-ketoglutarate (alpha-KG) by heart mitochondria, and previous data indicated that this derangement is due to the state of secondary hyperparathyroidism of CRF. "
12/01/1988 - "The present study evaluated in rats the effects of four days administration of PTH and 21 days of chronic renal failure (CRF) with and without excess PTH on oxidation of alpha-ketoglutarate, beta-hydroxybutyric acid, LCFA and short chain fatty acids (SCFA). "
|2.||Succinic Acid (Succinate)
|7.||Calcium Carbonate (Limestone)
|10.||Glutamic Acid (Glutamate)
|1.||Renal Dialysis (Hemodialysis)
|3.||Hip Replacement Arthroplasty (Total Hip Replacement)