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prothrombin fragment 1

N-terminal portion of prothrombin released on treatment with thrombin: 156 residues
Also Known As:
prothrombin profragment-1; Blood-coagulation factor II, fragment 1
Networked: 117 relevant articles (4 outcomes, 8 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Rotunno, Crescenzia: 2 articles (04/2014 - 08/2012)
2. Paparella, Domenico: 2 articles (04/2014 - 08/2012)
3. De Palo, Micaela: 2 articles (04/2014 - 08/2012)
4. Guida, Pietro: 2 articles (04/2014 - 08/2012)
5. Wada, Hideo: 2 articles (11/2012 - 07/2008)
6. Hatada, Tsuyoshi: 2 articles (11/2012 - 07/2008)
7. Nobori, Tsutomu: 2 articles (11/2012 - 07/2008)
8. Liu, Jihong: 2 articles (12/2011 - 01/2005)
9. Ye, Zhangqun: 2 articles (12/2011 - 01/2005)
10. Wang, Shaogang: 2 articles (12/2011 - 01/2005)

Related Diseases

1. Venous Thrombosis (Deep-Vein Thrombosis)
2. Inflammation
04/01/2014 - "Interleukin 6 (a marker of inflammation), prothrombin fragment 1-2 (a marker of thrombin generation), plasmin-antiplasmin complex (a marker of fibrinolysis), and platelet factor 4 (a marker of platelet activation) were measured at six different times. "
08/01/2012 - "Myocardial damage was evaluated measuring cardiac troponin I. Interleukin (IL)-6 (a marker of inflammation), prothrombin fragment 1-2 (PF-1.2, a marker of thrombin generation), plasmin-antiplasmin complex (PAP, a marker of fibrinolysis), and platelet factor 4 (PF4, a marker of platelet activation) were measured. "
04/01/2004 - "We prospectively measured the plasma levels of activated factor XII, cleaved kininogen, prothrombin fragment 1 + 2 (as indexes of the contact phase and coagulation activation), and interleukin-6 and C-reactive protein (CRP) (as indexes of inflammation) in 39 patients hospitalized for AMI within 12 hours of symptom onset: 26 receiving thrombolytic therapy and 13 heparin alone. "
03/01/2006 - "The magnitude of the surgical trauma was assessed by measuring markers of coagulation (prothrombin fragment 1 + 2), endothelial activation (von Willebrand factor), inflammation [leukocytes, interleukin-6, -8 and -10, granulocyte macrophage colony-stimulating factor, and C-reactive protein (CRP)], and endocrine stress (cortisol) in blood collected before operation, 4 h postincision, and on postoperative day 2. Leukocyte counts and interleukin-6 and CRP levels increased in both groups, with the CRP increase being significantly greater in the OR group. "
03/01/2003 - "In a prospective study, prothrombin fragment 1 and 2 (F1.2), thrombin-antithrombin complex (TAT), antithrombin, D-dimer, plasmin-alpha(2)-antiplasmin complex (PAP) and plasminogen activator inhibitor-1 (PAI-1) were measured in 20 patients with Crohn's disease (CD), 18 with ulcerative colitis (UC), and 19 with giant cell arteritis during active and inactive disease, as well as in 51 controls without inflammation. "
3. Hypertension (High Blood Pressure)
01/01/2001 - "In 22 patients with newly diagnosed uncomplicated essential hypertension, in 40 hypertensive patients with clinically evident vascular complications (20 patients with controlled blood pressure and 20 with uncontrolled and high blood pressure) and in 20 normotensive sex- and age-matched subjects, two indexes of thrombin generation and action, namely prothrombin fragment 1 + 2 (F1 + 2) and fibrinopeptide A (FPA) were evaluated. "
11/01/2000 - "Age, blood pressure, duration of hypertension, and plasma levels of fibrinogen, D-dimer, prothrombin fragment 1 + 2, and lipoprotein(a) were significantly greater in these patients than in those with normal renal function; these differences persisted after adjustment for potential confounders. "
01/01/2013 - "In 205 patients with untreated essential hypertension, we measured components of the renin-angiotensin-aldosterone system, plasma levels of fibrinogen, D-dimer, prothrombin fragment 1 + 2 (F1 + 2), and plasminogen activator inhibitor-1 (PAI-1), and assessed cardiac characteristics with standard echocardiography. "
05/01/2002 - "In 78 non-diabetic, normotensive first-degree relatives of type 2 diabetic patients (47 without a family history of hypertension and 31 with a family history of hypertension) and in 36 normoglycemic, normotensive subjects with no family history of hypertension, we evaluated plasma levels of fasting glucose and insulin, tissue-type plasminogen activator (t-PA), plasminogen activator-inhibitor (PAI-1), D-dimer (DD) and prothrombin fragment 1 + 2 (F1+2). "
4. Wounds and Injuries (Trauma)
5. Hypoglycemia (Reactive Hypoglycemia)

Related Drugs and Biologics

1. Thrombin
2. fibrin fragment D (D-dimer)
3. von Willebrand Factor
4. Antithrombin III
5. Fibrinogen (Factor I)
6. Plasminogen Activators (Plasminogen Activator)
7. Interleukin-6 (Interleukin 6)
8. C-Reactive Protein
9. Heparin (Liquaemin)
10. P-Selectin

Related Therapies and Procedures

1. Drug Therapy (Chemotherapy)
2. Aftercare (After-Treatment)
3. Hip Replacement Arthroplasty (Total Hip Replacement)
4. Coronary Atherectomy
5. Mammaplasty (Breast Reconstruction)