urotensin II

11/01/2009 - "The sources of secretion and clearance of plasma urotensin II (UII) in the human circulation remain uncertain and may be relevant to understanding the role of UII in human physiology and cardiovascular disease. "
03/15/2017 - "Since the regulation of the urotensin II/urotensin II receptor offers a great potential for therapeutic strategies related to the treatment of cardiovascular diseases, the study of selective and potent antagonists for urotensin II receptor is more fascinating. "
05/01/2008 - "Although future studies are required to clarify whether these mechanisms are also important in the clinical setting, this report supports an emerging new role for urotensin II in the pathogenesis and progression of cardiovascular disease."
02/14/2023 - "Accumulated evidence shows that elevated urotensin II (UII) levels are associated with cardiovascular diseases. "
11/01/2019 - "Novel insights into the role of urotensin II in cardiovascular disease."

02/01/2020 - "The urotensin II receptor antagonist DS37001789 ameliorates mortality in pressure-overload mice with heart failure."
10/01/2021 - "Urotensin II (UII) has been known closely related to cardiac remodeling and the development of heart failure. "
09/01/2015 - "A stop‑gain mutation in urotensin II receptor (UTS2R) (p.S241X), which is associated with congestive heart failure, was identified in the proband and in one other affected family member. "
04/01/2009 - "Urotensin II (UII) and its receptor UT are involved in control of the cardiovascular system and are implicated in heart failure. "
12/01/2006 - "Urotensin II (UTII) is recently discovered neurohumoral factor influencing function and structure of the myocardium and remodeling of the vessels, and it may contribute to pathogenesis of chronic congestive heart failure. "

07/01/2017 - "Clinical evidence, in vitro and in vivo studies have implicated urotensin II (U-II/UTS2) in the development of cardiac hypertrophy, contributing to the (patho)-physiological regulation of cardiovascular homeostasis in humans. "
01/01/2021 - "Urotensin II Induces Cardiac Fibrosis through the TGF-β/Smad Signaling Pathway during the Development of Cardiac Hypertrophy."
03/15/2017 - "These results suggest that potent and selective urotensin II receptor antagonist could efficiently attenuate both cardiac hypertrophy and dysfunction in experimental heart failure. "
06/01/2011 - "EGFR trans-activation by urotensin II receptor is mediated by β-arrestin recruitment and confers cardioprotection in pressure overload-induced cardiac hypertrophy."
12/01/2010 - "Urotensin II receptor antagonist attenuates monocrotaline-induced cardiac hypertrophy in rats."

01/01/2018 - "Clinical significance of increased urotensin II levels in acute myocardial infarction."
05/02/2007 - "Urotensin II is raised in acute myocardial infarction and low levels predict risk of adverse clinical outcome in humans."
03/01/2008 - "In patients with acute cardiac ischemia, circulating urotensin II is lower than normal and low plasma urotensin II signals a higher risk of adverse clinical events following myocardial infarction. "
06/16/2006 - "Exercise urotensin II dynamics in myocardial infarction survivors with and without hypertension."
06/03/2015 - "Plasma urotensin II (UII) has been observed to be raised in patients with acute myocardial infarction; suggesting a possible cardiac protective role for this peptide. "

12/01/2009 - "Elevated expression of urotensin II and its receptor in great artery of type 2 diabetes and its significance."
12/01/2007 - "To investigate the association between a polymorphism (rs228648) of urotensin II (UT-II) gene and type 2 diabetes in pedigrees. "
12/01/2007 - "[Relationship between polymorphism of urotensin II gene and type 2 diabetes in pedigrees]."
02/01/2005 - "[Genetic variations of urotensin II gene in type 2 diabetes]."
10/01/2004 - "Genetic variations at urotensin II and urotensin II receptor genes and risk of type 2 diabetes mellitus in Japanese."