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ribonuclease C

high substrate specificity for poly C

Also Known As:

RNase C; poly C-specific ribonuclease

Networked: 6 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Hydrolases: 2166
    - Esterases: 1574
      - Ribonucleases: 2046
        Endoribonucleases: 176
        ribonuclease C: 6
      - Endonucleases: 1227
        Endoribonucleases: 176
        ribonuclease C: 6

Experts

1.	Kusnierz-Cabala, B: 2 articles (12/2004 - 09/2003)
2.	Naskalski, J W: 2 articles (12/2004 - 09/2003)
3.	Ceranowicz, P: 1 article (12/2004)
4.	Dembinski, A: 1 article (12/2004)
5.	Dembinski, M: 1 article (12/2004)
6.	Konturek, S J: 1 article (12/2004)
7.	Pawlik, W W: 1 article (12/2004)
8.	Warzecha, Z: 1 article (12/2004)
9.	Kedra, B: 1 article (09/2003)
10.	Panek, J: 1 article (09/2003)

Related Diseases

1.	Pancreatitis 12/01/2004 - "GSE reduced the pancreatitis-evoked increase in serum lipase and poly-C specific ribonuclease activity, and attenuated the marked fall in pancreatic blood flow and pancreatic DNA synthesis. " 09/01/2003 - "Poly-C specific ribonuclease activity correlates with increased concentrations of IL-6, IL-8 and sTNFR55/sTNFR75 in plasma of patients with acute pancreatitis." 09/01/2003 - "Plasma pancreatic-type Poly-C specific ribonuclease (P-RNase)-enzyme activity increases in patients with acute pancreatitis (AP) who develop pancreatic necrosis and severe disease course. " 08/01/1981 - "RNase C is immunologically identical to the poly(C)-active RNase in various human sera, including samples obtained from normal individuals, patients with pancreatic carcinoma, pancreatitis, or other malignant and nonmalignant diseases. "
2.	Pancreatic Neoplasms (Pancreatic Cancer) 10/01/1982 - "Ribonuclease C and pancreatic secretory proteins in the peripheral circulation before and after pancreatectomy for pancreatic cancer." 08/01/1981 - "RNase C is immunologically identical to the poly(C)-active RNase in various human sera, including samples obtained from normal individuals, patients with pancreatic carcinoma, pancreatitis, or other malignant and nonmalignant diseases. "
3.	Acute Necrotizing Pancreatitis 09/01/2003 - "Plasma pancreatic-type Poly-C specific ribonuclease (P-RNase)-enzyme activity increases in patients with acute pancreatitis (AP) who develop pancreatic necrosis and severe disease course. "
4.	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 10/01/1990 - "The activities of RNase (RNase-U and RNase-C) were determined in the serum and leukocytes of 277 patients with 14 cases of various kinds of eosinophilia (not less than 10(3)/microliters), 28 cases of chronic myelocytic leukemia (CML), using polyuridylic acid and polycytidylic acid as synthetic substrates according to the method of Raddi et al. Serum RNase-U activity, serum RNase-C activity and the activity ratio (U/C x 10(-3)) were 55 +/- 14 U, 1,280 +/- 235 U and 44 +/- 11 (mean +/- SD), 196 +/- 137, 1,992 +/- 1,134 U and 97 +/- 38, and 110 +/- 50 U, 1,854 +/- 625 U and 65 +/- 13 for normal subjects, eosinophilia and CML (untreated), respectively. "
5.	Weight Loss (Weight Reduction) 01/15/1985 - "The clinical data base determined on each patient included: RNAse C level, carcinoembryonic antigen (CEA) level, age, sex, race, presence (or absence of metastases, type of cancer, site of metastasis, renal function blood urea nitrogen [BUN], creatinine), hepatic function (bilirubin, alkaline phosphatase), and nutritional status (percent ideal body weight, percent weight loss, and albumin). "

Related Drugs and Biologics

1.	Ribonucleases (Ribonuclease)
2.	Poly C
3.	Interleukin-8 (Interleukin 8)
4.	Interleukin-6 (Interleukin 6)
5.	Urea (Carbamide)
6.	Proteins (Proteins, Gene)
7.	Nitrogen
8.	Lipase (Acid Lipase)
9.	Enzymes
10.	DNA (Deoxyribonucleic Acid)

Related Therapies and Procedures

1.	Pancreatectomy