|1.||Christensen, Erik I: 6 articles (11/2013 - 02/2002)|
|2.||Nielsen, Rikke: 3 articles (11/2013 - 08/2010)|
|3.||Gburek, Jakub: 3 articles (11/2010 - 02/2002)|
|4.||Kozyraki, Renata: 3 articles (11/2010 - 12/2005)|
|5.||Courtoy, Pierre J: 2 articles (06/2014 - 03/2007)|
|6.||Antignac, Corinne: 2 articles (06/2014 - 11/2013)|
|7.||Argraves, W Scott: 2 articles (05/2014 - 12/2004)|
|8.||Saito, Akihiko: 2 articles (01/2014 - 01/2007)|
|9.||Levtchenko, Elena N: 2 articles (04/2013 - 06/2008)|
|10.||van den Heuvel, Lambertus P: 2 articles (04/2013 - 06/2008)|
01/01/2012 - "A recent meta-analysis described a variant (p.Ile2984Val) in the cubilin gene (CUBN) that is associated with levels of albuminuria in the general population and in diabetics. "
01/01/2012 - "Linkage disequilibrium analysis reveals an albuminuria risk haplotype containing three missense mutations in the cubilin gene with striking differences among European and African ancestry populations."
11/01/2010 - "Furthermore, cubilin-deficient mice exhibited markedly decreased uptake of albumin by proximal tubule cells and resultant albuminuria. "
09/01/2006 - "The expression level of Cubilin in the diabetic nephropathy group was significantly decreased at week 2 after operation (P < 0.05), and it continued to decrease from week 2 to week 6. Also there was significant difference between each two time-points (P < 0.05), and the Cubilin expression level was negatively correlated with albuminuria (P < 0.01). "
09/01/2006 - "To observe the expression level of Cubilin in the renal tubules of rats with STZ-induced diabetic nephropathy, to assess its correlation with 24 hours' albuminuria, and to investigate the mechanisms of tubular dysfunction at the early stage of diabetic nephropathy. "
01/01/2011 - "This was associated with the protection against the loss of megalin/cubilin and an increase in TGF-β(1), IL-1β, and fibrosis in the kidney. "
11/01/2013 - "Lysosomal protein accumulation in the proximal tubule, mediated by megalin and cubilin endocytosis of increased amounts of filtered protein, is thought to result in inflammation and fibrosis. "
01/01/2002 - "New information about the role of cubilin and megalin in the reabsorption of filtered albumin in the proximal tubule may contribute to the elucidation of the mechanisms of the tubulotoxicity of proteinuria; inhibition of albumin reabsorption in nephrotic subjects could lower the risk of interstitial fibrosis and progressive renal insufficiency."
01/01/2011 - "Megalin/ cubilin-mediated endocytosis by proximal tubule cells of increased quantities of filtered proteins (protein overloading) in glomerular diseases appears to evoke cell stress responses resulting in increased inflammatory cytokines leading to tubulointerstitial inflammation and fibrosis. "
|3.||Wounds and Injuries (Trauma)
05/01/2014 - "These findings raise the possibility that therapeutic increase of renal cubilin expression might reduce proteinuria and increase blood levels of albumin and HDL."
10/01/2011 - "In two siblings of consanguineous parents with intermittent nephrotic-range proteinuria, we identified a homozygous deleterious frameshift mutation in the gene CUBN, which encodes cubulin, using exome capture and massively parallel re-sequencing. "
10/01/2011 - "Exome sequencing reveals cubilin mutation as a single-gene cause of proteinuria."
01/01/2011 - "We determined the molecular basis of MGA1 in both patients and discuss the involvement of the cubilin/AMN complex in this pathology and its role in the development of the proteinuria. "
03/01/2007 - "In conclusion, CFTR inactivation leads to a moderate defect in receptor-mediated PT endocytosis, associated with a cubilin defect and a significant LMW proteinuria in mouse and human. "
08/27/2009 - "These studies show the great potential of cubilin as a new target for the delivery of B(12) based conjugates for cancer diagnostics and/or treatment."
06/01/2012 - "In addition, mutations in v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS) (glycine→serine at codon 12 [G12S]); cubilin (CUBN) (isolucine→valine at codon 3189 [I3189V]; observed in 2 separate tumor samples); cadherin 1, type 1, epithelial (CDH1) (alanine→threonine at codon 617 [A617T]; observed in 2 separate tumor samples); catenin (cadherin-associated protein), beta 1, 88 kDa (CTNNB1) (asparagine→S at codon 287 [N287S]); and fibrous sheath CABYR binding protein (FSCB) (S→leucine at codon 775 [S775L]) were observed. "
|1.||LDL-Receptor Related Protein 2
|2.||Antisense RNA (Anti-Sense RNA)
|4.||Folic Acid (Vitamin M)
|6.||aspartic acid- tRNA
|7.||Vitamin B 12 (Cyanocobalamin)
|9.||Proteins (Proteins, Gene)