|1.||Shockley, Keith R: 1 article (02/2015)|
|2.||Nagai, Hiroaki: 1 article (02/2015)|
|3.||Wyde, Michael: 1 article (02/2015)|
|4.||Ton, Thai-Vu T: 1 article (02/2015)|
|5.||Gerrish, Kevin E: 1 article (02/2015)|
|6.||Pandiri, Arun R: 1 article (02/2015)|
|7.||Sills, Robert C: 1 article (02/2015)|
|8.||Peddada, Shyamal D: 1 article (02/2015)|
|9.||Clayton, Natasha P: 1 article (02/2015)|
|10.||Blackshear, Pamela E: 1 article (02/2015)|
01/01/1995 - "In male mice, 1,1-dichloroethene caused renal tumors after inhalation. "
06/01/1994 - "HCFC-141b showed an equivocal tumorigenic effect in rats (an increase in benign testicular tumors that was not dose related), while vinylidene chloride was associated with an increase in tumor incidence (kidney tumors in mice) in a single study out of 19 in which its carcinogenicity has been investigated. "
06/01/1981 - "Follow-up study on the carcinogenicity of vinyl chloride and vinylidene chloride in rats and mice: tumor incidence and mortality subsequent to exposure."
12/15/1992 - "1,1-Dichloroethylene (125 mg/kg, i.p.) and naphthalene (225 mg/kg, i.p.) caused preferential necrosis of Clara cells in control lungs and uninvolved tissue of tumor-bearing lungs. "
07/01/1998 - "This study investigates the potential of urethane-induced lung tumors to activate 1,1-dichloroethylene (DCE), a chemical that causes Clara cell damage in mice. "
11/01/2001 - "1,1-Dichloroethylene (DCE) causes hepatocellular necrosis that preferentially affects centrilobular hepatocytes. "
02/15/1997 - "Exposure to 1,1-dichloroethylene (DCE) elicits lung and liver cytotoxicities that are manifested in bronchiolar Clara cell injury and centrilobular necrosis, respectively. "
07/01/1987 - "1,1-Dichloroethylene (1,1-DCE) causes lung and liver necrosis in mice. "
08/01/1986 - "The administration of 1,1-dichloroethylene (1,1-DCE, 125 mg/kg ip) to CD-1 mice caused bronchiolar necrosis, which was accompanied by substantial covalent binding of radiolabeled compound and/or metabolite to lung. "
02/01/1986 - "Administration of a single intraperitoneal dose of 1,1-dichloroethylene (125 mg/kg, 1,1-DCE) to mice resulted in bronchiolar injury with selective necrosis of Clara cells. "
01/01/1991 - "Our objective was to determine if the previously reported protective effect of hypothyroidism against 1,1-dichloroethylene hepatotoxicity was associated with a change in distribution and covalent binding. "
01/01/1991 - "1,1-Dichloroethylene hepatotoxicity: hypothyroidism decreases metabolism and covalent binding but not injury in the rat."
11/01/1977 - "Modification of 1,1-dichloroethylene hepatotoxicity by hypothyroidism."
|1.||Urethane (Ethyl Carbamate)
|2.||dynorphin A-converting enzyme
|4.||vinylidene chloride (1,1-dichloroethylene)
|7.||Cytochrome P-450 CYP2E1 (CYP2E1)
|8.||Vinyl Chloride (Chloroethylene)