2,3-piperidinedicarboxylic acid

effective antagonist at all three types of excitatory amino acid receptors; does not depress responses to acetylcholine or substance P

Also Known As:

2,3-piperidine dicarboxylate; cis-2,3-piperidine dicarboxylic acid; 2,3-Piperidinedicarboxylic acid, cis-

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Piperidines: 17
    - Pipecolic Acids
      - 2,3-piperidinedicarboxylic acid: 5
- Heterocyclic Acids
  - Pipecolic Acids
    - 2,3-piperidinedicarboxylic acid: 5

Related Diseases

1.	Ganglion Cysts (Ganglion) 03/21/1989 - "When intravitreally injected into the frog in vivo, 2-amino-4-phosphonobutyrate (APB) and cis-2,3-piperidine dicarboxylic acid (PDA) showed opposite effects on ON and OFF retinal channels: APB abolished the ON responses in the electroretinogram and in ganglion cell activity, and increased OFF responses. " 11/01/1988 - "4. General glutamate antagonists such as cis-2,3-piperidine dicarboxylic acid (PDA) and kynurenic acid blocked the light input to all ganglion cells. "
2.	Tremor (Tremors) 10/15/1984 - "The onset pressures for the tremor, myoclonus and convulsions seen in the high pressure neurological syndrome (HPNS) are increased following cis-2,3-piperidine dicarboxylic acid 1 mmol/kg in the rat. " 01/01/1987 - "These are blocked in a dose-dependent manner by cis-2,3-piperidine dicarboxylic acid (PDA), an antagonist of quisqualate (QA)-preferring (A2) and kainate (KA)-preferring (A3) glutamate receptors (ED50s; 2.8 micrograms, rigidity; 1.4 micrograms, convulsions; 2.4 micrograms, resting tremor). "
3.	Myoclonus (Nocturnal Myoclonus) 10/15/1984 - "The onset pressures for the tremor, myoclonus and convulsions seen in the high pressure neurological syndrome (HPNS) are increased following cis-2,3-piperidine dicarboxylic acid 1 mmol/kg in the rat. " 04/01/1984 - "Myoclonus or convulsions occurred at various times after the intraventricular injection of cis-2,3-piperidine dicarboxylic acid, trans-2,3-, cis-2,4-, cis-2,5- and cis-2,6-, piperidine dicarboxylic acids, and after the intraperitoneal injection of trans-2,3-piperidine dicarboxylic acid. "
4.	High Pressure Neurological Syndrome (High Pressure Nervous Syndrome) 10/15/1984 - "The onset pressures for the tremor, myoclonus and convulsions seen in the high pressure neurological syndrome (HPNS) are increased following cis-2,3-piperidine dicarboxylic acid 1 mmol/kg in the rat. "

Related Drugs and Biologics

1.	Excitatory Amino Acid Antagonists
2.	Glutamate Receptors (Glutamate Receptor)
3.	Quisqualic Acid
4.	Retinaldehyde (Retinal)
5.	Kynurenic Acid (Kynurenate)
6.	Kainic Acid (Kainate)
7.	Dicarboxylic Acids
8.	Acids
9.	piperidine

Related Therapies and Procedures

1.	Intraventricular Injections
2.	Intraperitoneal Injections