HOME
PRODUCTS
COMPANY
CONTACT
FAQ
Research
Dictionary
Pharma
Sign Up
FREE
or
Login
Username:
Password:
Remember login
Login
Send password reminder...
tilomisole
structure given in first source
Also Known As:
3-(p-chlorophenyl)thiazolo(3,2-a)benzimidazole-2-acetic acid; NSC 310633; Wy 18251; Wy-18,251; Wy-18251
Networked:
11
relevant articles (
3
outcomes,
3
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Benzimidazoles: 245
tilomisole: 11
Related Diseases
1.
Rheumatoid Arthritis
10/01/1985 - "
The combined immunomodulatory and antiinflammatory activity of Wy-18,251 suggests that this agent may have therapeutic promise in certain immunoinflammatory diseases including rheumatoid arthritis.
"
01/01/1985 - "
The ability of Wy-18,251 to augment Ts activity could be therapeutically useful in the treatment of those autoimmune diseases, such as rheumatoid arthritis and systemic lupus erythematosus, in which hyperactive B cell function is a characteristic feature.
"
02/01/1996 - "
Tilomisole, imuthiol, and mycophenolate mofetil have been studied in limited rheumatoid arthritis trials with positive effects.
"
08/01/1987 - "
Effects of tilomisole, indomethacin and levamisole on regulation of Epstein Barr virus-induced B cell proliferation by peripheral blood mononuclear cells from normal individuals and patients with rheumatoid arthritis.
"
2.
Inflammation (Inflammations)
05/01/1992 - "
A significant reduction in anti-inflammatory activity was observed with the tilomisole/aspirin combination in acute inflammation.
"
05/01/1992 - "
Interaction studies of tilomisole, aspirin, and naproxen in acute and chronic inflammation with assessment of gastrointestinal irritancy in the rat.
"
3.
Systemic Lupus Erythematosus (Libman-Sacks Disease)
01/01/1985 - "
The ability of Wy-18,251 to augment Ts activity could be therapeutically useful in the treatment of those autoimmune diseases, such as rheumatoid arthritis and systemic lupus erythematosus, in which hyperactive B cell function is a characteristic feature.
"
4.
Autoimmune Diseases (Autoimmune Disease)
01/01/1985 - "
The ability of Wy-18,251 to augment Ts activity could be therapeutically useful in the treatment of those autoimmune diseases, such as rheumatoid arthritis and systemic lupus erythematosus, in which hyperactive B cell function is a characteristic feature.
"
5.
Arthritis (Polyarthritis)
01/01/1987 - "
Moreover, these data suggest that tilomisole has potential disease-modifying activity in arthritis, which is currently being more closely examined in clinical trials.
"
01/01/1987 - "
The effects of the experimental immunomodulatory agent tilomisole (Wy-18,251; (3-(p-chlorophenyl) thiazolo [3,2-a]benzimidazole-2-acetic acid) on disease development and immune function in rats with adjuvant-induced arthritis was assessed in comparison with indomethacin and levamisole.
"
Related Drugs and Biologics
1.
Aspirin (Acetylsalicylic Acid)
2.
Naproxen (Naprosyn)
3.
Mycophenolic Acid (Cellcept)
4.
Ditiocarb (Sodium Diethyldithiocarbamate)
5.
Levamisole (Decaris)
6.
benzimidazole
7.
Indomethacin (Indometacin)
8.
1- (2',6'- difluorophenyl)- 1H,3H- thiazolo(3,4- a)benzimidazole
9.
Acetic Acid (Vinegar)
10.
Tilorone (Tilorone Hydrochloride)
Related Therapies and Procedures
1.
Therapeutics