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6-hydroxy-7-methoxyphthalide (MA-2)

metabolite of noscapine; structure in first source

Also Known As:

MA-2; 1(3H)-Isobenzofuranone, 6-hydroxy-7-methoxy-

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Carboxylic Acids: 973
  - Carbocyclic Acids
    - Phthalic Acids: 1
      - Phthalic Anhydrides: 4
        6-hydroxy-7-methoxyphthalide: 5
- Anhydrides: 241
  - Phthalic Anhydrides: 4
    - 6-hydroxy-7-methoxyphthalide: 5

Experts

1.	Corson, N: 1 article (07/2014)
2.	Preziosi, M: 1 article (07/2014)
3.	Rothberg, P G: 1 article (07/2014)
4.	Tiwary, S: 1 article (07/2014)
5.	Xu, L: 1 article (07/2014)
6.	Zeitouni, N: 1 article (07/2014)
7.	Einhorn, Lawrence: 1 article (08/2009)
8.	Tenner, Laura: 1 article (08/2009)

Related Diseases

1.	Neoplasms (Cancer) 01/15/1976 - "MA-1 and MA-2 significantly inhibited the spreading of monocytes from patients with melanoma, while monocytes from patients with other malignancies were not affected. " 09/01/1986 - "We suppose that Ma-2 antibodies to tumor specific antigens which have common antigen determinants both for Raji and RPMI-6410t cells. "
2.	Melanoma (Melanoma, Malignant) 07/07/2014 - "Here we report that ERBB3, a member of the epidermal growth factor receptor family, is required for the formation of lung metastasis from both the BI-sensitive melanoma cell line, MA-2, and the BI-resistant melanoma cell line, 451Lu-R. " 01/15/1976 - "MA-1 and MA-2 significantly inhibited the spreading of monocytes from patients with melanoma, while monocytes from patients with other malignancies were not affected. "
3.	Testicular Neoplasms (Testicular Cancer) 08/10/2009 - "Ma-2 paraneoplastic encephalitis in the presence of bilateral testicular cancer: diagnostic and therapeutic approach."
4.	Starvation 10/01/1981 - "In addition, the survival of starving cells (no growth substrate available) of spirochete MA-2 was prolonged significantly when l-valine, l-isoleucine, and l-leucine were present in starvation media. "
5.	Neoplasm Metastasis (Metastasis) 07/07/2014 - "Here we report that ERBB3, a member of the epidermal growth factor receptor family, is required for the formation of lung metastasis from both the BI-sensitive melanoma cell line, MA-2, and the BI-resistant melanoma cell line, 451Lu-R. "

Related Drugs and Biologics

1.	ErbB Receptors (EGF Receptor)
2.	Valine (L-Valine)
3.	Leucine (L-Leucine)
4.	Isoleucine (L-Isoleucine)
5.	Antigens
6.	Antibodies
7.	7-hydroxy-6-methoxyphthalide (MA-1)