cardiac glycoside receptors

Also Known As:

cardiac glycoside receptor; cardiac glycoside-binding protein (CGBG); digoxin receptor; ouabain receptor; ouabain receptors; receptor, cardiac glycosides; receptor, ouabain

Networked: 13 relevant articles (0 outcomes, 6 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Hydrolases: 2166
    - Acid Anhydride Hydrolases
      - Adenosine Triphosphatases: 8623
        P-type ATPases: 226
        Sodium-Potassium-Exchanging ATPase: 656
        cardiac glycoside receptors: 13
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Carrier Proteins: 12999
    - Membrane Transport Proteins: 589
      - P-type ATPases: 226
        Sodium-Potassium-Exchanging ATPase: 656
        cardiac glycoside receptors: 13
      - Ion Pumps: 61
        Antiporters: 369
        Sodium-Potassium-Exchanging ATPase: 656
        cardiac glycoside receptors: 13
        Cation Transport Proteins: 22
        Sodium-Potassium-Exchanging ATPase: 656
        cardiac glycoside receptors: 13
  - Membrane Proteins: 10078
    - Membrane Transport Proteins: 589
      - P-type ATPases: 226
        Sodium-Potassium-Exchanging ATPase: 656
        cardiac glycoside receptors: 13
      - Ion Pumps: 61
        Antiporters: 369
        Sodium-Potassium-Exchanging ATPase: 656
        cardiac glycoside receptors: 13
        Cation Transport Proteins: 22
        Sodium-Potassium-Exchanging ATPase: 656
        cardiac glycoside receptors: 13

Experts

1.	Blaustein, Mordecai P: 1 article (11/2017)

Related Diseases

1.	Type 2 Diabetes Mellitus (MODY) 01/01/1998 - "The aim of this study was to determine the ouabain receptor density, Na+,K(+)-ATPase function and contractile properties of cardiac muscle in insulin-dependent and non-insulin-dependent rat diabetes mellitus (IDDM and NIDDM, respectively) and the reversibility of the diabetes-induced changes by insulin or thyroxin substitution. " 11/01/1996 - "The aim of this study was to determine the ouabain receptor density, sodium content and contractile properties of skeletal muscles in rats with insulin-dependent (IDDM) and non-insulin-dependent (NIDDM) diabetes mellitus induced by streptozotocin treatment. "
2.	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 01/01/1998 - "The aim of this study was to determine the ouabain receptor density, Na+,K(+)-ATPase function and contractile properties of cardiac muscle in insulin-dependent and non-insulin-dependent rat diabetes mellitus (IDDM and NIDDM, respectively) and the reversibility of the diabetes-induced changes by insulin or thyroxin substitution. " 11/01/1996 - "The aim of this study was to determine the ouabain receptor density, sodium content and contractile properties of skeletal muscles in rats with insulin-dependent (IDDM) and non-insulin-dependent (NIDDM) diabetes mellitus induced by streptozotocin treatment. "
3.	Diabetes Mellitus 01/01/1998 - "The aim of this study was to determine the ouabain receptor density, Na+,K(+)-ATPase function and contractile properties of cardiac muscle in insulin-dependent and non-insulin-dependent rat diabetes mellitus (IDDM and NIDDM, respectively) and the reversibility of the diabetes-induced changes by insulin or thyroxin substitution. " 11/01/1996 - "The aim of this study was to determine the ouabain receptor density, sodium content and contractile properties of skeletal muscles in rats with insulin-dependent (IDDM) and non-insulin-dependent (NIDDM) diabetes mellitus induced by streptozotocin treatment. "
4.	Heart Failure 01/01/1997 - "We conclude that, unlike beta-adrenoceptors, cardiac glycoside receptors in the myocardium are not down regulated in the presence of heart failure." 04/01/1995 - "The aim was to evaluate whether digitalisation of heart failure patients affects extrarenal potassium handling during and following exercise, and to assess digoxin receptor occupancy in human skeletal muscle in vivo. " 01/01/1992 - "From these studies it can be concluded that, whereas there is a tendency for a decrease in the number of ouabain receptors in heart failure, there is no significant alteration in the expression of Na,K-ATPase message or protein caused by chronic heart failure." 08/01/1979 - "Changes in cardiac glycoside receptor sites, 86rubidium uptake and intracellular sodium concentrations in the erythrocytes of patients receiving digoxin during the early phases of treatment of cardiac failure in regular rhythm and of atrial fibrillation."
5.	Septic Shock (Toxic Shock Syndrome) 01/01/1990 - "Current progress in the studies of myocardial membrane alterations during endotoxin shock indicates that endotoxin administration impairs (Na(+) + K(+)-ATPase enzyme system by disrupting the coordination of the ouabain receptor subunit and the catalytic subunit of the enzyme system, and that the disruption is due to an alteration in the lipid microenvironment and a decrease in the phosphorylated intermediate of the enzyme cycle. "

Related Drugs and Biologics

1.	Adenosine Triphosphatases (ATPase)
2.	Insulin (Novolin)
3.	Sodium
4.	Enzymes
5.	Thyroxine (Levothyroxine)
6.	Streptozocin (Streptozotocin)
7.	Proteins (Proteins, Gene)
8.	Lipids
9.	Endotoxins
10.	Adrenergic Receptors (Adrenergic Receptor)