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humoral endorphin
endogenous opiate present in brain, blood & csf; distinguishable from both enkephalin & beta-endorphin
Also Known As:
endorphin, humoral; H-endorphin
Networked:
9
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Amino Acids, Peptides, and Proteins: 1
Proteins: 484843
Nerve Tissue Proteins: 2
Neuropeptides: 6772
Opioid Peptides: 1339
Endorphins: 977
humoral endorphin: 9
Peptides: 82426
Neuropeptides: 6772
Opioid Peptides: 1339
Endorphins: 977
humoral endorphin: 9
Related Diseases
1.
Neuroblastoma
07/01/1986 - "
Preparation of [125I-Tyr27,Leu5]beta h-endorphin and its use for crosslinking of opioid binding sites in human striatum and NG108-15 neuroblastoma-glioma cells.
"
12/01/1984 - "
Inhibition of binding of beta h-endorphin or Leu-enkephalin by beta h-endorphin analogs of various chain lengths in memmbrane preparations of the neuroblastoma x glioma NG108-15 cells has been investigated.
"
03/01/1982 - "
The potency of a series of synthetic analogs of beta-endorphin in inhibiting binding of [3H2-Tyr27]-beta h-endorphin to either rat brain membranes or neuroblastoma x glioma hybrid cells (NG108-15) has been determined and compared with the previously determined analgesic potency.
"
07/01/1986 - "
The derivative, [27-[125I]monoiodotyrosine,5-leucine]beta h-endorphin, was crosslinked to human striatal (caudate and putamen) and NG108-15 neuroblastoma-glioma cell membranes by using disuccinimidyl suberate.
"
2.
Glioma (Gliomas)
07/01/1986 - "
Preparation of [125I-Tyr27,Leu5]beta h-endorphin and its use for crosslinking of opioid binding sites in human striatum and NG108-15 neuroblastoma-glioma cells.
"
12/01/1984 - "
Inhibition of binding of beta h-endorphin or Leu-enkephalin by beta h-endorphin analogs of various chain lengths in memmbrane preparations of the neuroblastoma x glioma NG108-15 cells has been investigated.
"
03/01/1982 - "
The potency of a series of synthetic analogs of beta-endorphin in inhibiting binding of [3H2-Tyr27]-beta h-endorphin to either rat brain membranes or neuroblastoma x glioma hybrid cells (NG108-15) has been determined and compared with the previously determined analgesic potency.
"
07/01/1986 - "
The derivative, [27-[125I]monoiodotyrosine,5-leucine]beta h-endorphin, was crosslinked to human striatal (caudate and putamen) and NG108-15 neuroblastoma-glioma cell membranes by using disuccinimidyl suberate.
"
3.
Neoplasms (Cancer)
08/01/1980 - "
Chromatography of cell secretions under acid-dissociating conditions demonstrated that the human tumor cells released immunoreactive peptides with the elution profiles of alpha h (1-39) ACTH, beta h-LPH, gamma h-LPH and beta h-endorphin confirming that beta h-endorphin is secreted by human pituitary tumour cells and is not formed by enzymic cleavage from beta h-LPH in blood.
"
04/01/1980 - "
Using a sensitive radioimmunoassay for beta h-endorphin, we have demonstrated the presence of beta-endorphin immunoreactivity with size heterogeneity according to Sephadex gel chromatography and sodium dodecyl sulfate polyacrylamide gel electrophoresis in 6 ectopic ACTH/beta-LPH-producing tumors, providing further evidence for the role of a common precursor to ACTH and beta-LPH/beta-endorphin in the peptide biosynthesis in these tumors, in a manner similar to the biosynthetic events in the pituitary gland of several species.
"
4.
Wounds and Injuries (Trauma)
09/15/1989 - "
In view of S protein involvement in processes of inflammation and wound repair and beta-endorphin effects on immunocompetent cells, the demonstrated S protein-beta H-endorphin interaction appears to be of considerable functional significance.
"
5.
Tremor (Tremors)
01/17/1983 - "
Intracerebroventricular administration of leu5 - and met5 - beta h - endorphin produces sequential behavioral changes characterized by restlessness, eye fixation, head tremor, and exaggerated orienting reaction to external auditory stimuli, accompanied by EEG alterations.
"
Related Drugs and Biologics
1.
beta-Endorphin (Endorphin, beta)
2.
Adrenocorticotropic Hormone (ACTH)
3.
Sodium Dodecyl Sulfate (Sodium Lauryl Sulfate)
4.
Proteins (Proteins, Gene)
5.
Peptides (Polypeptides)
6.
Naloxone (Narcan)
7.
beta-Lipotropin (Lipotropin)
8.
Leucine (L-Leucine)
9.
Monoiodotyrosine
10.
Enkephalins