morphiceptin
synthetic tetrapeptide with morphinelike activities, highly specific for morphine receptors, but not for enkephalin receptors; is the amide of a fragment of the milk protein beta casein; deproceptin is the D-Pro(4)-isomer; see also related heptapeptide beta-casomorphin; RN given refers to parent cpd(L-Tyr-L-Pro-L-Phe-L-Pro)-isomer
Also Known As:
NH(4)-Tyr-Pro-Phe-Pro-CONH(2); Tyr-Pro-Phe-D-Pro-NH2; Tyr-Pro-Phe-Pro amide; beta-casomorphine(1-4) amide; deproceptin; morphiceptin monohydrochloride, (L-Tyr-L-Pro-L-Phe-L-Pro)-isomer; morphiceptin, (L-Tyr-D-Pro-L-Phe-L-Pro)-isomer; morphiceptin, (L-Tyr-L-Pro-L-Phe-D-Pro)-isomer; tyrosyl-prolyl-phenylalanyl-D-prolinamide
Networked: 33
relevant articles (2 outcomes,
4 trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Experts
1. | Fichna, Jakub:
7 articles
(10/2020 - 12/2002)
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2. | Janecka, Anna:
5 articles
(09/2017 - 12/2002)
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3. | Zielińska, Marta:
4 articles
(10/2020 - 02/2015)
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4. | Janecka, A:
4 articles
(11/2012 - 09/2003)
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5. | Mirowski, M:
3 articles
(04/2005 - 09/2003)
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6. | Mirowski, Marek:
3 articles
(01/2005 - 12/2002)
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7. | Krajewska, Wanda M:
2 articles
(10/2020 - 02/2015)
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8. | Sałaga, Maciej:
2 articles
(10/2020 - 02/2015)
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9. | Szymaszkiewicz, Agata:
2 articles
(10/2020 - 04/2020)
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10. | Dong, Shouliang:
2 articles
(09/2017 - 01/2013)
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Related Diseases
1. | Bradycardia
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2. | Shock
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3. | Inflammation (Inflammations)
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4. | Adenocarcinoma
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5. | Neoplasms (Cancer)
04/01/2005
- " The highest accumulation in the tumor was observed for [d-1-Nal3)morphiceptin, which reached the value of 8.19 +/- 1.14% dose/g tissue." 12/01/2002
- " Finally, new developments in the control of tumour growth and cell proliferation by morphiceptin analogues are surveyed, which open future perspectives in the diagnosis and treatment of various cancers." 09/01/2003
- " A series of new morphiceptin analogues, modified at the pharmacophoric position 3, was synthesized in order to find the correlation between the lipophilicity, electronic and steric properties of the amino acid in this position and the in vitro affinity of new analogues for mu-opioid receptors on mouse brain and tumor membranes. " 10/15/2020
- " Cyclic derivative of morphiceptin Dmt-cyclo-(D-Lys-Phe-D-Pro-Asp)-NH2(P-317), a mixed agonist of MOP and KOP opioid receptors, exerts anti-inflammatory and anti-tumor activity in colitis and colitis-associated colorectal cancer in mice." 11/01/2012
- " In the present study, we examined the effect of the mu-opioid receptor selective peptide, morphiceptin, and its two synthetic analogs on mRNA and protein levels of MMP-9 and uPA in three human cancer cell lines: MCF-7, HT-29, and SH-SY5Y. "
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