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N-methylprotoporphyrin IX

inhibitor of ferrochelatase

Also Known As:

N-methylprotoporphyrin; 21H,23H-Porphine-2,18-dipropanoic acid, 7,12-diethenyl-3,8,13,17,23-pentamethyl-

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Harris, Peggy L R: 1 article (09/2007)
2.	Moreira, Paula I: 1 article (09/2007)
3.	Oliveira, Catarina R: 1 article (09/2007)
4.	Perry, George: 1 article (09/2007)
5.	Santos, Maria S: 1 article (09/2007)
6.	Smith, Mark A: 1 article (09/2007)
7.	Zhu, Xiongwei: 1 article (09/2007)
8.	Ames, Bruce N: 1 article (11/2002)
9.	Atamna, Hani: 1 article (11/2002)
10.	Killilea, Alison Nisbet: 1 article (11/2002)

Related Diseases

1.	Mitochondrial Diseases (Mitochondrial Disease) 09/01/2007 - "AD-type changes could be generated in control fibroblasts using N-methylprotoporphyrin to inhibit cytochrome oxidase assembly indicating that the the oxidative damage observed was associated with mitochondrial dysfunction. "
2.	Neuroblastoma 11/12/2002 - "Heme, a major functional form of iron in the cell, is synthesized in the mitochondria by ferrochelatase inserting ferrous iron into protoporphyrin IX. Heme deficiency was induced with N-methylprotoporphyrin IX, a selective inhibitor of ferrochelatase, in two human brain cell lines, SHSY5Y (neuroblastoma) and U373 (astrocytoma), as well as in rat primary hippocampal neurons. "
3.	Astrocytoma (Pilocytic Astrocytoma) 11/12/2002 - "Heme, a major functional form of iron in the cell, is synthesized in the mitochondria by ferrochelatase inserting ferrous iron into protoporphyrin IX. Heme deficiency was induced with N-methylprotoporphyrin IX, a selective inhibitor of ferrochelatase, in two human brain cell lines, SHSY5Y (neuroblastoma) and U373 (astrocytoma), as well as in rat primary hippocampal neurons. "

Related Drugs and Biologics

1.	Iron
2.	Heme (Haem)
3.	Ferrochelatase (Heme Synthetase)
4.	Electron Transport Complex IV (Cytochrome c Oxidase)
5.	protoporphyrin IX
6.	heme a