2,2'- anhydro- 1- (3'- O- acetyl- beta- arabinofuranosyl)- 5- iodocytosine

RN given refers to mono-HCl, (2R-(2alpha,3beta,3abeta,9abeta))-isomer

Also Known As:

2,2'-anhydro-1-(3'-O-acetyl-beta-D-arabinofuranosyl)-5-iodocytosine hydrochloride; 2,2'-anhydro-1-(3'-O-acetyl-beta-arabinofuranosyl)-5-iodocytosine hydrochloride; anhydro-araIC 3'-acetate; 3H-Furo(2',3'-4,5)oxazolo(3,2-a)pyrimidine-2-methanol, 3-(acetyloxy)-2,3,3a,9a-tetrahydro-6-imino-7-iodo-, monohydrochloride, (2R-(2alpha,3beta,3abeta,9abeta))-

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Related Diseases

1.	Leukemia L1210 01/01/1981 - "Both anhydro-araIC 3'-acetate and anhydro-araIC were potent inhibitors of the activity of DNA polymerase alpha from the L1210 leukemia at the nucleoside level, while anhydro-araC 3'-acetate and anhydroaraC were non-inhibitory; none of the agents caused inactivation of DNA polymerase beta. "
2.	Leukemia 01/01/1981 - "The presence of the 5-iodo substituent and/or the 3'-O-acetyl group on 2,2'-anhydro1-(beta-D-arabinofuranosyl)cytosine (anhydro-araC) did not alter the capacity of these agents to exert cytotoxic and antineoplastic activity against L1210, P388, L5178Y and human leukemia cells and against human colon and rectal carcinomas, as well as antiviral activity against herpes simplex virus Type 1. All of the compounds caused inhibition of [3H]thymidine incorporation into the DNA of L1210 cells in culture, with anhydro-araIC 3'-acetate being significantly less inhibitory than the other derivatives. "
3.	Carcinoma (Carcinomatosis) 01/01/1981 - "The presence of the 5-iodo substituent and/or the 3'-O-acetyl group on 2,2'-anhydro1-(beta-D-arabinofuranosyl)cytosine (anhydro-araC) did not alter the capacity of these agents to exert cytotoxic and antineoplastic activity against L1210, P388, L5178Y and human leukemia cells and against human colon and rectal carcinomas, as well as antiviral activity against herpes simplex virus Type 1. All of the compounds caused inhibition of [3H]thymidine incorporation into the DNA of L1210 cells in culture, with anhydro-araIC 3'-acetate being significantly less inhibitory than the other derivatives. "

Related Drugs and Biologics

1.	DNA Polymerase beta (DNA Polymerase IV)
2.	Thymidine
3.	Nucleosides
4.	DNA Polymerase I (Klenow Fragment)
5.	DNA (Deoxyribonucleic Acid)
6.	Antiviral Agents (Antivirals)
7.	Antineoplastic Agents (Antineoplastics)